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Could a simple patch replace painful needle tests for ICU muscle weakness?

NCT ID NCT07699562

Knowledge-focused Sponsor: Endeavor Health Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study is testing whether a non-invasive nerve monitoring device called TetraGraph can accurately detect early signs of ICU-acquired weakness. Researchers will compare readings from the device with standard needle-based electromyography (EMG) tests in healthy volunteers and ICU patients, both on and off ventilators. The goal is to see if the non-invasive method can reliably track muscle response signals in the hand and leg over about 10 days.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
TetraGraph (non-invasive nerve monitoring device)
What this could lead to
If the TetraGraph proves accurate, it could offer a simpler, less painful way to detect muscle weakness early in ICU patients, potentially improving outcomes.
What could go wrong
This is a small, early-stage study with only 24 participants. The device may not match the accuracy of standard invasive tests, and results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Cohort 1: Healthy volunteers Inclusion criteria: * Subjects must be \> 18 years old and \< 90 years old. * Subjects must consent to participate. Cohort 2: Non-intubated critically ill patients Inclusion criteria: * Subjects may be male or female. * Subjects must be \> 18 years old and \< 90 years old. * Subjects must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves). Cohort 3: Intubated critically ill patients Inclusion criteria: * Subjects may be male or female. * Subjects must be \> 18 years old and \< 90 years old. * Subjects must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves). * For the Subjects in the ICU that are intubated, they must be planned to be intubated for at least 24 hours. * Subjects must be intubated for no longer than ≥ 72 hours before enrollment. Exclusion Criteria: * Cohort 1: Healthy volunteers Exclusion criteria: * Subjects with previous paralysis or neuromuscular disease. * Subjects with spinal cord or brain injuries that impact motor function. * Subjects with an allergy to clinical adhesive or hydrogel. Cohort 2: Non-intubated critically ill patients Exclusion criteria: * Subjects with previous paralysis or neuromuscular diseases. * Subjects with previous peripheral nerve injuries to the tested limbs. * Subjects with spinal cord or brain injuries (including stroke) that impact motor function. * Subjects without a POA or next of kin for those patients that are unable to consent themselves. * Subjects with an allergy to clinical adhesive or hydrogel. Cohort 3: Intubated critically ill patients Exclusion criteria: * Subjects with previous paralysis or neuromuscular disease * Subjects with previous peripheral nerve injuries to the tested limbs. * Subjects with spinal cord or brain injuries that impact motor function. * Subjects without a POA or next of kin for those patients that are in the intubated arm. * Subjects with intubations expected to last less than 24 hours. * Subjects who have already been intubated for \> 72 hours. * Subjects with an allergy to clinical adhesive or hydrogel.

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Conditions

The condition(s) this trial relates to.

critical illness polyneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Icu acquired weakness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Endeavor Health

    RECRUITING

    Evanston, Illinois, 60201, United States

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