INSULIN SENSITIVITY

This study tests whether colchicine, a common anti-inflammatory drug, can improve how well the body responds to insulin in people with type 1 diabetes who have ongoing low-level inflammation. Researchers will measure insulin sensitivity using a special test in 26 adults. The goal…

This study looks at whether replacing sugary drinks with stevia-sweetened ones can help children ages 8 to 12 control their weight and improve metabolic health. About 150 kids who are normal weight or overweight will be randomly assigned to drink stevia, sugar, or water for 8 to …

This study tests a new medicine called retatrutide in adults with type 2 diabetes. The goal is to see if it improves how the body makes and uses insulin after 28 weeks. About 95 people will take part, and the results will be compared to a placebo and another diabetes drug.

This study tests whether a minimally invasive stomach-shrinking procedure (endoscopic sleeve gastroplasty) combined with lifestyle changes is better than lifestyle changes alone for treating a serious liver condition called MASH in people with obesity. The procedure reduces stoma…

This study tests whether giving insulin in short weekly sessions can improve how the body uses sugar and how well people with Alzheimer's think and remember. Eight adults will receive the treatment for six months and take memory tests. The goal is to see if this approach is safe …

This study looks at whether two common artificial sweeteners, aspartame and sucralose, affect blood sugar control in adults aged 40 and older who have prediabetes. Researchers will provide all meals for 8 weeks and use continuous glucose monitors to track blood sugar levels. The …

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat makes muscles less responsive to insulin and causes inflammation, and if weight loss can reverse that. About 70 adults with obesity will follow a 12-…

This study looks at why night shift workers have higher risks for heart disease and diabetes. Researchers will test if eating only during certain hours (time-restricted eating) can improve blood vessel health and insulin sensitivity. The study involves 50 adults who have worked n…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study looks at how a single bout of exercise improves the way muscles respond to insulin in healthy young men. Researchers will measure muscle glucose uptake and analyze protein changes in muscle tissue. The goal is to understand the early signals that make muscles more sens…