DIABETIC FOOT

This study tests a new procedure that reroutes blood flow in the foot to save the leg in people with severe, untreatable limb-threatening ischemia. About 50 adults who have no other options and are at risk of amputation will receive the treatment. The goal is to see if the proced…

This study tests whether adding a placental-based skin substitute to standard wound care helps close hard-to-heal diabetic foot ulcers faster than standard care alone. About 272 adults with diabetes and a foot ulcer present for 4 to 52 weeks will receive either the skin substitut…

This study tests whether a special graft made from placental tissue, along with standard wound care, can help close diabetic foot ulcers that won't heal on their own. About 60 adults with diabetes and a nonhealing foot ulcer will receive either the graft plus standard care or sta…

This study tests a smart mat that checks foot temperature at home to help prevent diabetic foot ulcers in 800 Veterans with diabetes who have had a foot ulcer or amputation. The mat sends data to a monitoring team that alerts VA providers if a problem is detected. The goal is to …

This study tests whether special smart insoles, worn inside shoes, can help prevent foot ulcers in people with diabetes who have nerve damage and a history of foot sores. The insoles measure pressure and temperature on the feet and give feedback to the user. Researchers will comp…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study tests whether a cream made with a modified form of capsaicin (the stuff that makes chili peppers hot) can reduce foot pain in people with diabetic nerve damage. About 80 adults will apply the cream or a placebo to their painful feet twice a day for two weeks and rate t…

This study looks at people with diabetic foot ulcers to see if a history of biofilm infection leads to weaker skin barrier function after the wound closes. Researchers will measure water loss through the healed skin to predict if the wound is likely to return. The goal is to unde…

This observational study aims to understand how immune cells affect healing in diabetic patients with chronic foot ulcers. Researchers will compare blood and tissue samples from 40 patients whose ulcers are healing versus those that are not. The goal is to identify specific immun…

This study aims to find biological markers that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples from 5,000 adults with diabetes and an open foot ulcer. The goal is to improve personalized treatment decisions and make future wound-heali…