Fondazione I.r.c.c.s. Istituto Neurologico Carlo Besta

This study tests whether focused ultrasound, a non-invasive procedure that creates a tiny lesion in a brain region controlling movement, can safely reduce symptoms of limb dystonia in adults who haven't responded to medications or botulinum toxin. Participants are randomly assign…

This study tests whether a daily postbiotic supplement (PostbiotiX Comfort®) can improve gut and behavioral symptoms in 90 children aged 3-8 with autism. Researchers will check stomach issues, sleep, and behavior before and after one month of treatment. The goal is to see if impr…

This study compares Botox injections guided by ultrasound versus standard injections (using body landmarks) in 100 adults with cervical dystonia, a condition causing painful neck muscle spasms. Participants will receive both types of injections at different times and complete que…

This study looks at whether using lower doses of anesthesia during brain tumor surgery helps patients wake up more quickly and safely after the operation. Researchers will track 100 adults having elective brain surgery and measure how well they recover consciousness. The goal is …

This study is testing whether a blood or urine test can detect signals from brain tumors, especially glioblastoma. Researchers will use a special dye (5-ALA) that makes tumor cells glow during surgery to help link what's seen in the blood to the actual tumor. The goal is to devel…

This study looks at epigenetic changes in meningioma, a common brain tumor, to find markers that might predict if the tumor will come back. Researchers will analyze tissue and blood samples from 210 patients to develop a personalized risk profile. The goal is to improve follow-up…

This study is testing a new fiber optic system that fits inside a standard biopsy needle to help doctors see tumor tissue and blood vessels during brain surgery. The goal is to make biopsies for high-grade glioma safer and more accurate. The study involves 20 adults whose surgery…

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will check if the Italian version works well by testing it with 190 patients across multiple centers. The goal is to help doctors better …

This study listens directly to patients with a slow-growing brain tumor (IDH-mutant grade 2 glioma) to understand how different treatments affect their quality of life, symptoms, and anxiety. About 90 adults will either receive radiotherapy, the drug vorasidenib, or no active tre…

This study is testing whether a special dye, called sodium fluorescein, can help surgeons see brain tumors more clearly during surgery. The dye is injected into the bloodstream and collects in the tumor, making it glow under a special microscope. The goal is to see if this helps …

This study looks at how cholesterol and its byproducts may be linked to the development and worsening of dementias like Alzheimer's. Researchers will measure these substances in brain tissue, spinal fluid, and blood from 80 adults aged 40-85 with different types of dementia. The …

This study aims to improve the diagnosis and understanding of rare cerebrovascular diseases (rCVDs) like CADASIL, Fabry disease, and Moyamoya. Researchers will collect detailed health information from 500 participants across Italy to describe the diseases' features and natural hi…

This study is testing a smartphone app that creates a "digital twin" of you to help manage your health after a stroke or related condition. Researchers want to see if people find the app useful and easy to use for preventing future problems. About 20 adults will use the app along…

This study looks at how a type of brain tumor (parietal lobe glioma) affects a person's ability to pay attention to space and objects. Researchers will test 40 patients before and after surgery to see how these skills change. The goal is to better understand these thinking proble…

This study is collecting information from 4500 people who need brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find out what factors help predict how well someone will recover after surgery. By standardizing how outcomes are …

This study looks at ways to better diagnose and treat people with drug-resistant focal epilepsy, a condition where seizures start in one part of the brain and don't respond to medication. About 337 adults will be followed to see how well different treatments—like surgery, focused…

This study looks at how deep brain stimulation (DBS) affects brain networks in people with dystonia, a movement disorder. Researchers will use brain scans and electrical recordings from the brain to understand changes over time. The goal is to learn more about the condition and p…

This study is gathering information from 500 people with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain and memory problems in older adults. Researchers want to better understand how the disease progresses and find markers that could improve diag…

This study looks at the mental health, emotions, and quality of life of 180 adults with hard-to-treat focal epilepsy who are eligible for brain surgery. Researchers will track changes in mood, anxiety, irritability, and other psychological factors before and after surgery. The go…

This study is looking for genetic clues that might help predict whether a brain aneurysm will rupture. Researchers will collect blood samples and medical information from 252 people with brain aneurysms (some ruptured, some not) and healthy volunteers. The goal is to create a too…

This study aims to find better ways to detect and track ALS early by studying nerve tissue and blood from 400 people with ALS or related nerve conditions. Researchers will use advanced techniques to identify molecular changes that happen before symptoms worsen. The goal is to dis…

This study aims to better understand autism by collecting skin cells from 100 children aged 3-15 with autism and turning them into stem cells in the lab. Researchers will study how these cells behave, especially brain-like immune cells, to learn what goes wrong in autism. No trea…

This study looks at how nerves send signals in people with Charcot-Marie-Tooth disease and other nerve disorders like CIDP. Researchers will use special electrical tests and ultrasound to measure nerve function and size. The goal is to find better ways to tell these conditions ap…

This study will follow 1,000 people of all ages who are getting a minimally invasive procedure (endovascular treatment) for brain or spine blood vessel problems like aneurysms or AVMs. Researchers will track how safe and effective the procedure is, note any complications, and mea…

This study follows 50 children with PTEN gene changes to learn how often they develop tumors. Participants get yearly check-ups including blood tests, ultrasounds, and skin exams for 5 years. The goal is to create better monitoring guidelines for these children and compare their …