MUSCLE WEAKNESS

This early-phase study tests a new treatment called anitocabtagene autoleucel (anito-cel) for people with generalized myasthenia gravis, a condition that causes muscle weakness. Anito-cel is a type of CAR T-cell therapy that targets BCMA, a protein on certain immune cells. The tr…

This study tests whether taking creatine, a common dietary supplement, can help breast cancer survivors regain strength and endurance faster when combined with a 12-week exercise program. Sixty women who recently finished chemotherapy will be randomly assigned to exercise with or…

This study is testing a new leg exoskeleton designed by the NIH to help children and young adults with muscle weakness from conditions like cerebral palsy or spinal cord injury. Researchers want to see how well the device works in different real-world settings, like walking on a …

This study follows 209 adults who survived a stay in the intensive care unit (ICU) for sepsis or respiratory failure. Researchers will track their muscle strength, physical function, and cellular markers over a year to understand why some patients recover while others do not. The…

This study looks at how muscle weakness develops when a wrist is immobilized for 7 days in women aged 40-65. It also tests whether strength training the opposite arm can help maintain muscle and nerve function in the casted arm. Twenty women will wear a wrist cast and either do o…

This study uses non-invasive MRI and MRS scans to measure how well muscle cells produce energy in adults who survived childhood acute lymphoblastic leukemia (ALL). Researchers will compare 60 survivors with low muscle mass to healthy volunteers. The goal is to understand why many…

This study looks at how losing weight changes the fat stored inside your muscles, called intermuscular adipose tissue (IMAT). Researchers want to see if weight loss reduces inflammation and improves how your muscles respond to insulin. Seventy adults with obesity will follow a 12…

This pilot study is looking at why some patients in the intensive care unit (ICU) develop severe muscle weakness after surgery. Researchers will take blood and small muscle samples from 20 high-risk patients to look for chemical changes that might cause or signal this weakness. T…

This study is looking at why some people recover leg strength better than others after surgery for a slipped disc. Researchers will follow 40 patients who have leg weakness before surgery and track factors like age, weight, and how long they had weakness. The goal is to find out …

This study tests whether a type of exercise using a flywheel machine can help prevent muscle loss and weakness during space travel. Sixteen healthy adults who exercise regularly will take part. They will use crutches and a special shoe to mimic the reduced weight-bearing of space…