Could a chili pepper cream soothe diabetic foot pain?

NCT ID NCT07260656

Recruiting now Symptom relief Sponsor: Carilion Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests whether a cream made from a modified form of capsaicin (the stuff that makes chili peppers hot) can reduce foot pain in people with diabetic neuropathy. About 80 participants will apply the cream or a placebo to their feet twice a day for two weeks and rate their pain. The goal is to see if it works with few side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: capsaicin palmitate (Capsadyn) cream
What this could lead to: If it works, this could offer a simple, topical option to reduce chronic foot pain in people with diabetic neuropathy.
What could go wrong: This is a very early, small pilot study (80 people) testing only 14 days of use. It may not show clear pain relief, and results may not apply to everyone with diabetic foot pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for DIABETIC FOOT are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Diabetic Foot diabetic neuropathy neuropathy, painful

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC FOOT DIABETIC NEUROPATHIES, PAINFUL DIABETIC PERIPHERAL NEUROPATHY

Contacts and locations

Locations

Carilion Clinic
RECRUITING

Roanoke, Virginia, 24016, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.