Could CAR t-cells tame myasthenia gravis? early trial launches

NCT ID NCT06626919

Recruiting now Disease control Sponsor: Arcellx, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests a new treatment called anitocabtagene autoleucel (anito-cel) for people with generalized myasthenia gravis, a condition that causes muscle weakness. Anito-cel is a type of CAR T-cell therapy that targets BCMA, a protein on certain immune cells. The trial will enroll 30 adults to check safety and see if it improves daily living activities.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: anitocabtagene autoleucel (CAR T-cell therapy)
What this could lead to: If it works, this could point toward a new treatment option for generalized myasthenia gravis that targets the root cause of the disease.
What could go wrong: This is a very early phase 1 trial with only 30 people, so it is too soon to know if it is safe or effective. CAR T-cell therapy can cause serious side effects like cytokine release syndrome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune disease autoimmune disorder of the nervous system muscle tissue disorder Muscle Weakness myasthenia gravis Neuromuscular Manifestations

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE AUTOIMMUNE DISEASES AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM MUSCLE WEAKNESS MUSCULAR DISEASES MYASTHENIA GRAVIS NEUROMUSCULAR MANIFESTATIONS

Contacts and locations

Locations

Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43221, United States
Oregon Health & Science University (OHSU)
RECRUITING

Portland, Oregon, 97239, United States
Stanford Hospital
RECRUITING

Palo Alto, California, 94305, United States
Temple University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19140, United States
UCLA Medical Center
RECRUITING

Los Angeles, California, 90095, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of California, Irvine
RECRUITING

Orange, California, 92602, United States
University of Minnesota Delaware Clinical Research Unit
RECRUITING

Minneapolis, Minnesota, 55414, United States
University of South Florida - Carol and Frank Morsani Center of Advanced Healthcare
RECRUITING

Tampa, Florida, 33612, United States

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