DIABETIC PERIPHERAL NEUROPATHY

This study tests a sensory neuroprosthesis—implanted electrodes that send small electrical currents to remaining nerves—to restore sensation of a missing lower limb in people with diabetic peripheral neuropathy and amputation. The 15 participants will also have the option of musc…

This study tests whether injecting stem cells from umbilical cords into the legs can help people with moderate to severe diabetic nerve damage. 140 adults will get either stem cell shots plus standard care, or standard care alone, and be followed for 24 weeks. The goal is to see …

This study tests a portable DNA device called MinION that can identify bacteria and fungi in foot wounds of people with diabetes in under 4 hours. Standard lab cultures take longer and may miss some germs. The goal is to see if this faster method gives a more complete picture of …

This study tests whether a single ultrasound-guided injection of medicine around compressed leg nerves can relieve numbness, pain, and weakness in people with diabetes. 266 participants will be randomly assigned to get the real injection or a sham (fake) injection, and neither th…

This study tests whether a spinal cord stimulator can reduce pain and improve nerve function in people with diabetic peripheral neuropathy. Sixty adults with pain that hasn't responded to standard treatments will be randomly assigned to receive the implant or standard care. Resea…

This study tests whether shortwave therapy can relieve symptoms of diabetic peripheral neuropathy, a common complication causing pain and numbness. About 202 adults with diabetes will receive either real shortwave treatment or a sham device for 20 minutes daily over five days. Re…

This study tests two types of foot and ankle exercises to see which one better helps balance, walking, and fall risk in people with diabetic peripheral neuropathy (nerve damage in the feet). Researchers will compare exercises for the small muscles in the foot with 3D ankle-foot e…

This early-stage trial tests whether a cream made from a modified form of capsaicin (the stuff that makes chili peppers hot) can reduce foot pain in people with diabetic neuropathy. About 80 participants will apply the cream or a placebo to their feet twice a day for two weeks an…

This study tests whether special balance exercises or sensory retraining better improve walking and stability in people with diabetic nerve damage. 80 adults aged 40-75 with diabetes and nerve problems will be randomly assigned to one of two training programs. Both groups also re…

This study tests whether combining a hands-on nerve treatment (intraneural facilitation) with a balance exercise program can reduce pain, improve balance, and enhance quality of life in people with diabetic peripheral neuropathy. About 65 adults aged 50-75 with type 2 diabetes an…

This study will give 100 adults with diabetes a thermal camera that attaches to their smartphone to take daily pictures of their feet. The goal is to collect temperature data and see if hot spots can predict where foot ulcers might form. Participants will use the device at home f…

This study tests whether real-time visual and audio cues can help people with diabetic peripheral neuropathy walk better. Researchers will measure foot pressure and push-off force as 25 participants walk on a treadmill. The goal is to understand how biofeedback changes walking pa…

This study looks at whether environmental factors like heavy metals from gold mining, past viral infections, or traditional plant remedies are linked to peripheral neuropathy (nerve damage) in French Guiana. Researchers will compare 78 people with and without nerve damage to see …

This study is translating and testing an Arabic version of a survey that measures quality of life in people with type 2 diabetes who have nerve damage or foot ulcers. Researchers will enroll 290 Arabic-speaking adults to ensure the translated survey is accurate, reliable, and cul…