Pseudotumor cerebri

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This study is for people with idiopathic intracranial hypertension (IIH) who have been on the drug acetazolamide for over a year without enough relief. It tests whether placing a small stent in a narrowed brain vein can lower the pressure and improve symptoms like headache and vi…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests whether placing a small tube (stent) in a narrowed brain vein works better than standard medication for people with idiopathic intracranial hypertension (high pressure in the brain). About 74 adults with this condition and a narrowed vein will be randomly assigne…

This study compares two invasive procedures—venous sinus stenting and a neurosurgical shunt—for treating idiopathic intracranial hypertension, a condition that causes high pressure in the brain and can lead to vision loss. The trial will enroll 276 adults who have not improved wi…

This study tests whether placing a small stent in a narrowed brain vein can reduce high pressure inside the skull and improve symptoms like vision loss, headache, and tinnitus. About 114 adults with newly diagnosed idiopathic intracranial hypertension will be randomly assigned to…

This study tests whether a video camera that records the back of the eye can estimate pressure inside the skull without needles, anesthesia, or touching the eye. About 90 adults who already have a standard pressure monitor in place will participate. If successful, this could lead…

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study looks at why some cancer patients develop neurological problems after receiving immunotherapy drugs called checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to find immune cells that may mistakenly attack the nervous system. T…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study tracks 25 adults with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull causes headaches and vision problems. Researchers will measure body mass index (BMI) every three months and see how it relates to the success of treatment…

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint'…

This study collects blood, clots, and tissue from up to 1000 people having procedures for stroke or other blood vessel problems in the brain. Researchers will analyze these samples to find biological markers and understand inflammation. The goal is to learn more about how stroke …

This pilot study aims to see if a special MRI sequence can detect lymphatic damage in people with brain vein narrowing or clots. About 100 adults will get an extra MRI scan during their regular care. No new treatment is tested; the goal is to learn if this MRI method can spot lym…

This study tests a special microscope attachment called GLOW800 that helps surgeons see blood flow and tissues in real time during brain and reconstructive surgery. About 29 adults will take part, and surgeons will rate how well the tool works. The goal is to confirm the device i…

This early study is testing whether a robot can help doctors perform delicate brain blood vessel procedures, such as angiography, embolization, and thrombectomy. Ten patients scheduled for these standard procedures will have them done using a robotic system instead. The main goal…

This study is testing a new, noninvasive eye test called chromatic multifocal pupillometry to see if it can detect vision problems in people with pseudotumor cerebri (PTC), a condition where increased pressure in the skull can damage the optic nerve and cause vision loss. Researc…