MUSCLE WEAKNESS

This early-stage study tests a new treatment called anito-cel for people with generalized myasthenia gravis, a condition causing muscle weakness. Anito-cel is a type of CAR-T cell therapy that targets specific immune cells to reduce disease activity. The study will enroll about 3…

This study looks at whether taking creatine supplements can help breast cancer survivors build strength and endurance faster through exercise. Researchers will compare results from 60 women who recently finished chemotherapy with healthy women of the same age. The goal is to impr…

This study looks at whether an 8-week Pilates exercise program can improve breathing in overweight and obese women. About 48 women will be split into an exercise group and a control group. Researchers will measure lung function, breathing rate, and quality of life before and afte…

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat makes muscles less responsive to insulin and causes inflammation, and if weight loss can reverse that. About 70 adults with obesity will follow a 12-…

This study looks at why some patients in the intensive care unit (ICU) get severe muscle weakness after surgery. Researchers will take blood and small muscle samples from 20 high-risk patients to find chemical changes that might cause or predict this weakness. The goal is to lear…

This study looks at whether a specific type of exercise using a flywheel machine can help prevent muscle loss and weakness that happens when people are in space. Researchers will study 16 healthy adults who exercise regularly. They will measure muscle strength, size, and nerve si…

This study follows 40 adults having surgery for a slipped disc in the lower back that causes leg weakness. Researchers want to find out which factors before surgery—like age, diabetes, or how long the weakness lasted—best predict how much strength returns. The goal is to help doc…

This study is testing new ways to use robotic leg braces (exoskeletons) in children and young adults who have muscle weakness from conditions like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury. Participants will try the braces while walking on a treadmil…

This study looks at why some survivors of childhood acute lymphoblastic leukemia (ALL) have weak muscles. Researchers will use MRI scans, ultrasound, and small muscle biopsies to measure how well muscle cells produce energy. The goal is to learn more about the link between cancer…

This study follows 209 adults who survived a stay in the intensive care unit (ICU) for sepsis or breathing failure. Researchers want to understand why some people regain muscle strength and function while others do not. Participants will undergo physical tests and provide muscle …