Intracranial hypertension

This pilot study tests whether a sleep health program designed for couples can improve sleep and blood pressure. Fifty couples will take part in an 8-week program that includes sleep education, coaching, and a Fitbit to track sleep. The goal is to see if working together as a tea…

This early-stage trial tests whether draining fluid from the spine (external lumbar drainage) is safe and doable for people with severe traumatic brain injury who have high pressure inside the skull. Thirty adults aged 18-65 will receive either standard care alone or standard car…

This study compares two fluids—sodium lactate and a concentrated saline solution—in 40 adults with septic shock. The goal is to see which one better supports blood flow and acid balance. Participants will receive either fluid in a double-blind setup, and researchers will measure …

This study is for people with idiopathic intracranial hypertension (IIH) who have been on the drug acetazolamide for over a year without enough relief. It tests whether placing a small stent in a narrowed brain vein can lower the pressure and improve symptoms like headache and vi…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests whether placing a small tube (stent) in a narrowed brain vein works better than standard medication for people with idiopathic intracranial hypertension (high pressure in the brain). About 74 adults with this condition and a narrowed vein will be randomly assigne…

This study compares two invasive procedures—venous sinus stenting and a neurosurgical shunt—for treating idiopathic intracranial hypertension, a condition that causes high pressure in the brain and can lead to vision loss. The trial will enroll 276 adults who have not improved wi…

This study tests whether placing a small stent in a narrowed brain vein can reduce high pressure inside the skull and improve symptoms like vision loss, headache, and tinnitus. About 114 adults with newly diagnosed idiopathic intracranial hypertension will be randomly assigned to…

This study is testing whether a simple ultrasound of the optic nerve can quickly detect brain swelling and inflammation in ICU patients with conditions like meningitis, encephalitis, or stroke. Researchers will measure the optic nerve sheath diameter in 200 adults and compare it …

This study tests whether a video camera that records the back of the eye can estimate pressure inside the skull without needles, anesthesia, or touching the eye. About 90 adults who already have a standard pressure monitor in place will participate. If successful, this could lead…

This study tests a device called CPMX3 that measures pressure in a small vein near the eye to estimate pressure inside the skull. Currently, measuring brain pressure requires surgery to place a probe inside the head, which carries risks like infection and bleeding. The trial will…

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This study tests whether giving HIV prevention pills (PrEP) to people right in the emergency room helps them start and stay on prevention. Researchers will enroll 250 HIV-negative adults at risk for HIV in Dallas. Participants get a 30-day pill supply and a clinic appointment to …

This study tests an online program called UPDOs Protective Styles to help Black women in the southeastern US learn about and start using PrEP, a medicine that prevents HIV. Researchers will recruit 1000 participants from 32 beauty salons in areas with high HIV rates. One group wi…

This study tests a program to help Black women in Baltimore start taking PrEP, a medication that prevents HIV. The program addresses challenges like intimate partner violence and racism that can make it hard to get PrEP. About 300 Black women who are HIV-negative and at risk will…

This study is testing a new data dashboard to help clinics in Alabama track and improve how they provide PrEP, a daily pill that prevents HIV. The dashboard shows real-time data on PrEP prescriptions and patient needs, aiming to reduce racial gaps in HIV prevention. Researchers w…

This study tests a program in the Dallas County Jail that identifies people at high risk for HIV and offers them testing and education about PrEP, a daily pill that prevents HIV. A patient navigator helps interested individuals connect with PrEP providers after they are released.…

This study will follow 5,000 HIV-negative adults in Italy who are taking PrEP, a daily pill that prevents HIV. Researchers want to see how well PrEP works in real life, how many people stick with it, and what barriers they face. The goal is to use this information to improve HIV …

This early study tests whether a peptide called IRW, found in egg white hydrolysate, can help manage high blood sugar and blood pressure. About 28 participants at risk for or with type 2 diabetes will consume a smoothie with the peptide on four separate days, while a healthy cont…

This study will compare two types of heart-lung machines used during coronary bypass surgery to see how they affect blood flow to the brain. Researchers will measure brain pressure using an eye ultrasound and brain oxygen levels with a forehead sensor in 70 patients. The goal is …

This study looks at why some cancer patients develop neurological problems after receiving immunotherapy drugs called checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to find immune cells that may mistakenly attack the nervous system. T…

This study looks at the best way to treat a fluid pocket (pseudomeningocele) that can form under the scalp after brain surgery. It compares doing nothing active (just watching and caring for the wound) with doing a procedure like draining the fluid or another surgery. The goal is…

This study is for 12 adults with severe brain injuries or tumors in the back part of the brain. Doctors will place two small pressure sensors to measure pressure in both the front and back of the brain. The goal is to learn what normal and dangerous pressure levels are in the bac…

This study tracks 25 adults with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull causes headaches and vision problems. Researchers will measure body mass index (BMI) every three months and see how it relates to the success of treatment…

This study is testing a new device that measures pressure inside the skull without needing surgery. The device uses a small pin on the head to detect tiny skull movements with each heartbeat. Researchers want to see if this non-invasive method can give useful information similar …

This study wants to improve how we measure children's recovery and experience after surgery and anesthesia. Researchers will translate and test a recovery scale for Danish children aged 4-12, and also develop a new questionnaire that lets children describe their own hospital expe…

This study aims to find biological markers (biosignatures) in people with ALS and FTD to make diagnosis more precise. Researchers will analyze samples like spinal fluid, skin, and tears from 230 participants using advanced techniques. The goal is to create a 'disease fingerprint'…

This pilot study aims to see if a special MRI sequence can detect lymphatic damage in people with brain vein narrowing or clots. About 100 adults will get an extra MRI scan during their regular care. No new treatment is tested; the goal is to learn if this MRI method can spot lym…

This study looks at eye problems in people with craniosynostosis, a condition where skull bones close too early. Researchers will check for issues like crossed eyes, lazy eye, and pressure inside the head. The goal is to better understand these eye problems to help improve care.

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study is testing a new, noninvasive eye test called chromatic multifocal pupillometry to see if it can detect vision problems in people with pseudotumor cerebri (PTC), a condition where increased pressure in the skull can damage the optic nerve and cause vision loss. Researc…

This study is testing a new monitor that tracks brain pressure over time in patients with serious brain injuries like trauma or bleeding. Researchers want to see if the pressure measurements can predict who will survive or recover well. The study will enroll 250 adults and follow…

This study looks at whether asking patients with advanced lung cancer to fill out regular questionnaires about their quality of life, symptoms, and mental health can help doctors understand which treatment works best. About 144 people will complete online surveys before, during, …