Cure My Disease

Don't miss your cure!

 Log in / Sign up

A ZAP BEHIND THE KNEE MAY QUIET DIABETIC NERVE PAIN

NCT ID NCT07725419

Symptom relief Sponsor: Algiamed Technologies USA, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This trial tests whether a non-invasive device that delivers pulsed radiofrequency energy behind the knee can reduce pain and improve function in people with diabetic neuropathy whose pain persists despite medication. About 92 participants will receive either the active device or a sham version once a week for three weeks. Researchers will track pain scores and symptoms over six months to see if the treatment offers meaningful relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a non-invasive pulsed radiofrequency device applied behind the knee
What this could lead to
If it works, this could offer a drug-free option for people with diabetic nerve pain who get little relief from current medications.
What could go wrong
This is a small, early-stage trial with only 92 participants. The placebo effect is strong in pain studies, and the device may not prove better than sham treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

92 people

The number who actually took part.

Started

Dec 2016

Finished

Aug 2019

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of pedal Diabetic Peripheral Neuropathy. * A score of 4 or greater than 4/10 on the DN4 Test. * Naive to (no previous experience with) the electrical pulsed radio frequency current treatment. Exclusion Criteria: * Current pregnancy. * Presence of a pacemaker. * Presence of a peripheral or spinal cord stimulator. * Presence of metal implants in the knee and/or hip.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Diabetic peripheral neuropathic pain are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Diabetic Foot diabetic neuropathy neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetic peripheral neuropathic pain Diabetic peripheral neuropathic pain (DPN) Diabetic peripheral neuropathy

Contacts and locations

Locations

  • CDE / Clinical Sites - Pretoria

    Pretoria, Gauteng, South Africa

  • Centre for Diabetes and Endocrinology (CDE), Houghton

    Johannesburg, Gauteng, South Africa

  • Clinical Sites - Krugersdorp

    Krugersdorp, Gauteng, South Africa

  • Clinical Sites - West Johannesburg

    Johannesburg, Gauteng, South Africa

  • Diabetic Clinic at the Charlotte Maxeke Hospital

    Johannesburg, Gauteng, South Africa

More trials for these conditions

Other studies related to the condition(s) this trial covers.