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Why do some ICU survivors never regain strength? new study aims to find out

NCT ID NCT05537298

Knowledge-focused Sponsor: Esther Dupont-Versteegden Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 209 adults who survived a stay in the intensive care unit (ICU) for sepsis or respiratory failure. Researchers will track their muscle strength, physical function, and cellular markers over a year to understand why some patients recover while others do not. The goal is to identify factors that lead to lasting muscle weakness, which could guide future treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify why some ICU survivors struggle to regain muscle strength, pointing toward better rehabilitation strategies.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly improve outcomes for participants. Results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 209 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients admitted to ICU for critical illness and expected to survive

Ages

18 years and older

Sex

Male participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult (\>18 y/o) * admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU Exclusion Criteria: * patients who were not ambulatory prior to ICU admission * experienced \>2 ICU admissions in the past year (chronic or recurrent critical illness due to the same or different reason * patients not expected to survive \~6months after admission * acute or chronic neurologic condition * acute or chronic orthopedic condition preventing strength/functional testing * morbid obesity \>50 kg/m2 due to distortion of muscle ultrasonography

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Conditions

The condition(s) this trial relates to.

Critical Illness critical illness polyneuropathy Muscle Weakness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Icu acquired weakness Muscle weakness Post intensive care unit syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Oklahoma Medical Research Foundation

    ACTIVE_NOT_RECRUITING

    Oklahoma City, Oklahoma, 73113, United States

  • University of Alabama at Birmingham

    ACTIVE_NOT_RECRUITING

    Birmingham, Alabama, 35005, United States

  • University of Kentucky

    RECRUITING

    Lexington, Kentucky, 40536, United States

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