A new pill takes aim at diabetic nerve pain — will it work?

NCT ID NCT06074562

Completed Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This phase 2 trial tests whether mazisotine, an oral drug, can reduce the persistent nerve pain that often complicates diabetes. About 400 adults with diabetic peripheral neuropathic pain will receive either mazisotine or a placebo for roughly 24 weeks. Researchers will measure changes in average pain intensity to see if the drug offers meaningful relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental drug called mazisotine (LY3556050)
What this could lead to: If it works, mazisotine could offer a new oral option for the burning, stabbing nerve pain that many people with diabetes experience.
What could go wrong: This is a mid-stage trial, so the drug may not prove more effective than placebo. Side effects are possible, and the results may not apply to everyone with diabetic nerve pain.

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Conditions

The condition(s) this trial relates to.

diabetic neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETIC PERIPHERAL NEUROPATHY

Contacts and locations

Locations

Agentura Science Pro

Olomouc, 779 00, Czechia
Alliance for Multispecialty Research, LLC

Wichita, Kansas, 67205, United States
Alliance for Multispecialty Research, LLC

Lexington, Kentucky, 40509, United States
Alliance for Multispecialty Research, LLC

Kansas City, Missouri, 64114, United States
CMR of Greater New Haven, LLC

Hamden, Connecticut, 06517, United States
Care Access - Lake Charles

Lake Charles, Louisiana, 70601, United States
Centrum Badań Klinicznych Piotr Napora lekarze sp.p.

Wroclaw, Lower Silesian Voivodeship, 51-162, Poland
Centrum Medyczne Pratia Katowice

Katowice, Silesian Voivodeship, 40-081, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

Lodz, Łódź Voivodeship, 90-338, Poland
Clinvest Research LLC

Springfield, Missouri, 65807, United States
Consano Clinical Research, LLC

Shavano Park, Texas, 78231, United States
DiaVize s.r.o.

Prague, Praha, Hlavní Mešto, 140 00, Czechia
Diabet2 s.r.o., diabetologicka a interni ambulance

Prague, Praha 1, 11000, Czechia
EDUMED - Broumov

Broumov, Hradec Králové Region, 550 01, Czechia
Eulji University Hospital

Daejeon, Taejǒn-Kwangyǒkshi, 01830, South Korea
FLEDIP - Na dlouhem lanu

Prague, Praha, Hlavní Mešto, 160 00, Czechia
FutureSearch Trials of Neurology

Austin, Texas, 78731, United States
Headlands Research - Scottsdale

Scottsdale, Arizona, 85260, United States
Heishinkai Medical Group ToCROM Clinic

Shinjuku-ku, Tokyo, 160-0008, Japan
Hope Clinical Research, Inc.

Canoga Park, California, 91303, United States
Japanese Red Cross Asahikawa Hospital

Asahikawa, Hokkaido, 070-8530, Japan
Juno Research

Houston, Texas, 77040, United States
Kikuchi Naika Clinic

Maebashi, Gunma, 370-3573, Japan
Konkuk University Medical Center

Seoul, Seoul-teukbyeolsi [Seoul], 05030, South Korea
Kunisaki Makoto Clinic

Fukuoka, 819-0168, Japan
Kure Medical Center

Kure, Hiroshima, 737-0023, Japan
Las Vegas Medical Research

Las Vegas, Nevada, 89128, United States
Lucas Research - Hickory

Hickory, North Carolina, 28601, United States
Lucas Research, Inc

Morehead City, North Carolina, 28557, United States
MICS Centrum Medyczne Torun

Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland
MICS Centrum Medyczne Warszawa

Warsaw, Masovian Voivodeship, 00-874, Poland
Matsuyama Shimin Hospital

Matsuyama, Ehime, 790-0067, Japan
MedVadis Research Corporation

Waltham, Massachusetts, 02451, United States
Medical Corporation Heishinkai OCROM Clinic

Suita-shi, Osaka, 565-0853, Japan
Medical Corporation Sato Medical clinic

Ootaku, Tokyo, 143-0015, Japan
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

Krakow, Lesser Poland Voivodeship, 31-261, Poland
Minamiosaka Hospital

Osaka, 559-0012, Japan
NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki

Ruda Śląska, Silesian Voivodeship, 41-709, Poland
Neurologická Ambulance - Forbeli

Prague, Praha 6, 160 00, Czechia
New Horizon Research Center

Miami, Florida, 33165, United States
New Phase Research and Development

Knoxville, Tennessee, 37909, United States
North Suffolk Neurology

Port Jefferson Station, New York, 11776, United States
Northern California Research - Sacramento

Sacramento, California, 95821, United States
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Northwestern University

Chicago, Illinois, 60611, United States
Nowon Eulji Medical Center, Eulji University

Seoul, Seoul-teukbyeolsi [Seoul], 01830, South Korea
Nzoz Neuro-Kard Ilkowski i Partnerzy SPL

Poznan, Greater Poland Voivodeship, 61-853, Poland
Orange Grove Family Practice

Tucson, Arizona, 85741, United States
Plumeria DM Clinic

Shizuoka, 422-8006, Japan
Preferred Research Partners

Little Rock, Arkansas, 72211, United States
Pro Familia Altera

Katowice, Silesian Voivodeship, 40-648, Poland
Rainier Clinical Research Center

Renton, Washington, 98057, United States
SKY Integrative Medical Center/SKYCRNG

Ridgeland, Mississippi, 39157, United States
Samodzielny Publiczny Zespol Opieki Zdrowotnej w Wyszkow

Wyszków, Masovian Voivodeship, 07-200, Poland
Samsung Medical Center

Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea
Sejong General Hospital

Sosa-gu, Kyǒnggi-do, 14754, South Korea
StudyMetrix Research

City of Saint Peters, Missouri, 63303, United States
Suburban Research Associates

West Chester, Pennsylvania, 19380, United States
Sugiura Internal Medicine Clinic

Sokashi, Saitama, 340-0015, Japan
Suncoast Research Group

Miami, Florida, 33135, United States
Suruga Clinic

Shizuoka, Shizuoka, 424-0855, Japan
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

Chandler, Arizona, 85225, United States
Tristar Clinical Investigations

Philadelphia, Pennsylvania, 19114, United States
UniMed Center

East Brunswick, New Jersey, 08816, United States
Valley Clinical Trials, Inc.

Northridge, California, 91325, United States
Velocity Clinical Research, Medford

Medford, Oregon, 97504, United States
Velocity Clinical Research, Salt Lake City

West Jordan, Utah, 84088, United States
Vestra Clinics

European Union, Rychnov Nad Kněžnou, 516 01, Czechia
Yokohama Minoru Clinic

Yokohama, Kanagawa, 232-0064, Japan
Zdrowie Osteo-Medic

Biaystok, Podlaskie Voivodeship, 15-351, Poland

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