Liquid nerve biopsy could unlock ALS secrets

NCT ID NCT07268833

Recruiting now Knowledge-focused Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms appear. The goal is to develop reliable tests and uncover new targets for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to reliable tests for earlier ALS diagnosis and better ways to track disease progression, and may point to new treatment targets.
What could go wrong: This is an observational study, not a treatment trial. It is still in early stages, and the biomarkers discovered may not prove useful in practice or lead directly to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease amyotrophic lateral sclerosis frontotemporal dementia Lewy body dementia motor neuron disorder Nerve Degeneration Parkinson disease peripheral nervous system disorder peripheral neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMYOTROPHIC LATERAL SCLEROSIS (ALS) PERIPHERAL NEUROPATHIES

Contacts and locations

Locations

Azienda Ospedaliera Universitaria Federico II
RECRUITING

Naples, 80131, Italy
Azienda Ospedaliero Universitaria di Cagliari
RECRUITING

Monserrato, California, 09042, Italy
Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, Italy
IRCCS Ospedale San Raffaele SRL
RECRUITING

Milan, Italy

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