Shedding light on hidden muscle fat: can weight loss quiet inflammation?
NCT ID NCT06129110
First seen May 08, 2026 · Last updated Jun 20, 2026 · Updated 11 times
Summary
This study looks at how weight loss changes the fat stored inside muscles, called IMAT, in people with obesity. Researchers want to see if losing weight reduces harmful signals from this fat that can lead to insulin resistance and muscle weakness. Seventy participants will follow a 12-week low-calorie diet and undergo tests including muscle biopsies, MRIs, and strength measurements before and after weight loss.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Colorado Anschutz
RECRUITINGAurora, Colorado, 80045, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Low calorie diet of meal replacement shakes
What this could lead to
If successful, this could reveal how fat inside muscles contributes to insulin resistance and muscle weakness, pointing toward new ways to prevent or treat these conditions.
What could go wrong
This is a small, early-stage study focused on understanding mechanisms, not testing a treatment. Results may not apply to everyone, and weight loss may not change the fat signals as expected.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.