DIABETIC FOOT

This study tests whether a special scaffold made from pig liver tissue, called Miro3D, can help heal chronic diabetic foot ulcers when added to standard wound care. About 180 adults with non-healing ulcers will be randomly assigned to receive either Miro3D plus standard care or s…

This study tests a procedure that connects an artery to a vein in the foot to bring blood to tissues when standard treatments have failed. It includes 50 patients with severe leg artery disease and active wounds. The goal is to see if the procedure is safe and can prevent major a…

This study tests whether adding a placental-based skin substitute to standard wound care helps close hard-to-heal diabetic foot ulcers faster than standard care alone. About 272 adults with diabetes and a foot ulcer present for 4 to 52 weeks will receive either the skin substitut…

This study tests whether a special graft made from donated placental tissue, called XWRAP, can help heal diabetic foot ulcers that won't close with standard care alone. About 60 adults with type 1 or type 2 diabetes will receive either the graft plus standard wound care or standa…

This study tests a smart mat that checks foot temperature at home to catch early signs of damage in high-risk diabetes patients. 800 Veterans with a history of foot ulcers or amputation will use the mat for up to 24 months. The goal is to see if this technology can prevent new ul…

This study tests if special sensor-equipped insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. About 400 high-risk participants will use the insoles alongside standard care or just standard care alone. The goal is to see if the insoles…

This early-stage trial tests whether a cream made from a modified form of capsaicin (the stuff that makes chili peppers hot) can reduce foot pain in people with diabetic neuropathy. About 80 participants will apply the cream or a placebo to their feet twice a day for two weeks an…

This study looks at whether repairing blocked leg blood vessels within 48 hours helps heal foot ulcers in people with type 2 diabetes faster than waiting for a scheduled procedure. About 200 adults with diabetic foot sores will be randomly assigned to early or standard treatment.…

This study looks at how biofilm infections in diabetic foot ulcers affect skin healing and whether poor skin barrier function leads to the wound coming back. Researchers will measure water loss through healed skin to check barrier strength. The goal is to understand the link betw…

This study aims to find biological markers (biomarkers) that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples like blood and wound fluid from 5,000 adults with diabetes and open foot ulcers. The goal is to develop a tool that helps doct…

This observational study will compare blood and tissue samples from 40 diabetic patients with foot ulcers. Researchers want to understand how immune cells differ between people whose ulcers heal and those whose ulcers do not. The goal is to identify specific immune cell patterns …