DIABETIC FOOT

This study looks at whether opening blocked leg arteries within 48 hours (early angioplasty) helps heal foot ulcers faster in people with type 2 diabetes compared to waiting for a scheduled procedure. Researchers will track wound healing with a 3D camera and study how the wound's…

This study tests if a smart mat that checks foot temperature at home can help prevent foot ulcers in 800 Veterans with diabetes who have had a foot ulcer or amputation. The mat sends data to a remote team that alerts VA providers if problems are found. The goal is to reduce ulcer…

This study tests a new procedure that reroutes blood flow in the foot to save the leg from amputation. It is for people with severe leg artery disease who have no other treatment options. The study will check if the procedure is safe and works well in 50 participants.

This study tests whether a special graft made from donated placental tissue can help heal foot ulcers in people with diabetes that have not healed with standard care. About 60 adults with type 1 or 2 diabetes and a nonhealing foot ulcer will receive either the graft plus standard…

This study tests whether a special skin graft made from donated placental tissue, plus standard wound care, can help close hard-to-heal diabetic foot ulcers faster than standard care alone. About 272 adults with diabetes and a foot ulcer that hasn't healed after 4 to 52 weeks wil…

This study tests a cream made with a special form of capsaicin (the stuff that makes chili peppers hot) to see if it can reduce foot pain in people with diabetic nerve damage. About 80 adults will apply the cream twice a day for two weeks and rate their pain. The goal is to find …

This study looks at diabetic foot ulcers to see if a history of biofilm infection leads to poor skin barrier healing and higher chances of the wound coming back. Researchers will measure water loss through the healed skin as a sign of barrier weakness. The goal is to understand t…

This study will enroll 5,000 adults with diabetes and open foot ulcers to test whether certain biomarkers can predict which wounds will heal. Researchers will collect blood, wound fluid, and tissue samples to measure healing, infections, and amputations over 52 weeks. The goal is…

This study looks at how immune cells differ in diabetic patients whose foot ulcers heal versus those that don't. Researchers will compare blood and tissue samples from 40 participants. The goal is to find specific immune cell patterns that may explain why some ulcers become chron…