Scientists hunt for hidden signs of ALS and FTD in skin and tears

NCT ID NCT06856850

Recruiting now Knowledge-focused Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint' that helps doctors diagnose earlier and track how the disease progresses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better, earlier diagnosis of ALS and FTD and help track disease progression more accurately.
What could go wrong: This is an early-stage observational study, not a treatment trial. The biomarkers identified may not prove useful in real-world clinical settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis frontotemporal dementia pseudotumor cerebri psychiatric disorder semantic dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALS - AMYOTROPHIC LATERAL SCLEROSIS FRONTOTEMPORAL DEMENTIA (FTD) FTD IDIOPATHIC INTRACRANIAL HYPERTENSION NEUROPATHIC PSYCHIATRIC DISORDERS

Contacts and locations

Locations

Azienda Ospedaliero Universitaria di Sassari
NOT_YET_RECRUITING

Sassari, 07100, Italy
Consorzio Interuniversitario Risonanze Magnetiche Metallo Proteine (CIRMMP)
NOT_YET_RECRUITING

Sesto Fiorentino, 50019, Italy
Fondazione IRCCS Istituto Neurologico Carlo Besta
RECRUITING

Milan, 20133, Italy
Università degli Studi di Napoli "Federico II"
NOT_YET_RECRUITING

Naples, 80131, Italy

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