The First Affiliated Hospital Of Soochow University

This study tests a combination of three drugs (anti-PD-1 antibody, lenalidomide, and azacitidine) in people with peripheral T-cell lymphoma that has come back or not responded to prior treatment. The goal is to see if this combination can shrink tumors and improve survival. About…

This study is for people with aplastic anemia, a condition where the bone marrow stops making enough blood cells. Researchers are testing if adding umbilical cord blood to a half-matched stem cell transplant from a family member can help the body accept the new cells faster and w…

This study is testing an experimental treatment called U96, a type of CAR-T therapy that works inside the body, for people with relapsed or refractory B-cell leukemia or lymphoma. About 30 to 48 adults will receive the therapy and be closely monitored for side effects and how wel…

This study looks at whether menin inhibitors can help prevent leukemia from coming back in patients who have already had a stem cell transplant. About 20 people with certain genetic changes (like NPM1 or KMT2A mutations) will take these drugs as part of their regular care. Resear…

This study tests a combination of two drugs—romiplostim and rituximab—in about 30 adults with primary immune thrombocytopenia (ITP) whose condition did not improve with standard oral treatments. Participants receive weekly injections of romiplostim and four weekly infusions of ri…

This study is for people aged 16 to 70 with acute myeloid leukemia (AML) that has returned or not improved after standard treatment. Researchers are testing a combination of three drugs (venetoclax, cladribine, and low-dose cytarabine) to see if it can shrink or eliminate the can…

This study tests a combination of three drugs (pirtobrutinib, lisaftoclax, and rituximab) in adults with diffuse large B-cell lymphoma that has come back or not responded to at least one prior treatment. The goal is to see if this combo can shrink tumors or make them disappear. A…

This study tests a combination of three treatments—a PD-1 inhibitor, azacitidine, and low-dose donor lymphocyte infusion—in people whose acute myeloid leukemia has returned after a stem cell transplant. The goal is to see if this approach can help control the leukemia and improve…

This early-phase trial tests a new oral drug called BY002 in 18 adults with acute leukemia that has come back or not responded to standard treatments. The drug targets specific genetic changes (KMT2A rearrangements or NPM1 mutations) that drive the cancer. The main goals are to c…

This study tests whether a maintenance drug called HMA can help people with a favorable type of acute myeloid leukemia (AML) stay in remission longer and live longer. About 77 adults who have already achieved remission after initial treatment will receive HMA therapy. The goal is…

This study tests a treatment that uses a patient's own immune cells, modified to target and kill cancer cells, for people with a type of blood cancer (B-cell acute lymphoblastic leukemia) that has not responded to standard treatments or has come back. The goal is to see if this t…

This study tests a combination of two drugs, zanubrutinib and rituximab, along with other medications, to treat a serious immune overreaction called HLH that can happen in people with B-cell lymphoma. The goal is to control the overactive immune system and improve survival. About…

This study compares four different drug combinations for adults newly diagnosed with acute myeloid leukemia (AML) who cannot tolerate or choose not to have intensive chemotherapy. The combinations include venetoclax and azacitidine (VA) alone or with added cladribine, chidamide, …

This study is testing a new treatment approach for adults with B-cell acute lymphoblastic leukemia (B-ALL) who cannot or choose not to have a donor stem cell transplant. The treatment uses the drug blinatumomab before and after a transplant using the patient's own stem cells, aim…

This study tests a new treatment for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia. It combines a reduced dose of chemotherapy with an immunotherapy drug (blinatumomab) and, in some cases, CAR-T cell therapy. The goal is to improve survival and red…

This study tests whether the drug gilteritinib works better than sorafenib at keeping leukemia from coming back in people with a specific genetic mutation (FLT3-ITD) after a stem cell transplant. About 594 participants will be randomly assigned to take one of the two drugs for up…

This study tests a combination of three drugs (venetoclax, cladribine, and low-dose cytarabine) in 36 people aged 15-70 with relapsed or treatment-resistant Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia. The goal is to see how many patients achieve complete…

This study tests a new approach for people newly diagnosed with a fast-growing blood cancer called diffuse large B-cell lymphoma that has a specific genetic change (TP53 mutation). The treatment is matched to each person's genetic subtype to improve effectiveness. About 35 adults…

This study tests a three-drug combination (chidamide, venetoclax, and azacitidine) in adults with acute myeloid leukemia whose cancer did not respond to the first round of venetoclax and azacitidine. The goal is to see if adding chidamide can improve remission rates. About 32 par…

This study tests a new combination of drugs (cladribine, lisaftolax, and busulfan) given before a stem cell transplant in 30 older adults (50+) with relapsed or hard-to-treat acute myeloid leukemia or myelodysplastic syndromes. The goal is to make the transplant safer and more ef…

This study tests a new approach for people with a slow-growing lymphoma called marginal zone lymphoma (MZL). Participants first get a short course of standard chemo, then a targeted drug (Orelabrutinib) to keep the cancer under control. The goal is to see if this approach improve…

This study tests a two-step immunotherapy approach for people with B-cell acute lymphoblastic leukemia (B-ALL) who are older, too frail for standard chemo, or whose cancer has returned. Participants will receive two targeted drugs in sequence: blinatumomab and inotuzumab ozogamic…

This study tests a combination of three drugs (venetoclax, azacytidine, and chidamide) for people newly diagnosed with a specific type of leukemia called acute monocytic leukemia who are not healthy enough for standard intensive chemotherapy. The goal is to see if this drug combo…

This study tests whether a once-weekly injection (romiplostim) can help platelets recover faster and more safely after a donor stem cell transplant in people with myelodysplastic syndrome (MDS) or severe aplastic anemia. About 66 adults will be randomly assigned to receive either…

This study tests a combination of two drugs, venetoclax and azacitidine, in people newly diagnosed with T-cell acute lymphoblastic leukemia (T-ALL), a rare and aggressive blood cancer. The goal is to see if this treatment can help more patients achieve remission. About 28 partici…

This study tests a new drug combination called VABu given before a stem cell transplant in people aged 60 and older with acute myeloid leukemia (AML). The goal is to see if this approach can help control the disease and improve survival. About 20 participants will receive the VAB…

This study tests a new mix of three drugs—zeprumetostat, azacitidine, and mitoxantrone hydrochloride liposome—in adults whose peripheral T-cell lymphoma has come back or not responded to earlier treatments. About 26 people will receive up to 6 cycles of the combination, then up t…

This early-phase study tests a new treatment called CT0596 CAR-T cells for people with multiple myeloma or plasma cell leukemia that has come back or not responded to standard therapies. The main goals are to check safety and find the right dose. About 24 adults will take part, a…

This study tests a combination of three drugs (venetoclax, a hypomethylating agent, and low-dose cytarabine) in adults newly diagnosed with a specific genetic subtype of acute myeloid leukemia (CEBPA-mutated) who cannot tolerate strong chemotherapy. The goal is to see if this tre…

This study tests if a new chemotherapy combination (TmBU) works better than the standard one (mBUCY) before a stem cell transplant for people with high-risk or hard-to-treat acute leukemia. About 48 adults aged 65 or younger will be randomly assigned to one of the two regimens. T…

This early-stage trial tests a new treatment called U69, which uses specially engineered immune cells (CAR-T cells) to find and attack cancer cells in patients with T-cell leukemia or lymphoma that has come back or not responded to standard treatments. The study aims to check the…

This study tests a combination of five drugs (venetoclax, azacitidine, chidamide, vindesine, and dexamethasone) in adults newly diagnosed with a rare, aggressive leukemia called ETP-ALL. The goal is to see if this mix can help more patients achieve remission. About 27 people will…

This study tests a new drug combination (venetoclax plus other medicines) without traditional strong chemotherapy for adults newly diagnosed with a rare genetic subtype of acute myeloid leukemia. The goal is to see if this gentler approach can achieve complete remission and reduc…

This study looks at whether a blood test can accurately diagnose systemic mastocytosis, a rare disease where too many mast cells build up in the body. Currently, diagnosis requires an invasive bone marrow biopsy. Researchers will test blood from 50 adults for a specific genetic c…

This study is testing a new artificial intelligence (AI) model that helps doctors detect early gastric cancer during endoscopy. The AI combines different types of images and patient data to improve accuracy and explain its reasoning. About 100 adults with suspicious stomach lesio…

This study tests whether new types of MRI scans can more accurately detect and grade prostate cancer without using contrast dye. Researchers will compare these advanced scans with standard MRI and biopsy results in 300 men with suspected prostate cancer. The goal is to improve di…

This study tests whether giving patients their own healthy gut bacteria (via a fecal transplant) can prevent acute graft-versus-host disease (GVHD) after a half-matched stem cell transplant. About 100 bone marrow transplant patients will be randomly assigned to receive the fecal …

This study tests whether a single infusion of amimestrocel, a cell therapy made from human umbilical cord cells, can prevent severe mouth and gut sores in patients receiving a stem cell transplant. About 22 adults will receive the infusion 1-2 days before their transplant. Resear…

This study tests whether taking letermovir for a longer time (up to 28 weeks) can prevent cytomegalovirus (CMV) infection in 330 high-risk Chinese adults who have received a stem cell transplant. CMV is a common and serious complication in these patients because their immune syst…

This study tests whether using virtual reality (VR) for mindfulness therapy can reduce pain and improve daily function in people with chronic low back pain. About 214 adults aged 20-70 with pain lasting at least 3 months will either receive 8 weeks of VR mindfulness sessions plus…

This early-stage study tests a new drug called IBI3002 in adults with asthma. The main goal is to check if multiple doses are safe and tolerable. About 12 to 27 participants will receive either the drug or a placebo by injection. The study lasts about 24 weeks total, including sc…

This study tests whether low-frequency magnetic stimulation to a specific brain area can reduce chronic visceral pain in people with irritable bowel syndrome with diarrhea (IBS-D). 42 adults will receive either real or sham stimulation over two weeks, with both participants and a…

This study looks at the nutritional health of 200 people who have had a stem cell transplant. Researchers will measure body fat, muscle, food intake, and blood protein levels to see how these factors relate to recovery and survival. The goal is to learn how diet might improve lon…

This study looks at whether the temperature of the numbing medicine used in epidurals affects the chance of a mother developing a fever during labor. Researchers will give 424 women either room-temperature or body-temperature anesthetic and track fever rates, pain relief, and hea…

This study looks at how the body breaks down certain carbohydrates (FODMAPs) in the gut and whether that affects graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will follow 100 transplant patients to track when and how severe GVHD occurs. The goal is …