Liquid nerve biopsy could unlock ALS secrets

NCT ID NCT07268833

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms appear. The goal is to develop reliable tests and uncover new targets for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to reliable tests for earlier ALS diagnosis and better ways to track disease progression, and may point to new treatment targets.

What could go wrong

This is an observational study, not a treatment trial. It is still in early stages, and the biomarkers discovered may not prove useful in practice or lead directly to therapies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease amyotrophic lateral sclerosis frontotemporal dementia Lewy body dementia motor neuron disorder Nerve Degeneration Parkinson disease peripheral nervous system disorder peripheral neuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Azienda Ospedaliera Universitaria Federico II

    RECRUITING

    Naples, 80131, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Azienda Ospedaliero Universitaria di Cagliari

    RECRUITING

    Monserrato, California, 09042, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Fondazione IRCCS Istituto Neurologico Carlo Besta

    RECRUITING

    Milan, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • IRCCS Ospedale San Raffaele SRL

    RECRUITING

    Milan, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••