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Could a softer sedation and early exercise keep ICU patients stronger?

NCT ID NCT07677488

Completed Disease control Sponsor: The First Affiliated Hospital of Soochow University Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests whether a combination of a gentle sedation strategy (called eCASH) and early, personalized exercise can prevent muscle weakness that often develops in ICU patients who need a breathing machine. The trial will include 70 adults on ventilators, with half receiving the new approach and half receiving standard care. Researchers will measure muscle strength and other outcomes like breathing function and medication use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
eCASH-based analgesia and sedation strategy combined with early goal-directed mobilization
What this could lead to
If effective, this approach could become a standard care method to help ICU patients on ventilators recover strength faster and reduce long-term disability.
What could go wrong
This is a small, single-center trial with 70 participants, so results may not apply broadly. The intervention is complex and may be difficult to implement consistently across different ICUs.

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Conditions

The condition(s) this trial relates to.

agnosia Critical Illness critical illness polyneuropathy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL ILLNESS ICU ACQUIRED WEAKNESS MECHANICAL VENTILATION

Contacts and locations

Locations

  • The First Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, 215006, China

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