Could a chili pepper cream soothe diabetic foot pain?
NCT ID NCT07260656
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial tests whether a cream made from a modified form of capsaicin (the stuff that makes chili peppers hot) can reduce foot pain in people with diabetic neuropathy. About 80 participants will apply the cream or a placebo to their feet twice a day for two weeks and rate their pain. The goal is to see if it works with few side effects.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Carilion Clinic
RECRUITINGRoanoke, Virginia, 24016, United States
Contact Phone: •••-•••-••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
capsaicin palmitate (Capsadyn) cream
What this could lead to
If it works, this could offer a simple, topical option to reduce chronic foot pain in people with diabetic neuropathy.
What could go wrong
This is a very early, small pilot study (80 people) testing only 14 days of use. It may not show clear pain relief, and results may not apply to everyone with diabetic foot pain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.