The First Affiliated Hospital Of Soochow University

This study is for adults with a certain type of acute myeloid leukemia (AML) who are in remission and planning a stem cell transplant. It compares a combination of two drugs, venetoclax and azacitidine, against standard high-dose chemotherapy as a 'consolidation' step before the …

This study tests whether a combination of venetoclax and azacitidine works better than standard chemotherapy to keep high-risk acute myeloid leukemia (AML) from coming back before a stem cell transplant. About 216 adults who have already achieved remission after initial treatment…

This study tests a new approach for people newly diagnosed with a specific, aggressive leukemia (Ph+ ALL). It combines a single infusion of specially engineered immune cells (CAR-T cells) with a daily targeted pill (olverembatinib). The goal is to see if this powerful one-two pun…

This early study tests a new treatment called RN1201 for people newly diagnosed with multiple myeloma, a type of blood cancer. RN1201 uses specially engineered immune cells from a healthy donor to target and kill cancer cells. Participants receive a single infusion of these cells…

This study tests a new drug, trastuzumab rezetecan, for people with HER2-positive early breast cancer whose tumors don't shrink enough after two cycles of standard therapy. About 124 participants will first receive standard treatment, and those with a poor response will switch to…

This early-stage study tests a new treatment called RN1201 for people with certain blood disorders caused by the immune system attacking the body's own cells. The treatment involves giving patients specially designed immune cells after a short course of chemotherapy to weaken the…

This study tests whether transplanting a patient's own fecal bacteria can prevent acute graft-versus-host disease (GVHD) after a stem cell transplant. GVHD is a serious condition where donor cells attack the patient's body. The trial will enroll 100 bone marrow transplant patient…

This study tests whether fecal microbiota transplantation (FMT) can safely treat gut graft-versus-host disease (GVHD), a serious complication after stem cell transplants. Researchers will track changes in stool frequency and volume in 50 participants aged 10 to 60. The goal is to…

This study tests a weekly injection called romiplostim in 60 adults with immune thrombocytopenia (ITP) whose platelet counts stayed low despite oral medications. The goal is to see if the shot can safely raise platelet levels and reduce bleeding over 24 weeks. Participants stop t…

This study tests a combination of five drugs (VABu) given before a stem cell transplant in people aged 60 and older with acute myeloid leukemia (AML). The goal is to see if this approach can help control the disease and improve survival. About 20 participants will receive the tre…

This phase 2 trial is testing a new treatment strategy for adults newly diagnosed with a type of blood cancer called B-cell acute lymphoblastic leukemia (B-ALL). The approach combines a reduced-dose chemotherapy with a full course of the immunotherapy drug blinatumomab, and may a…

This phase 2 trial is testing whether combining an immunotherapy drug (anti-PD-1) with two chemotherapy-like drugs (lenalidomide and azacitidine) can shrink tumors in people with peripheral T-cell lymphoma that has come back or not responded to prior treatment. About 31 participa…

This study looks at whether menin inhibitors can help prevent leukemia from coming back in patients who have had a stem cell transplant. About 20 adults with certain genetic types of acute leukemia will take these drugs as maintenance therapy. Researchers will track how many pati…

This study tests whether a new chemotherapy combination (TmBU) works better than the standard one (mBUCY) before a stem cell transplant in people with high-risk or hard-to-treat acute leukemia. About 48 patients aged 65 or younger will be randomly assigned to one of the two regim…

This study tests a new combination of drugs (cladribine, lisaftoclax, busulfan, and others) given before a stem cell transplant in 30 older adults (age 50+) with relapsed or refractory acute myeloid leukemia or myelodysplastic syndromes. The goal is to see if this approach can re…

This study tests whether a once-weekly injection (romiplostim) can help platelets recover faster and more safely than a daily injection (rhTPO) after a donor stem cell transplant. It includes 66 adults with MDS or severe aplastic anemia. The goal is to reduce bleeding risk and tr…

This phase 2 trial is testing a combination of targeted drugs and chemotherapy in 35 people newly diagnosed with a specific, hard-to-treat form of diffuse large B-cell lymphoma (DLBCL) that has a TP53 mutation. The goal is to see if this precision approach can improve how long pa…

This study tests whether adding umbilical cord blood to a half-matched stem cell transplant can help people with aplastic anemia, a serious condition where the bone marrow stops making enough blood cells. About 224 participants aged 14 and older will receive either the combined t…

This study tests a sequence of two immunotherapy drugs, blinatumomab and inotuzumab ozogamicin, in people with B-cell acute lymphoblastic leukemia (B-ALL). It includes newly diagnosed patients who are older or too frail for intensive chemotherapy, as well as those whose cancer ha…

This Phase 3 trial tests whether the drug gilteritinib is better than sorafenib at keeping leukemia from coming back in patients with a specific gene mutation (FLT3-ITD) after a stem cell transplant. About 594 adults and teens will take one of the two pills daily for up to 2 year…

This study tests whether adding chidamide to the standard venetoclax and azacitidine (VA) regimen can help people with acute myeloid leukemia (AML) who did not improve after one cycle of VA alone. About 32 adults aged 18 or older who are not candidates for intensive chemotherapy …

This early study tests a new treatment called U69, which uses a patient's own immune cells modified to find and attack cancer cells in T-cell leukemia or lymphoma that has come back or not responded to other treatments. About 12 to 18 people aged 15 to 75 will receive the therapy…

This study tests whether combining venetoclax with azacitidine can help people with newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL) achieve remission. About 28 participants aged 15 and older will receive the drug combination for up to two 21-day cycles. The main goal …

This study tests whether a maintenance therapy using a hypomethylating agent (HMA) can help prevent relapse and improve survival in people with favorable risk acute myeloid leukemia (AML). About 77 participants who are already in remission after initial treatment will receive HMA…

This early-stage trial is testing an oral drug called BY002 in 18 adults with relapsed or refractory acute leukemia that has specific genetic changes (KMT2A rearrangements or NPM1 mutations). The main goals are to check the drug's safety, find the best dose, and see if it can shr…

This study is testing whether a combination of three drugs—venetoclax, a hypomethylating agent (azacitidine or decitabine), and low-dose cytarabine—can effectively treat adults newly diagnosed with a specific genetic subtype of acute myeloid leukemia (CEBPA-mutated AML) who are n…

This study tests a new approach for people with untreated marginal zone lymphoma, a slow-growing blood cancer. Participants first get a short course of standard chemotherapy, then a targeted drug called orelabrutinib to keep the cancer under control. The goal is to see if this co…

This study tests a combination of three drugs (zeprumetostat, azacitidine, and mitoxantrone hydrochloride liposome) in about 26 adults with peripheral T-cell lymphoma that has come back or not responded to prior treatment. The goal is to see if this mix can shrink tumors and help…

This study is testing a combination of three drugs—venetoclax, cladribine, and low-dose cytarabine—in 36 people aged 15–70 with relapsed or refractory Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (B-ALL). The goal is to see how well the treatment shrinks o…

This phase 2 trial tests a combination of three drugs—venetoclax, cladribine, and low-dose cytarabine—in 68 adults aged 16-70 with acute myeloid leukemia that has returned or not responded to prior treatment. The goal is to see if this cocktail can shrink or eliminate leukemia ce…

This study tests a combination of two drugs, zanubrutinib and rituximab, for people with B-cell lymphoma who develop a severe immune overreaction called hemophagocytic lymphohistiocytosis (HLH). The trial will enroll 40 participants and aims to see how well the treatment controls…

This study tests a combination of two drugs, romiplostim and rituximab, in about 30 adults with primary immune thrombocytopenia (ITP) whose condition did not improve with standard oral treatments. Participants receive weekly injections of romiplostim and four weekly infusions of …

This study tests a combination of three drugs (pirtobrutinib, lisaftoclax, and rituximab) in adults with diffuse large B-cell lymphoma that has come back or not responded to at least one prior treatment. The goal is to see if this combination can shrink or eliminate tumors. About…

This study tests a combination of a PD-1 inhibitor (camrelizumab), a chemotherapy drug (azacitidine), and donor immune cells (DLI) in 43 adults with acute myeloid leukemia that has returned after a stem cell transplant. The goal is to see if this approach can help patients achiev…

This study tests a combination of three drugs (venetoclax, azacytidine, and chidamide) in people newly diagnosed with a specific type of leukemia (acute monocytic leukemia) who are not healthy enough for intensive chemotherapy. The goal is to see if this drug mix can put the canc…

This early-phase trial tests a two-step treatment for adults with B-cell acute lymphoblastic leukemia (B-ALL) who cannot have a standard donor stem cell transplant. First, patients receive the drug blinatumomab to clear any remaining cancer cells, then they undergo their own stem…

This study compares four different drug combinations for adults newly diagnosed with acute myeloid leukemia (AML) who are not healthy enough for standard intensive chemotherapy or choose not to have it. The goal is to see which combination works best to keep the cancer away longe…

This early-phase study tests a new treatment called CT0596 CAR-T cells for people with multiple myeloma or plasma cell leukemia that has come back or not responded to standard therapies. The main goals are to check safety, find the best dose, and see how well it controls the canc…

This phase 2 trial is testing a five-drug combination for a rare, aggressive type of T-cell leukemia called ETP-ALL. The study aims to see if this mix can help more patients achieve remission after their first treatment. About 27 newly diagnosed adults will receive the drugs, and…

This study tests a combination of drugs (venetoclax plus azacitidine, decitabine, or cytarabine) without traditional anthracycline chemotherapy in 40 adults newly diagnosed with a specific genetic subtype of acute myeloid leukemia (CBFβ::MYH11-positive). The goal is to see if thi…

This study is testing whether a simple blood test can accurately diagnose systemic mastocytosis, a rare disease where too many mast cells build up in the body. Currently, diagnosis requires an invasive bone marrow biopsy. The blood test looks for a specific genetic mutation (KIT-…

This study is testing new types of MRI scans to see if they can more accurately find and grade prostate cancer without using contrast dye. Researchers will compare these new scans with standard MRI results and tissue samples from surgery or biopsy. About 300 people with suspected…

This study is testing an artificial intelligence (AI) model designed to help doctors detect early gastric (stomach) cancer during endoscopy. The AI combines images from standard and enhanced endoscopy with patient data to improve accuracy and explain its reasoning. Researchers wi…

This study tests whether a one-time infusion of amimestrocel, made from donated umbilical cord cells, can prevent severe mouth and gut sores in people receiving a stem cell transplant. About 22 adults will get the infusion before their transplant, and researchers will monitor for…

This study looks at whether giving letermovir for a longer time (up to 28 weeks) can prevent cytomegalovirus (CMV) infection in Chinese adults who have a high risk of reactivation after a stem cell transplant. Participants must be at least 18, have had a stem cell transplant, and…

This study tests whether using virtual reality for mindfulness therapy can help adults with long-term low back pain feel better and move easier. About 214 people aged 20-70 will either get 8 weeks of VR mindfulness sessions plus usual care, or just usual care. The goal is to see …

This study tests whether repeated magnetic pulses to the brain (rTMS) can reduce abdominal pain and diarrhea in people with diarrhea-predominant irritable bowel syndrome (IBS-D). 46 adults will receive either real or sham rTMS for 20 minutes daily over 3 weeks. Researchers will a…

This study tests whether low-frequency magnetic stimulation to a brain area linked to pain can reduce chronic visceral pain in people with irritable bowel syndrome with diarrhea (IBS-D). 42 adults will receive either real or sham stimulation daily for two weeks. The goal is to se…

This early-stage trial is testing a new drug, IBI3002, in adults with asthma that is not fully controlled by their current inhalers. About 12 to 27 participants will receive either the drug or a placebo by injection to see if it is safe and how the body processes it. The study is…

This study tests whether warming the local anesthetic used in epidural pain relief to body temperature (37°C) can lower the chance of fever during labor. About 424 women from two hospitals will take part. Half will get the warmed solution, half will get room-temperature solution.…

This study looks at whether measuring the amount of venetoclax in the blood can help doctors give the right dose to people with newly diagnosed acute myeloid leukemia (AML). Currently, everyone gets the same dose, but drug levels vary a lot between patients. The goal is to find a…

This study tracks 200 patients who have had a stem cell transplant to understand their nutritional health. Researchers measure body composition, food intake, and blood protein levels over six months. The goal is to see if better nutrition leads to longer survival and fewer compli…

This study is looking at whether certain carbohydrates in food, called FODMAPs, are related to graft-versus-host disease (GVHD) in people who have had a bone marrow transplant. GVHD is a common complication where donor cells attack the patient's body. Researchers will track 100 t…