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Why do some ICU survivors never regain strength? new study aims to find out

NCT ID NCT05537298

Recruiting now Knowledge-focused Sponsor: Esther Dupont-Versteegden Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 209 adults who survived a stay in the intensive care unit (ICU) for sepsis or respiratory failure. Researchers will track their muscle strength, physical function, and cellular markers over a year to understand why some patients recover while others do not. The goal is to identify factors that lead to lasting muscle weakness, which could guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could help identify why some ICU survivors struggle to regain muscle strength, pointing toward better rehabilitation strategies.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve outcomes for participants. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Critical Illness critical illness polyneuropathy Muscle Weakness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRITICAL ILLNESS ICU ACQUIRED WEAKNESS MUSCLE WEAKNESS POST INTENSIVE CARE UNIT SYNDROME

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Oklahoma Medical Research Foundation

    ACTIVE_NOT_RECRUITING

    Oklahoma City, Oklahoma, 73113, United States

  • University of Alabama at Birmingham

    ACTIVE_NOT_RECRUITING

    Birmingham, Alabama, 35005, United States

  • University of Kentucky

    RECRUITING

    Lexington, Kentucky, 40536, United States

    Contact

    Contact

    Contact

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

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