Bedside test may end guesswork in nerve pain treatment
NCT ID NCT06614322
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study aims to see if a quick bedside sensory test can predict which painkiller—pregabalin, duloxetine, or a placebo—works best for people with nerve pain in their feet. About 190 adults with diabetic, chemotherapy-related, or idiopathic nerve pain will try each treatment for 4 weeks. The goal is to personalize pain relief and speed up drug development.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pregabalin and duloxetine
- What this could lead to
- If successful, this could help doctors quickly match nerve pain patients to the most effective drug, reducing trial-and-error.
- What could go wrong
- This is a mid-stage study with only 190 people, so results may not apply to everyone. The sensory test might not reliably predict responses.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY (CIPN) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Beth Israel Deaconess Medical Center for Autonomic and Peripheral Nerve Disorders
RECRUITINGBoston, Massachusetts, 02215, United States
-
Ichan School of Medicine at Mount Sinai
NOT_YET_RECRUITINGNew York, New York, 10029, United States
-
University of Pittsburgh
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15206, United States
-
University of Rochester
RECRUITINGRochester, New York, 14618, United States
-
University of Utah
NOT_YET_RECRUITINGSalt Lake City, Utah, 84132, United States
-
University of Vermont
RECRUITINGBurlington, Vermont, 05401, United States
-
VCU Medical Center
NOT_YET_RECRUITINGRichmond, Virginia, 23298, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A ZAP BEHIND THE KNEE MAY QUIET DIABETIC NERVE PAIN
- Acupuncture vs. sham needles: a test for chemo nerve damage
- Video analysis could personalize rehab for chemo nerve damage
- Brain training and nerve stretching could ease chemo nerve damage
- Acupuncture and exercise join forces against chemotherapy nerve pain
- New drug candidate AH-008 takes first step toward easing chemotherapy nerve pain