Neurovascular disorder

This trial investigates a 'maximal medical treatment' bundle for people with intracerebral hemorrhage (bleeding in the brain). The bundle includes rapid blood pressure control, reversal of blood thinners, and a drug to reduce bleeding, all delivered within the first 72 hours in a…

This study looks at people with narrowed carotid arteries who are getting a stent. Some people do not respond well to the common blood thinner clopidogrel. The study compares giving these 'non-responders' a different drug, ticagrelor, versus continuing clopidogrel in those who re…

This study tests an experimental drug called THN391, given as an injection into the eye, for people with diabetic macular edema (DME) — a condition where fluid builds up in the retina due to diabetes, causing vision loss. The trial involves 21 adults aged 18 to 80 with DME and vi…

This study tests a new device called the RapidPulse Aspiration System, which uses precisely timed suction to remove blood clots from brain arteries in people having a severe stroke. The trial will enroll 170 adults aged 18 to 80 who can be treated within 8 hours of stroke symptom…

This study tests a new drug called ASP2246 for adults who have trouble moving after a stroke. In the first part, small groups get increasing doses via brain surgery to check safety. In the second part, some get the drug and others get a sham surgery, with neither patient nor doct…

This study tests a new virtual reality (VR) walking therapy for people who have had a stroke within the past 1 to 6 months. Participants will use either a fully immersive VR system that lets them walk over ground in realistic environments, or a semi-immersive VR system on a tread…

This study tests a one-time gene therapy called surabgene lomparvovec (Sura-vec) for diabetic retinopathy, a common eye problem from diabetes that can lead to blindness. About 576 adults with moderate-to-severe non-proliferative diabetic retinopathy will receive either the gene t…

This trial compares two types of surface-modified flow diverters—special stents used to treat unruptured brain aneurysms. The goal is to see which device causes fewer small brain injuries (seen on MRI) and fewer stroke-like symptoms after the procedure. About 196 people with unru…

This phase 3 trial is testing atogepant, a daily pill already approved for adults, to prevent episodic migraines in children aged 6 to 17. About 450 participants will receive either a low or high dose of the drug or a placebo for 12 weeks. The goal is to see if it safely reduces …

This study tests whether rimegepant, a dissolving tablet, can prevent migraines in children and adolescents ages 6 to under 18. About 640 participants will receive either the drug or a placebo for 12 weeks. The main goal is to see if the drug reduces the number of migraine days p…

This study tests whether starting a special exercise program soon after a stroke can protect the brain from memory loss and dementia. Researchers will enroll 120 people who had a stroke in the past 6 months. Participants will do a mix of exercises, and the study will measure chan…

This study tests whether the antibiotic minocycline can improve recovery in people having an ischemic stroke. About 934 adults will receive either minocycline or a placebo, in addition to standard clot-busting medication. The goal is to see if minocycline leads to better function…

This study tests a device called Artisse, which is placed inside a brain aneurysm to block blood flow and prevent rupture. It involves 300 people aged 18-75 with wide-neck aneurysms that are either unruptured or recently ruptured. The main goal is to see if the device safely and …

This study tests an implanted device that stimulates nerves at the back of the head to prevent chronic cluster headaches. Ten adults with difficult-to-treat cluster headaches will receive the implant and use it daily for 48 weeks. Researchers will track side effects and whether t…

This study tests whether giving a second dose of the clot-busting drug prourokinase can help stroke patients who have a blocked medium or large artery and don't show improvement one hour after the first dose. About 122 adults will be enrolled within 4.5 hours of stroke onset. The…

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

This study tests whether the drug ubrogepant can prevent menstrual migraines when taken daily for a week around each period. About 496 women with regular cycles and a history of menstrual migraines will receive either ubrogepant or a placebo for three cycles, then all may receive…

This early-phase study tests whether adding melatonin to standard cooling therapy can improve brain outcomes in newborns with hypoxic-ischemic encephalopathy (HIE), a condition caused by oxygen loss at birth. About 70 full-term infants will receive different doses of melatonin to…

This study tests a new device called CLAAS that is placed in the heart to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 1600 participants will be randomly assigned to get either the new device or one of two already-approved devices. The goal i…

This study tests whether giving the drug milrinone directly into the brain's arteries, followed by a 72-hour IV drip, can prevent brain damage in people who develop artery spasms after a bleeding stroke from a burst aneurysm. The trial will enroll 306 adults across multiple hospi…

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency a…

This study tests a new device and technique (ADAPT 2.0) for removing blood clots in people having an acute ischemic stroke. The goal is to see if it can restore blood flow more completely and safely than current methods. About 750 adults who are already scheduled for clot removal…

This early-stage trial compares a new investigational drug, CG-0255, to the established blood thinner Plavix in 136 healthy adults aged 18-55. The goal is to see if CG-0255 is processed by the body similarly to Plavix and has the same effect on preventing blood clots. Participant…

This study tests whether starting virtual reality-based rehabilitation within 24 hours of an acute ischemic stroke can improve arm muscle strength, thinking skills, and motivation to exercise. One hundred adults recently diagnosed with stroke will be randomly assigned to either v…

This pilot study explores whether taking high-dose cocoa extract supplements is feasible and acceptable for people with episodic migraine. Researchers will compare two doses of cocoa extract to a placebo, tracking how many participants stick with the daily pills for 12 weeks. The…

This trial tests whether removing a brain bleed with a minimally invasive scope within hours of symptoms improves recovery. 300 adults with a specific type of brain bleed will be randomly assigned to either get the surgery plus standard care, or standard care alone. The study wil…

This study tests a structured problem-solving approach called CO-OP (Cognitive Orientation to daily Occupational Performance) for adults who have had a stroke or traumatic brain injury. Participants learn a 'Goal-Plan-Do-Check' strategy to tackle everyday tasks like dressing or c…

This study tests whether the drug clevidipine can lower blood pressure quickly and steadily in people having a bleeding stroke (intracerebral hemorrhage). High blood pressure can make the bleeding worse, so getting it under control fast is critical. The trial will compare clevidi…

This phase 3 trial tests whether a shorter, lighter course of corticosteroids (28 weeks) works as well as the standard longer course (52 weeks) for giant cell arteritis, a condition that inflames blood vessels. The study aims to reduce side effects from long-term steroid use. 150…

This study tests a new device called EmStop that captures debris during a heart valve replacement procedure (TAVR) for aortic stenosis. About 663 people will be randomly assigned to receive either the EmStop device or a standard device. The goal is to see if EmStop reduces the ri…

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study looks at whether adding a blood thinner to standard antiplatelet therapy helps prevent strokes and blood clots in people who develop a new, temporary irregular heartbeat after coronary artery bypass surgery. About 3,200 adults who had bypass surgery and then experience…

This trial tests a new clothing-like robotic arm that detects muscle signals to help people who have had a stroke move their arm and hand. The device supports coordinated movements of the shoulder, elbow, wrist, and fingers during 20 one-hour training sessions. The study includes…

This study is testing whether a lower dose of the clot-busting drug tenecteplase is safer and just as effective as the standard dose for treating acute ischemic stroke in people aged 70 and older. About 798 participants will receive either a low dose (0.175 mg/kg) or the standard…

This study compares two rehabilitation techniques—mirror therapy and modified constraint-induced movement therapy—to see which better improves arm function in people who had a stroke. Sixteen participants with hemiplegia (weakness on one side) will be randomly assigned to one of …

This study tests whether adding GM1, a natural brain substance, to standard clot-removal treatment helps people recover better after a severe stroke. About 868 adults in China who have a blocked artery in the front part of the brain will receive either GM1 or a placebo daily for …

This study tests whether the drug sivelestat sodium, given alongside standard clot-removal surgery, can help people recover better after a major stroke. The trial will include 868 adults aged 18-80 with large-vessel blockage in the front part of the brain. The goal is to see if t…

This study tests an oral medication called BI 1815368 in 300 adults with center-involved diabetic macular edema, a common cause of vision loss in diabetes. Participants take tablets twice daily for about 11 months, and doctors compare vision changes between those on the drug and …

This study is testing a device called a flow modulator to treat wide-necked brain aneurysms. The device is placed inside the artery to redirect blood flow away from the aneurysm, helping it close off. Researchers will check if the device is safe and effective in 214 adults over 1…

This phase 3 trial tests whether Xeomin (a botulinum toxin type A injection) can reduce the number of migraine days in people with chronic migraine. About 780 participants will receive either Xeomin or a placebo injected into head and neck muscles every 12 weeks for up to 55 week…

This Phase 3 trial tests whether the drug tirofiban can help people who have had a stroke but missed the usual treatment window (more than 24 hours after symptoms start). The study uses a special MRI scan to select patients whose stroke is caused by a specific type of artery bloc…

This study tests a new medicine called BI 3812465 for people with diabetic macular edema, a condition that causes swelling in the center of the eye and can lead to vision loss. The trial has two parts: first, a small group gets low to high doses to check safety, then a larger gro…

This study tests whether using a nicardipine infusion (a fast-acting blood pressure drug) can help more stroke patients with brain bleeding reach a safe blood pressure within one hour of arriving at the hospital. About 88 adults with acute intracerebral hemorrhage and high blood …

This study follows 118 people getting a special device called Pipeline Vantage to treat brain aneurysms. The device is placed inside the blood vessel to block the aneurysm and prevent rupture. Researchers will check how well it works and if there are any problems one year after t…

This real-world study is following 7,000 Chinese adults with established heart disease to see if adding Repatha® (a cholesterol-lowering injection) to their usual care reduces major cardiovascular events like heart attacks, strokes, and heart-related death. Participants are eithe…

This study explores whether a robotic device that amplifies a person's own walking movements can help improve balance in people who have had a stroke. Participants with chronic stroke (more than 6 months ago) will do two treadmill walking sessions—one in a normal environment and …

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This study tests a traditional Chinese medicine called Jiedu Huayu oral prescription in 436 people who have had a brain bleed due to a condition called cerebral amyloid angiopathy. The goal is to see if the herbal treatment can lower the chance of having another stroke or blood v…

This study tests a daily pill called orforglipron to see if it can prevent major heart problems (like heart attacks or strokes) and slow kidney disease in people who already have heart or kidney disease. About 7,140 adults will take either the drug or a placebo for up to 5 years.…

This study tests whether giving caffeine to newborns with hypoxic ischemic encephalopathy (HIE) can reduce death or long-term disability. HIE is a brain injury caused by lack of oxygen around birth. The trial will enroll 830 full-term infants and give them either caffeine or a pl…

This early-stage trial tests an experimental drug called RO7663498, given as an injection into the eye, for people with diabetic retinopathy. The main goal is to check safety and how the drug moves through the body. About 30 participants will receive multiple doses to see if it i…

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achi…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study tests whether breathing in a safe, inexpensive gas called argon during carotid artery surgery can prevent brain damage and confusion after the operation. About 100 adults having elective carotid surgery will be randomly assigned to receive either argon gas or a placebo…

This Phase 2 trial tests an experimental drug called EYE103 (Restoret) in 160 people with wet age-related macular degeneration or macular edema from a branch retinal vein occlusion. Participants receive three eye injections of either a low or high dose of EYE103, spaced four week…

This study compares a new 'virtual stroke unit' approach to standard stroke unit care for people with a stroke who are not eligible for a clot removal procedure. The virtual unit uses video calls and monitoring equipment to let a specialist team at a main hospital help guide care…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This early-stage trial tests an experimental drug called RO7823653, given as an eye injection alone or with an approved drug (faricimab), for people with diabetic macular edema—a condition where diabetes causes fluid buildup and vision loss in the center of the eye. The study wil…

This study tests whether pemafibrate, a drug that lowers triglycerides, can prevent the worsening of narrowed brain arteries in people who have already had a stroke or mini-stroke. About 270 participants will be randomly assigned to receive either pemafibrate plus standard care o…

This study tests a drug called tenecteplase (TNK) for people who have had a stroke caused by a blood clot in the brain. The drug is given up to 24 hours after symptoms start, using only a simple CT scan to decide who can get it. The goal is to see if TNK helps people recover bett…

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This study tests a new device called CHORDS that catches loose debris during a heart valve replacement procedure (TAVR). The debris can travel to the brain and cause a stroke. The trial will compare CHORDS to an existing device in 240 people with severe aortic stenosis. Participa…

This study tests two ways to treat proliferative diabetic retinopathy, a serious eye problem caused by diabetes. One group gets eye injections of faricimab plus laser treatment; the other gets vitrectomy surgery with laser. Researchers will track vision and how many extra treatme…

This study tests a new eye injection called KIO-104 for people with macular edema, a condition where fluid builds up in the eye and blurs vision. About 28 adults will receive multiple doses to see if the drug is safe and helps reduce swelling. The goal is to find a steroid-free o…

This study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…

This study tests whether eptinezumab, given as an IV infusion, can reduce the number of migraine days in adolescents aged 12 to 17 who have chronic migraine (15 or more headache days per month). Participants will receive either the drug or a placebo (salt water) and track their h…

This study compares two blood thinner strategies after left atrial appendage closure (LAAC) in people with atrial fibrillation. Sixty participants will receive either aspirin alone or aspirin plus clopidogrel for three months. The goal is to see which approach better prevents sma…

This study tests the long-term safety of eptinezumab (Vyepti) in 600 children and teens aged 6 to 17 with chronic or episodic migraine. Participants must have completed a prior study. The main goal is to track side effects over time, with additional measures of drug levels and im…

This study tests whether eptinezumab, given through a vein, can safely reduce the number of migraine days in children and teens aged 6 to 17 with episodic migraine. Participants receive either the drug or a placebo, and researchers track monthly migraine days over 12 weeks. The g…

This Phase 3 study tests whether taking rimegepant (a dissolving tablet) for 7 days around each period can prevent menstrual migraines in women aged 18-45. About 723 women with regular cycles and a history of menstrual migraines will receive either rimegepant or a placebo. The go…

This study is testing whether the drug rimegepant, taken as a tablet every other day, can help prevent migraines in adults who have at least four migraine days per month. Researchers will track changes in migraine frequency over three to twelve months. The goal is to see if rimeg…

This study tests whether the Luna EMG rehabilitation robot can help people who had a stroke more than a year ago improve arm movement. Five participants will use the robot for 30 minutes per session as part of their rehab. The goal is to see if the robot can make arm movements sm…

This study tests whether using a special bladder catheter that continuously measures body temperature can help guide treatment and improve recovery in people with severe brain bleeding. About 318 participants will be randomly assigned to either continuous bladder temperature moni…

This study tests whether removing a blood clot from the brain up to 72 hours after a stroke can help patients recover better than standard care. About 336 adults with severe strokes due to a large vessel blockage will be randomly assigned to get the clot removal procedure or usua…

This study tests whether adding a PCSK9 inhibitor (Recaticimab) to standard statin therapy can reverse plaque buildup in brain arteries of people with asymptomatic intracranial atherosclerosis. About 300 participants will receive either the drug combo or statins alone for 24 week…

This study will follow 2,641 people with episodic or chronic migraine to see how well newer drugs—like monoclonal antibodies, gepants, ditans, and a sumatriptan-naproxen combo—work in everyday life. Researchers will track monthly migraine days, pain relief within 2 hours, and any…

This study looks at how well a device called WEB works for treating brain aneurysms (weak spots in blood vessels) in real-life medical practice. It will include 1,000 people of any age who have had this device placed. The main goals are to see if the aneurysm is sealed off at 12 …

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This Phase 3 trial tests a drug called Fortelyzin® (non-immunogenic staphylokinase) in 990 adults with acute ischemic stroke who can be treated between 4.5 and 24 hours after symptoms begin. Participants receive a single injection of the drug or a placebo. The goal is to see if t…

This study tests whether infliximab (Remicade), a drug used for arthritis and other inflammatory conditions, can shrink a specific type of brain aneurysm called a dolichoectactic vertebrobasilar (DVB) aneurysm. These aneurysms are difficult to treat with surgery or stents, and th…

This study tests an experimental drug called ALN-APP in 200 adults with cerebral amyloid angiopathy (CAA), a condition that causes bleeding in the brain. The drug is given via spinal injection and aims to slow disease progression and reduce new brain bleeds. Participants will be …

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

This study tests whether implanting small filters in the carotid arteries (the main neck arteries) can prevent repeat strokes in people with atrial fibrillation who have already had a stroke. Participants will receive the filters plus standard blood thinners, or blood thinners al…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with chronic stroke move their arms and legs again. Only 3 participants will be implanted with electrodes on the brain and spine. The main goal is to check safety, but researche…

This study compares two treatments for a severe type of stroke caused by a blockage in a major artery at the base of the brain. Some patients will get a clot-busting drug through a vein followed by a procedure to remove the clot, while others will have the clot removal procedure …

This study tests whether the clot-busting drug tenecteplase can help people who have a stroke more than 4.5 hours ago, including those who wake up with stroke symptoms. About 1,325 adults with brain imaging showing salvageable tissue will be randomly assigned to receive tenectepl…

This study is testing a medical device called the Penumbra System in 200 adults aged 18-75 who have had a severe stroke caused by a blocked artery. The device is used to remove the clot and restore blood flow to the brain. The main goal is to see how well and how safely the devic…

This trial investigates whether people with diabetic macular edema can safely monitor their vision and eye health at home instead of making frequent hospital visits. Participants use a home vision tester and a portable eye scanner every four weeks, with results sent to their doct…

This study compares two treatment strategies for elderly frail patients with atrial fibrillation (AF) who are at high risk for both stroke and bleeding. One group receives catheter ablation plus a device to close the left atrial appendage (LAAO), while the other receives ablation…

This early-stage trial tests whether stem cells from the placenta, given through an IV, are safe and might help people recover from a recent stroke. About 24 participants will receive either the stem cells or a placebo. Researchers will track their recovery over two years, focusi…

This study tests whether blocking a small artery in the brain (the middle meningeal artery) with a special glue can prevent chronic migraines. About 70 adults with hard-to-treat chronic migraine will receive the procedure. The main goal is to see if it safely reduces the number o…

This study tests whether a clot-busting drug called tenecteplase can help people who have a stroke affecting the back part of the brain. Participants must start treatment between 4.5 and 24 hours after their first symptoms. The goal is to see if the drug improves recovery and dai…

This study tests whether N-acetyl cysteine (NAC), a safe supplement, can reduce oxidative stress and improve eye health in people with type 2 diabetes who have mild to moderate diabetic retinopathy. About 76 adults aged 18-70 will take NAC to see if it lowers damage to blood vess…

This study tests whether the drug atogepant (Qulipta) can safely prevent chronic migraines in teenagers aged 12 to 17. About 420 teens with chronic migraine will take either atogepant or a placebo pill daily for 12 weeks. Researchers will track side effects and changes in monthly…

This study tests a nurse-led program called BEST CARE ICTUS_HC for adults hospitalized with acute stroke in hospitals without specialized stroke units. The program includes staff training, swallowing tests, and environmental adaptations to help with attention and safety. Research…

This study tests a new device called the Adaptive Tip Catheter for removing blood clots in people having a severe stroke. About 74 adults will receive the catheter procedure within 24 hours of stroke symptoms. The goal is to see if the device can restore blood flow in the brain w…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study compares two exercise programs—sensorimotor training and dual-task training—against standard physical therapy for stroke survivors. The goal is to see which approach best improves balance, mobility, and reduces fall risk. Fifty-four participants who had a stroke at lea…

This study tests whether giving hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) soon after emergency clot removal can improve recovery in people with severe stroke. Researchers plan to enroll 420 adults aged 18–80 who had a large-vessel blockage stroke …

This study looks at whether people with giant cell arteritis (GCA) who are in remission can safely stop or lower their dose of tocilizumab (Actemra). About 78 adults who have been on high-dose tocilizumab for at least a year and off steroids for three months will either stop the …

This study compares two treatments for small ischemic strokes (lacunar strokes): a combination of antiplatelet drugs (pills) versus the standard clot-busting drug tPA given through an IV. The goal is to see if the pill combo works just as well but causes fewer bleeding problems. …

This study tests whether adding mental imagery training to robotic hand exercises improves arm and hand function in people who had a stroke at least 6 months ago. Forty participants will receive either robotic hand training alone or combined with mental imagery over 7 weeks. The …

This study is testing a new device called the Choydar flow-directed mesh stent for people with unruptured brain aneurysms—weak spots in blood vessels that could burst. The stent is placed inside the artery to block blood flow into the aneurysm, helping it heal. Researchers will f…

This study tests a new device that uses brain signals to time magnetic pulses for stroke rehabilitation. The device reads blood flow changes in the brain and fires a magnetic pulse at the right moment to boost brain activity. Researchers will first test the system in healthy adul…

This study tests a new medicine, EYP-1901, given as an eye injection to people with diabetic macular edema (DME), a condition that causes blurry vision in people with diabetes. The goal is to see if EYP-1901 works as well as the standard treatment (aflibercept) but with fewer inj…

This study tests whether a robotic hand device can help people recovering from a stroke improve hand strength and dexterity better than standard physical therapy. Thirty adults with sub-acute stroke (2 weeks to 6 months post-stroke) will be randomly assigned to receive either rob…

This phase 3 trial tests EYP-1901, a new eye injection, against the standard treatment aflibercept for diabetic macular edema (DME), a condition that causes vision loss in people with diabetes. The study will enroll 240 participants and compare how well each drug improves vision …

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This study tests a new drug called TS23, an antibody that may help people recover from ischemic strokes by lowering the chance of bleeding in the brain. The trial involves 300 adults who have had a stroke and will receive either the drug or a placebo. Researchers will check for b…

This trial tests a special cannula that captures debris during high-risk heart valve surgery. The goal is to see if it reduces the chance of stroke, kidney injury, and delirium. About 842 patients aged 60 and older will be randomly assigned to receive either the new device or a s…

This study tests whether Diroximel Fumarate, a drug already used for multiple sclerosis, can reduce harmful brain swelling that often occurs after a hemorrhagic stroke. The swelling, called perihematomal edema, can worsen recovery. The trial will enroll 192 adults who have had a …

This study tests whether robot-assisted foot and ankle training, combined with virtual reality, can help people with chronic stroke walk faster and improve balance. Thirty participants will either receive this robotic therapy or standard manual training, plus usual rehab, for 6 w…

This study is tracking how well a device called NeVa VS works to open narrowed brain arteries in people who had a bleeding aneurysm. The device is already approved for this use, and researchers want to see how it performs in routine care. About 200 adults will be followed to meas…

This study tests whether the antibiotic minocycline can improve recovery in people who have had a major stroke and undergone a procedure to remove a blood clot from a large brain artery. Even when the clot is successfully removed, many patients still have significant disability. …

This study tests whether combining a brain-computer interface training with audio cues played during sleep can improve arm function in people who had a stroke at least 6 months ago. 70 participants will practice moving a cursor on a screen using muscle signals, then hear related …

This study tests whether adding the antibiotic minocycline to standard stroke treatment can improve recovery in people who had a severe stroke in the back of the brain. After a clot is removed, brain inflammation can limit healing. Minocycline may reduce that inflammation. The tr…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study tests whether a structured care bundle—including rapid blood pressure control, reversal of blood thinners, and management of fever and blood sugar—can improve outcomes for people with a brain bleed. About 3500 adults in Sweden and Australia will receive either the care…

This study tests whether low-intensity focused ultrasound (tFUS) can help people with severe traumatic brain injury who have not fully recovered consciousness. Researchers will compare real tFUS to a sham (fake) treatment in 60 participants, measuring changes in consciousness usi…

This study tests whether placing a stent in the brain artery after removing a clot can improve recovery for people having a severe stroke. About 342 adults aged 18-80 with a blocked large artery and significant residual narrowing will be randomly assigned to get either standard c…

This Phase 2 trial tests whether a new drug called MEDI0618 can safely reduce the number of migraine headache days in adults with episodic migraine. About 488 participants will receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug lowe…

This study tests a tool called Savvy, which includes phone exercises, a weekly pill organizer, and text reminders, to help stroke survivors take their blood pressure medication as prescribed. Researchers will compare medication adherence and blood pressure control between those u…

This study tests a brain implant that records activity from the motor cortex and stimulates the sensory cortex. It aims to help people with severe arm or hand impairment—due to spinal cord injury, stroke, or amputation—control external devices like computers. The trial focuses on…

This study tests whether giving patients electrical muscle stimulation and high-protein shakes soon after a type of stroke (aneurysmal subarachnoid hemorrhage) can prevent muscle loss and improve recovery. Thirty adults will receive the combo therapy or standard care. The main go…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This early-stage study tests whether a drug called anisodine hydrobromide is safe for people having a stroke caused by a blocked large artery in the brain. About 92 adults aged 18 to 80 who are already scheduled for a clot-removal procedure will receive the drug. The main goal is…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly ass…

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests whether a procedure called hemoadsorption, which filters the blood, can help people with severe ischemic stroke. Researchers will compare standard care plus hemoadsorption to standard care alone in 116 adults. The goal is to see if the procedure reduces the chanc…

This study tests a new drug called BB-031 in people who have had a stroke within the last 24 hours. About 228 participants will receive either the drug or a placebo, and researchers will check for safety, side effects, and how the drug works in the body over 90 days. The main goa…

This study compares two treatments for early proliferative diabetic retinopathy, a complication of diabetes that causes abnormal blood vessels in the eye. One group gets early microincision vitrectomy surgery plus laser, while the other gets standard laser therapy alone. The goal…

This study looks at whether a 15-week lifestyle program combining weight management and exercise can improve walking and daily function in obese veterans who had a stroke at least six months ago. Researchers will measure changes in walking distance, daily steps, and overall recov…

This study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests a new decision-making tool called IMPROVE that uses MRI scans to detect unstable plaques in the carotid artery. The goal is to see if this method is at least as good as the current standard (which mainly looks at how narrow the artery is) for selecting which pati…

This study is testing a drug called Mexidol in people who have had an ischemic stroke (a stroke caused by a blocked blood vessel in the brain). The goal is to see if Mexidol can reduce the size of the brain injury and improve recovery. The trial will involve 120 adults aged 18 to…

This study tests whether a mild brain stimulation technique called tDCS, combined with treadmill training, can improve walking in people who have had a stroke. Researchers will enroll 100 adults who are at least 3 months past their first stroke and have trouble walking. The goal …

This study tests an experimental drug called QD202 in people who have had an acute ischemic stroke and received clot-busting medication. The drug is designed to cross into the brain and protect nerve cells. About 120 participants will receive either QD202 or a placebo daily for 5…

This study looks at a new way to treat severe brain bleeds caused by aneurysms. Instead of coiling the whole aneurysm, doctors will only coil the dome (the bulging part). The goal is to see if this lowers the risk of re-bleeding and improves recovery. The study will enroll 30 adu…

This study is testing whether using a blood test to guide antiplatelet therapy can better prevent recurrent strokes in people who have had a mild stroke or transient ischemic attack (TIA). About 5,100 participants will be assigned to either standard clopidogrel or ticagrelor base…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study looks at how long people at high risk of bleeding should take two blood thinners after having a carotid artery stent placed. About 1,556 participants will first take both aspirin and clopidogrel for 30 days, then be split into two groups: one continues both drugs for 1…

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study compares two medicines—apixaban (a blood thinner) and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents future strokes or death. About 700 pa…

This study is testing a device that sends mild electrical pulses to the vagus nerve in the neck, paired with physical therapy, to help people who had a stroke months or years ago. The goal is to see if this approach can safely improve arm and leg movement. About 40 adults with ch…

This study tests whether using an AI-driven retinal camera during regular diabetes checkups can increase the number of young people screened for diabetic retinopathy, a leading cause of blindness. Researchers will enroll 500 youth with type 1, type 2, or cystic fibrosis-related d…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study tests a new device called nOCT that acts like a tiny camera on a flexible wire. It slides into brain blood vessels during standard aneurysm treatment to take detailed pictures of the vessel wall and any implanted coils or stents. The goal is to see if these images help…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study is testing a home-based eye-tracking system called AVIGA to see if it can detect when wet age-related macular degeneration (AMD) comes back. Sixty adults aged 50-99 who are being treated for wet AMD will use the AVIGA device at home, and its accuracy will be compared t…

This study tests a simple 10-question scale designed to help neurologists quickly identify migraine patients who could benefit from physiotherapy. Many migraine patients have neck problems that make their headaches worse, but neurologists often lack time or training to assess thi…

This study tests whether a quick, routine ultrasound measurement (called the resistance index) can accurately identify people with narrowed neck arteries who have normal brain blood flow response. If it works, many patients could avoid a time-consuming, specialized test. The stud…

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This Phase 2 study tests whether a daily pill called EVO756 can prevent migraines in adults who have not had success with other preventive treatments. About 330 participants will receive either EVO756 or a placebo, and researchers will track how many migraine days they have each …

This phase 3 trial tests whether injections of Xeomin (a botulinum toxin type A) into head and neck muscles can prevent episodic migraines. About 990 adults with episodic migraine will receive either Xeomin or a placebo every 12 weeks for up to 55 weeks. The main goal is to see i…

This study looks at the safety and effectiveness of atogepant, a drug already approved for migraine prevention, in Korean adults. About 3000 people with chronic or episodic migraines will take the drug as prescribed by their doctor and be followed for up to 12 weeks. The goal is …

This phase 3 trial tests whether two different eye treatments can prevent vision loss in people who have had radiation therapy for a type of eye cancer called uveal melanoma. The study will compare faricimab injections given every 3 months, a fluocinolone acetonide implant placed…

This study tests an investigational drug called OHB-607 to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature infants. About 338 babies will be randomly assigned to receive either the drug or standard care. The goal is t…

This trial tests whether a community-based screening program using advanced eye imaging (OCT, fundus photography, and pressure checks) can prevent vision loss from age-related macular degeneration, diabetic retinopathy, and glaucoma better than simple vision tests alone. About 60…

This study tests whether the medicine rimegepant can prevent migraines in teenagers aged 12 to 17 who have frequent, long-lasting headaches. About 200 teens will take either rimegepant or a placebo every other day for 3 months, then all will receive rimegepant for a year. The goa…

This study tests a special therapy for stroke patients in the hospital to help them avoid falls after they go home. Falls are common after a stroke and can cause injuries or fear of falling. The therapy includes extra exercises and education about fall risks. Researchers will tra…

This study tests whether giving HIV prevention pills (PrEP) to people right in the emergency room helps them start and stay on prevention. Researchers will enroll 250 HIV-negative adults at risk for HIV in Dallas. Participants get a 30-day pill supply and a clinic appointment to …

This study tests an online program called UPDOs Protective Styles to help Black women in the southeastern US learn about and start using PrEP, a medicine that prevents HIV. Researchers will recruit 1000 participants from 32 beauty salons in areas with high HIV rates. One group wi…

This study looks at whether patients and doctors in a family planning clinic find it acceptable to discuss and start PrEP, a daily pill that prevents HIV. About 83 English- or Spanish-speaking patients aged 16 and older, along with their doctors, will take part. Patients will rec…

This study tests whether using a carotid ultrasound (a neck scan) to find hidden plaque in arteries can help prevent heart attacks and strokes in people with inflammatory rheumatic diseases like rheumatoid arthritis or lupus. About 1,944 participants aged 50 and older will be spl…

This study tests whether adding music-like sounds (sonification) to standard walking rehabilitation can improve gait, balance, and quality of life. 120 adults with Parkinson's disease, stroke, or multiple sclerosis will be randomly assigned to standard rehab or rehab with sonific…

This study tests whether a home-based telerehabilitation program, using games, exercises, and video calls with therapists, can improve arm function and reduce disability in people who had a stroke 90-150 days ago. 202 participants will be randomly assigned to receive telerehabili…

This study tests a wearable device that sends gentle, low-frequency electromagnetic fields to the brain to help people who had a stroke more than 6 months ago recover arm movement and reduce disability. About 25 adults with chronic stroke will use the device in a clinic to see if…

This phase 2 trial tests whether injecting lidocaine and methylprednisolone into the middle meningeal artery can reduce severe headaches after a subarachnoid hemorrhage (a type of brain bleed). The procedure is done during a routine angiogram and aims to lower pain and opioid use…

This study tests a new drug, elismetrep, to see if it can quickly stop migraine pain and bothersome symptoms like nausea or light sensitivity. About 1800 adults with frequent migraines will receive either the drug or a placebo. The main goal is to measure how many people are pain…

This study tests the long-term safety of rimegepant, a migraine medication taken as a dissolving tablet, in children and adolescents aged 6 to 18. About 600 participants with a history of migraine will take the drug as needed for up to one year. The main goal is to check for side…

This study looks at whether taking a second dose of the migraine medication rimegepant is safe and helpful for adults whose migraine pain isn't fully relieved by the first dose. About 400 people aged 18 and older with a history of migraines will take part. Researchers will track …

This study tests whether rimegepant, a fast-dissolving tablet, can safely relieve migraine pain in children and adolescents aged 6 to 18. About 2,100 participants will receive either the drug or a placebo during a migraine attack. The main goal is to see if more kids become pain-…

This study tests a wearable neuroprosthesis that uses mild electrical stimulation to help stroke survivors open their hand. Two participants will use the device at home for one year to see if it improves daily activities and quality of life. The goal is to understand how well the…

This study tests whether doing yoga-based exercises once a week for 8-12 weeks can reduce headache frequency and improve sleep and quality of life in people with chronic migraine or cluster headache. Participants can join online or in person. The goal is to see if yoga can be a h…

This pilot study will test whether chiropractic care can help people with episodic migraine (4-13 migraine days per month). Sixty adults aged 18-65 will receive either personalized chiropractic care or headache health education. The main goal is to see if a larger trial is feasib…

This pilot study tests whether a structured, evidence-based physical therapy program (including education, aerobic exercise, and relaxation) works better than standard physiotherapy for adults with migraine. About 195 participants aged 18-70 with a confirmed migraine diagnosis wi…

This study tests a wearable robotic knee device (AKO-R) to help people who have had a stroke walk more symmetrically. Twenty participants will do treadmill and overground walking with the device. Researchers will check safety and measure improvements in step length and stance tim…

This study compares two types of speech therapy for people with aphasia, a language disorder often caused by stroke. One therapy, called Semantic Feature Analysis (SFA), helps people name objects by describing their features. The other adds metacognitive strategy training (SFA+MS…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can improve heart rate variability and quality of life in people who have had a stroke. 44 participants will receive either real or sham rTMS for 4 weeks. The goal is to see if this brain stimulation can…

This study tests whether adding immersive virtual reality (VR) to robotic walking rehabilitation is tolerable for people who cannot walk after a stroke. Thirty non-walking stroke patients will try both standard robotic rehab and VR-enhanced sessions. Researchers will measure moti…

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study is testing whether combining two types of electrical stimulation with a robotic arm trainer can help people who had a stroke at least six months ago improve their arm movement. 65 participants will receive 20 sessions over 4-7 weeks. The goal is to see if this approach…

This study compares a home-based telerehabilitation program (Tele-CPASS) to standard in-person therapy for improving arm and hand function after a stroke. Forty-two recent stroke survivors with arm weakness will be randomly assigned to receive 20 hours of either remote or in-pers…

This study tracks about 1,000 people with migraine who are taking AJOVY (fremanezumab) as part of their regular care. The goal is to see how safe the drug is over the long term, especially regarding heart problems. Researchers will also collect information on how well it works. T…

This study tests whether a spinal cord stimulator, combined with physical therapy, can help people who have had a stroke regain arm and hand movement. Twenty adults with long-term arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimulat…

This study tests whether a combination of two existing drugs, nortriptyline and topiramate, can reduce vertigo and other symptoms in people with Meniere's disease. Forty adults with active Meniere's will take the drugs or a placebo for 8 weeks. The goal is to see if this approach…

This study tests whether a gentle, non-invasive nerve stimulation (called tVNS) applied to the ear or neck can improve arm movement, thinking, and quality of life when paired with standard therapy in people who had a stroke 3–6 months ago. About 54 adults who had their first isch…

This study tests a wearable device that vibrates leg muscles to reduce spasticity (stiffness) and improve walking. Twenty-five people with spasticity from a neurological condition will use the device for 15–60 minutes in the lab and at home. Researchers will measure muscle activi…

This study tests whether a non-invasive brain stimulation technique called TMS, combined with language therapy, can improve speech in people who have aphasia after a stroke. Researchers will compare real TMS to a sham (fake) version in 63 participants who had a stroke 2 to 6 week…

This study tests two pain-relief methods—low-dose laser and TENS—for people with moderate to severe shoulder pain after a stroke. About 45 adults who had a stroke within the last 2 weeks to 6 months will receive one of the treatments. The goal is to see which works better for pai…

This study looks at whether adding a modified form of cognitive behavioral therapy (a type of talk therapy) to standard occupational or speech therapy can improve emotional well-being and daily functioning in stroke survivors. The trial will enroll 80 adults who had a stroke at l…

This study tests whether using a soft robotic hand together with electrical stimulation can help stroke survivors regain hand movement faster than using either therapy alone. About 64 adults who had a stroke 3-6 months ago will receive 40-minute sessions three times a week for 8 …

This study looks at whether a regular exercise program can improve the benefits of botulinum toxin (Botox) injections for arm stiffness after a stroke. About 70 stroke survivors with arm spasticity will receive Botox and then be randomly assigned to either a prescribed exercise r…

This study tests whether a new type of virtual reality therapy can improve arm function in people who had a stroke. Fifty-four participants will try different versions of mirror therapy, some with added attention-focusing techniques. The goal is to see which approach works best f…

This study tests whether using a higher voltage during a nerve-blocking procedure (pulsed radiofrequency) can better relieve pain in people with chronic migraine who haven't responded to at least two preventive medications. One hundred participants will be randomly assigned to re…

This study is testing a nurse-led mind-body program to help children and teens with migraine have fewer headache days. The program combines different treatment parts, like relaxation and coping skills, to find the best mix. The study will include 260 participants aged 10-17 who h…

This study tests whether a higher-than-usual dose of the seizure medicine levetiracetam can safely stop seizures in newborns. About 133 full-term infants with seizures will first receive a standard dose, and if seizures continue, they will be randomly assigned to get either a hig…

This study looks at urinary problems in people recovering from a stroke. Researchers compare patients with and without bladder issues and test two simple behavioral approaches: for those with thinking difficulties, training to go to the toilet immediately when they feel the urge;…

This study tests whether adding telerehabilitation (home-based, supervised and independent arm exercises) to usual care improves arm function and reduces disability after a stroke. Twenty adults in Brazil who had a stroke about 4 months ago will participate. The goal is to see if…

This study tests a mixed-reality system called RehAtt to help people recover movement after a stroke. Ten participants with one-sided weakness will use the system for arm, walking, and balance exercises. Researchers will interview them to see if the system is easy, motivating, an…

This study is testing a digital care program for adults with migraine. The program includes a wearable device that uses nerve stimulation, personalized exercises, and support from a care team. The goal is to see if it can reduce the number of migraine days per month. About 140 pe…

This study tests whether numbing certain scalp nerves can stop migraine pain quickly and prevent future attacks. Researchers will compare blocking two nerves versus ten nerves in 60 people who have frequent migraines. The goal is to see if this approach can eliminate headache pai…

This study tests an investigational inhaled medication called ASY202 (dihydroergotamine dry powder) for treating migraine attacks in adults. Participants use a handheld inhaler to take the drug or a placebo during separate migraine episodes, and neither they nor the study team kn…

This study tests whether combining low-intensity resistance training with blood flow restriction therapy can improve arm strength, reach, and sensation in people who have had a stroke. Researchers will enroll 64 adults aged 50–70 who are at least one month post-stroke. The goal i…

This study tests whether a twice-weekly exercise program can improve sleep quality in people who had a stroke at least a year ago and currently have poor sleep. 62 participants aged 55 and older will take part in 60-minute classes over 6 months. The goal is to see if exercise can…

This study tests whether lower limb sensorimotor training (exercises that improve touch and movement awareness) or whole-body vibration therapy (standing on a vibrating platform) can help stroke survivors aged 50-65 improve their balance and reduce fear of falling. Fifty-two part…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests whether a special needle treatment guided by ultrasound can help people who had a stroke walk faster and move better. Thirty adults who can already walk 10 meters will either get regular physiotherapy alone or physiotherapy plus this nerve stimulation. Researcher…

This study tests if pairing a gentle, non-invasive brain stimulation (tDCS) with personalized physical therapy can help people with cerebellar damage (from stroke, tumor, or degeneration) improve movement and daily function. About 30 adults aged 18-75 will participate. The goal i…

This study tests whether adding a wearable vibratory device to standard physiotherapy helps improve arm function in people with hemiplegia (paralysis on one side) after a stroke. Thirty adults who had a stroke 3 to 6 months ago will be split into two groups: one gets usual therap…

This study tests whether combining a non-invasive brain stimulation technique (rTMS) with machine-assisted hand exercises can help stroke survivors regain arm and hand movement. Researchers will enroll 54 adults aged 40-80 who had a first stroke within the past year. Participants…

This study tests whether vagus nerve stimulation (VNS) paired with rehabilitation can improve leg and walking function in people who have had an ischemic stroke. Researchers will enroll 24 adults who are already approved for VNS therapy for arm problems. The goal is to see if thi…

This study compares two non-drug, virtual programs for adults with migraine. Both involve 8 weekly group sessions and online learning. Researchers want to see if these programs can reduce migraine-related disability and improve mood. Participants can continue their usual medicati…

This study tests whether adding motor imagery—mentally rehearsing movements without actually moving—to standard physical therapy can improve arm function in stroke survivors. About 51 adults who had a stroke at least 3 months ago will be split into three groups: standard rehab al…

This study tests a training method called MINT that helps stroke survivors reduce abnormal muscle co-activation in their legs. The goal is to improve walking speed and endurance. Researchers will enroll 72 adults who had a stroke at least 6 months ago and have moderate to severe …

This study tests a therapy where chronic stroke patients watch videos of hand and arm activities, then practice those movements. Researchers want to see if watching one-handed or two-handed actions works better for improving arm function, daily living skills, and quality of life.…

This study tests whether watching and copying hand movements during video calls can improve arm function, daily activities, and quality of life in people who had a stroke at least 6 months ago. Thirty participants will be assigned to either this video-based therapy or standard in…

This study compares two types of exercise programs—pelvic proprioceptive neuromuscular facilitation and multiplanar trunk training—to see which one better improves balance and functional mobility in people who have had a stroke. The trial will involve 48 chronic stroke survivors …

This pilot study from Mayo Clinic tests whether a virtual lifestyle behavior training program can help people with chronic migraine have fewer attacks. Sixty adults with chronic migraine for at least one year will be randomly assigned to either the lifestyle program or a sham edu…

This study tests whether a one-time high-dose intravenous ketamine infusion can reduce the number and intensity of headaches in people with chronic daily headaches. About 56 adults will receive either ketamine or a placebo (saline) and be followed for three months. The goal is to…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests a low-intensity brain stimulation method called kTMP to help people who had a stroke at least 12 months ago improve arm and hand movement. About 12 adults aged 18-80 with moderate arm weakness will receive kTMP alongside motor rehabilitation. The goal is to see i…

This small study tests whether electrical stimulation of the spinal cord can improve arm and leg movement in people who had a stroke at least 6 months ago. Only 6 participants with limited recovery will receive the treatment. The goal is to see if it is safe and helps with daily …

This study tests an oral medication called ubrogepant, already approved for adults, to see if it safely and effectively treats migraine attacks in children and adolescents aged 6 to 17. About 1,059 participants with a history of migraine will receive either a low or high dose of …

This study tests whether combining brain stimulation (rTMS) with a brain-computer interface can help people who had a stroke more than 6 months ago regain arm movement. The brain-computer interface translates thoughts of moving into electrical muscle stimulation. The trial will e…

This study tests whether a special swallowing exercise using a pressure-measuring ball can help older stroke patients with swallowing problems. Participants will do the exercises at home twice daily for 12 weeks. The goal is to see if it improves swallowing function and quality o…

This study tests whether home-based telerehabilitation can help stroke survivors who did not get outpatient rehab improve arm and hand function. Two hundred participants across Alberta will use the Tenzr system, which includes fun, game-like exercises with wearable sensors guided…

This study tests whether adding a gentle electrical current to the brain (tDCS) during intensive arm therapy helps women recover arm movement after a stroke. Twenty-four women will receive either real or fake stimulation over two weeks. The goal is to see if the combo improves ar…

This early study tests a device that uses your own breathing to trigger mild electrical stimulation, aiming to reduce hand stiffness and improve hand movement in people who had a stroke at least 6 months ago. Only 4 participants with moderate hand tightness will be enrolled. The …

This pilot study tests a device called BreEStim that uses breathing to control electrical stimulation of hand muscles. Four people who had a stroke at least 6 months ago and have moderate hand tightness will try one session. The goal is to see if it reduces finger stiffness and i…

This study tests a home grip assistance glove (SaeboGlove) to help stroke survivors use their weaker arm in everyday tasks. About 100 adults who had a stroke more than three months ago and have trouble opening their hand will try the glove at home. Researchers will compare how we…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This study tests a gentle, non-invasive brain stimulation technique called tACS to see if it can improve hand and arm movement in people who have had a stroke. Researchers will enroll 14 adults who are at least 6 months past their stroke and have some finger movement. The goal is…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study compares two physical therapy approaches—rhythmic guided movements and static muscle contractions—to see which better improves arm function, strength, and coordination in people who had a stroke 1 to 6 months ago. Forty participants aged 40 to 60 with arm weakness on o…

This early study tests a device called BreEStim, which uses breathing to control mild electrical stimulation, to see if it can reduce finger stiffness and improve hand function in people who had a stroke at least 6 months ago. Only 4 participants will receive a single 10-20 minut…

This study tests whether a home-based virtual reality (VR) neurofeedback program is practical and helpful for adolescents aged 10-16 with migraine. Participants use a wearable EEG headband that reads brain activity and guides the VR experience during short sessions three times a …

This study tests whether a safe, mild electrical current applied to the scalp (tDCS) can make speech therapy work better for people who have trouble speaking after a stroke. 24 participants with apraxia of speech will receive both real and sham stimulation at different times to s…

This study tests whether a personalized brain-training therapy (neurofeedback) can improve arm movement in people who recently had a stroke. About 44 participants will either receive standard or personalized neurofeedback during 15 sessions over three weeks. The goal is to see if…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve word-finding in people who have trouble speaking after a stroke. Researchers will use MRI scans to guide the stimulation and see how the brain responds. The trial involves 45 participants …

This study looks at whether a hands-on ankle manipulation technique can improve ankle proprioception (the sense of joint position) in people who have had a stroke. Researchers will compare the manipulation to a placebo in 26 stroke survivors, measuring ankle position sense and ra…

This study looks at whether special pelvic stability exercises can improve leg function in people who had a stroke within the past few months. Thirty-four participants will either get pelvic training plus standard leg therapy, or standard therapy alone, for eight weeks. Researche…

This study tests whether a numbing nasal spray can safely reduce severe headaches after a brain aneurysm bleed. About 20 adults in the ICU will receive the spray along with standard pain meds. Researchers will compare pain levels and opioid use before and after treatment to see i…

This study is testing whether a device that sends small electrical pulses to leg muscles can help people with chronic stroke improve their balance and walking. Twenty participants will be exposed to slip- and trip-like disturbances on a treadmill, with and without the stimulation…

This study tests whether combining mindfulness meditation with dual-task training (like walking while doing mental math) can improve thinking and physical skills in people with mild cognitive impairment after a stroke. Sixty participants will be randomly assigned to the combined …

This study tests whether a gentle electrical current applied to the brain can make speech therapy more effective for people with chronic aphasia (trouble speaking or understanding language) after a stroke. About 50 adults who had a stroke at least six months ago will receive eith…

This study tests if a lidocaine infusion into blood vessels in the skull can reduce chronic migraine pain, frequency, and duration. It involves 40 adults aged 18-75 with severe, hard-to-treat migraines. The treatment numbs pain receptors to provide relief.

This study tests whether arm therapy done online (telerehabilitation) works as well as the same therapy done in a clinic for people who had a stroke within the last 6 months. 28 participants will be split into two groups, each receiving Constraint-Induced Movement Therapy for 8 w…

This study tests whether basic body awareness therapy (gentle movement and mindfulness exercises) combined with lifestyle advice can reduce migraine attacks and improve daily life. Researchers will track pain, sleep, and quality of life in 40 adults who have at least 3 migraines …

This study tests two ways to help stroke patients safely remove their breathing tubes (tracheostomy). One method uses a speaking valve that allows talking, while the other gradually caps the tube. Researchers will compare success rates and safety in 120 patients across multiple h…

This study tests a new robot system (HIWIN MRG-P110) designed to help chronic stroke survivors improve their walking. The robot uses foot pedals to guide leg movements and can adjust how much it helps versus how much the patient must do on their own. Researchers will enroll 60 pe…

This study tests whether Gou-Teng-San (GTS), a traditional herbal medicine, can help adults with episodic migraine. About 40 participants will be randomly assigned to receive GTS or a placebo. Researchers will measure if GTS reduces the number of migraine days per month and eases…

This study compares Swiss ball exercises versus kinesthetic training to see which better improves balance and mobility in people who had a stroke at least six months ago. Thirty-six participants aged 45-65 will do supervised exercises for 8 weeks. Balance and movement will be mea…

This study tests the safety of a new drug called IGT-303 in healthy volunteers and people with chronic kidney disease (CKD). About 94 participants will receive either the drug or a placebo, given as a shot under the skin or into a vein. Researchers will monitor for side effects t…

This study tests whether a home-based arm exercise program, called GRASP, can help stroke survivors improve movement and use of their affected arm. Participants will do exercises at home for one hour daily and attend group sessions three times a week. The goal is to see if this p…

This study is testing whether combining two types of electrical stimulation can help people who have had a stroke lift their toes while walking. Participants will receive mild electrical currents on their scalp and leg while doing walking exercises. The goal is to see if this com…

This study tests whether early training that combines thinking tasks with physical movement can help people recover cognitive and motor skills after a brain aneurysm bleed. The training is done 4-5 times a week for 30 minutes while in the hospital. Researchers will measure memory…

This study tests if a digital app called LEXURE can improve language skills in people who have trouble speaking after a stroke (aphasia). About 116 adults who had a stroke at least 3 months ago will either use the app or do workbook exercises. The goal is to see if the app helps …

This study tests whether a noninvasive brain stimulation technique, timed to the patient's own brain waves, can improve arm and hand movement after an ischemic stroke. Researchers will enroll 144 adults who had a stroke 1-14 days ago and have significant arm weakness. Participant…

This pilot study tests whether a hands-on therapy called Mobilization and Tactile Stimulation (MTS) can help stroke survivors who have unilateral neglect—a condition where they are unaware of one side of their body. Six adults who are at least 20 weeks post-stroke will receive MT…

This study tests whether combining mirror therapy with a soft robotic glove can improve hand function in people who have had a stroke and have weakness on one side. 104 participants will be randomly assigned to receive either standard rehab, mirror therapy alone, the robotic glov…

This study tests a 12-week dance program designed for stroke survivors who have weakness on one side of the body. The program combines movement improvisation and adaptive dance to help improve balance, mobility, confidence, and participation in daily and social activities. Resear…

This study tests whether a gentle, non-invasive electrical stimulation on the ear (called trans-auricular vagus nerve stimulation) can help people recover arm movement after a stroke. About 48 adults who had a stroke within the last 6 months will receive either real or fake stimu…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests a 6-week virtual program called PVI that helps young stroke survivors build personal resources through inclusive volunteering. Researchers want to see if it improves work ability, self-confidence, and emotional well-being. 160 participants aged 18-64 who had a st…

This early-phase trial tests whether a one-hour occupational therapy session—teaching strategies like better lighting, contrast, and organizational tools—can help people with age-related macular degeneration, diabetic retinopathy, or glaucoma manage their medications. Fifty parti…

This study tests a program that combines storytelling and practical skills training to help young adults (ages 18-64) who have had a stroke feel more connected and capable in their communities. Over six months, 208 participants will attend eight one-on-one sessions with a facilit…

This study looks at whether the antidepressant vortioxetine can help people who suffer from both depression and migraine. Researchers will track 31 adults over 12 weeks to see if their mood and headache symptoms improve. The goal is to find a treatment that works for both conditi…

This study tests a training program for stroke survivors who have trouble paying attention to one side of their world, a condition called spatial neglect. The training teaches mental strategies to improve awareness and daily functioning. Researchers will enroll 45 people living i…

This small pilot study tests whether a drug called cerebrolysin can help people who have been unconscious for over a month after a hemorrhagic stroke. Twelve adults aged 19 to 80 will receive either the drug or a placebo daily for two weeks. Researchers will measure changes in co…

This study tests a new shoe that makes a clicking sound when you walk, designed to help people with foot drop after a stroke. Foot drop makes it hard to lift the front part of your foot, causing tripping. The shoe gives audio feedback to help you walk more naturally. Fifty adults…

This study tests whether a powered exoskeleton can help stroke survivors walk with better balance. Twenty-one people who had a stroke at least six months ago will walk on a treadmill with and without the exoskeleton at different support levels. Researchers will measure how well t…

This study looks at whether a person's personality before a brain injury or stroke influences how well they recover thinking and memory skills. Researchers will follow 250 adults with severe acquired brain injury or stroke, testing their cognitive abilities, daily functioning, an…

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study investigates the sequence of early warning signs, called premonitory symptoms, that occur before a migraine headache starts. Researchers will follow 500 adults with migraine who will record their symptoms using an electronic diary for up to five attacks. The goal is to…

This study follows 5000 people admitted to a neuro-intensive care unit with life-threatening brain conditions like bleeding in the brain or severe seizures. Researchers collect medical data and biological samples to better understand how brain injuries progress and what factors h…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study aims to uncover genetic and environmental risk factors for hemorrhagic stroke, a type of stroke caused by bleeding in the brain. Researchers will analyze DNA, RNA, and blood samples from 1,000 adults who have had such a stroke, comparing them to healthy controls. By id…

This study looks at how stroke survivors with weakness on one side (hemiplegia) perceive internal body signals, like heartbeat, and whether that relates to their balance, touch sensation, and joint position sense. Researchers will assess 60 participants in a single session using …

This study is looking for ways to predict which migraine patients will respond well to a class of drugs called anti-CGRP monoclonal antibodies. Researchers will analyze clinical, biological, and brain imaging data from 350 adults with frequent migraines. The goal is to find bioma…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study explores whether migraine attacks can be predicted before the headache phase begins. Researchers will monitor people with episodic migraine (10–14 migraine days per month) using a wearable device that tracks heart rate and other body signals, along with a diary of earl…

This study looks at how well hospitals manage severe oxygen deprivation (asphyxia) in newborns at or near full term. Researchers will review care given during labor and after birth to find where improvements can be made. The goal is to help doctors and nurses provide better, fast…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study looks at MRI scans of 128 people who have had a brain hemorrhage (bleeding in the brain). Researchers want to see if a specific contrast pattern called a 'spot sign' can help predict which bleeds might get worse. By understanding these patterns, doctors hope to identif…

This study looks at whether keeping a patient's blood pressure within their personal safe range during heart surgery can reduce brain problems like confusion, stroke, or memory issues. Researchers will monitor 500 patients having heart surgery and track their blood pressure and b…

This study is creating a large collection of health information and biological samples (like blood, saliva, and eye tissue) from people with and without retinal diseases. Researchers aim to use this database to better understand conditions like age-related macular degeneration an…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This study follows 1,000 people with small, unruptured brain aneurysms (3-7 mm) for three years. Researchers will use MRI scans to see if a specific imaging sign—wall enhancement—can predict which aneurysms grow. The goal is to create a safer, personalized monitoring plan so that…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is translating and testing a French version of the Trunk Impairment Scale (TIS), a tool that measures trunk control and balance while sitting. Researchers will enroll 67 stroke patients to check if the scale is accurate and reliable. The goal is to give French-speaking…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This observational study collects data from UK preterm babies with retinopathy of prematurity (ROP) who are treated with the drug aflibercept (Eylea) using a paediatric dosing device. The main goal is to count how many babies receive this treatment and decide if there are enough …

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study will analyze health records from 2009 to 2024 to find out how many people in Germany have three serious eye conditions: wet age-related macular degeneration, diabetic macular edema, and retinal vein occlusion. Researchers will look at data from two large German health …

This study looks at how physical activity, sleep, and light exposure relate to mood in people with bipolar disorder, major depression, or no mood disorder. Over two years, participants wear activity monitors and complete smartphone diaries for up to 20 days at a time. The goal is…

This study aims to discover new genes that may cause certain cancers to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had cancer, especially childhood cancers. The goal is to build a regist…

This study investigates the specific cognitive strengths and weaknesses of children and adults with Sturge-Weber Syndrome (SWS), a rare condition affecting blood vessels in the brain, skin, and eyes. Participants complete a series of tests measuring memory, attention, language, a…

This study tracks how a touch signal on the finger travels through the nervous system to the brain. Researchers will apply different force levels to the finger and measure when people first feel it, along with brain activity using fMRI. The study includes 60 people: young adults,…

This study looks at whether people with migraine have different shoulder muscle activity and arm performance compared to those without migraine. Researchers will measure muscle signals and shoulder movement in 50 adults aged 18-55. The goal is to understand how migraine might aff…

This study uses a special eye scan (OCT angiography) to take detailed pictures of blood vessels in the back of the eye. Researchers will follow about 1,050 people with retinal diseases like diabetic retinopathy and healthy volunteers to see how these images can help detect early …

This study uses fMRI and EEG to understand how brain areas that plan movement interact with those that process sound during speech. Researchers will compare healthy adults and people who have had a cerebellar stroke. The goal is to learn how the brain adjusts hearing during speak…

This study explores whether exercising the unaffected leg at home can trigger beneficial brain and spinal changes in people with severe stroke. Participants perform strength and coordination tasks with their stronger leg using a tablet-based system, while researchers measure brai…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This study is a registry that will follow 1500 adults treated for acute ischemic stroke with Medtronic devices. Researchers will track safety, how well the devices restore blood flow, and whether patients regain independence after 90 days. The goal is to see how these devices wor…

This study looks at how taking a nap helps the brain remember new motor skills, like typing a sequence. Researchers will use brain scans to see what happens during rest and sleep. The study includes adults who have had a stroke and healthy volunteers of different ages. The goal i…

This study aims to find a blood marker that can tell how healthy the blood vessels in the eye are for people with diabetic retinopathy. Researchers will collect blood samples from 192 participants with type 2 diabetes and analyze special cells in the blood. The goal is to discove…

This study follows up to 4,000 people with vasculitis (a group of diseases that cause blood vessel inflammation) and healthy volunteers over many years. Researchers collect blood, urine, imaging, and genetic samples to learn how the disease develops and changes. The goal is to fi…

This study uses a brain imaging technique called fNIRS to watch how the brain changes during robot-assisted hand therapy in stroke survivors. Researchers will compare two types of robotic devices (end-effector and exoskeleton) to see which one better promotes brain reorganization…

This study tracks eye pressure in 100 people receiving a larger-volume injection of Aflibercept (0.07mL) for macular diseases like age-related macular degeneration. Researchers measure pressure right after the injection and at several time points, then check for any nerve damage …

This study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…

This registry is collecting data from 3,000 adults with atrial fibrillation who undergo a procedure to close off a part of the heart called the left atrial appendage. The goal is to track how well the procedure works to prevent strokes and to identify any complications. Hospitals…

This study tests how Tizanidine, a drug used for muscle stiffness, changes arm movement in people who have had a stroke. Researchers will measure brain activity, muscle responses, and movement patterns in 64 participants. The goal is to understand what limits movement after strok…

The CLUE study is a research project that follows 1,000 people with neuroinflammatory diseases like multiple sclerosis and neuromyelitis optica. Participants undergo detailed MRI and PET scans at the start and after one year to see how their brain, spinal cord, and optic nerves c…

This study is testing whether low-intensity focused ultrasound can help people with severe brain injuries who have not fully recovered consciousness. Researchers will measure changes in behavior and brain activity after ultrasound sessions. The study involves 36 participants and …

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study looks at whether a standard shoulder X-ray can detect bone loss in the weak arm of people who have had a stroke. Researchers will measure bone thickness on X-rays from 65 stroke survivors and compare those measurements to the gold-standard DXA bone density scan. If the…

This study tests a 12-month community program (SCIP) for older adults in rural Ecuador. It includes group activities, peer support, and home coaching to reduce loneliness. Researchers will measure changes in social isolation, heart health, memory, and mood in 500 people aged 60 a…

This study uses PET and MRI brain scans to compare the activity of two key brain chemicals—dopamine and acetylcholine—in 30 people who have had a stroke, half with apathy and half without. The goal is to better understand what causes apathy after a stroke, which could eventually …

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This observational study is looking at 250 people who have had a stroke or mini-stroke due to narrowing of arteries in the brain. Researchers want to see if a specific platelet protein (FcγRIIa) and blood flow patterns on MRI can help predict who will have another stroke within a…

This early-stage study tests a technique that uses electrical stimulation to help stroke survivors improve arm movement. The idea is to correct mismatched sensory signals between vision and body awareness, which can interfere with motor learning. Only 3 people with chronic stroke…

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study will look at 54,000 adults having surgery with general anesthesia to see how different oxygen levels affect their recovery. Patients will receive lower, intermediate, or higher oxygen during their operation. The goal is to find which oxygen level reduces the risk of or…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study checks if a new melt-in-the-mouth version of a migraine drug works the same as the approved tablet. It involves 36 healthy adults who will take both forms at different times. The goal is to see if the body absorbs the drug similarly, not to treat migraines.

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study is collecting information from 850 people with wet age-related macular degeneration or diabetic macular edema who are being treated with faricimab (VABYSMO) in routine clinical practice. Over two years, researchers will track vision changes, treatment schedules, and sa…

This study looks at whether being left-handed or right-handed affects how well people recover arm movement after a stroke. Researchers will follow 500 adults who had a recent stroke for 6 months, measuring arm function with standard tests. The goal is to see if left-handed people…

This study looks at how stroke changes the way the spinal cord handles sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some healthy). The goal is to better understand spinal …

This study uses a brain imaging technique called MEG to look at how the brain recovers after a minor stroke. Researchers will scan 40 stroke survivors and 15 healthy older adults at 1, 6, and 12 months after the stroke while they perform a naming task. The goal is to understand w…

This study is creating a large database of eye measurements from 3,000 people with inflammatory eye diseases like diabetic retinopathy and age-related macular degeneration. Researchers will use advanced imaging to collect detailed information from both the front and back of the e…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study looks at how stroke changes the way the brain handles walking while doing another task, like listening or navigating. Researchers will monitor brain activity in 50 stroke survivors as they walk on different paths and respond to sounds. The goal is to better understand …

This study is following 3000 people in China who have cerebral venous thrombosis, a rare type of blood clot in the brain. Researchers will collect blood and spinal fluid samples to learn more about the disease and find markers that could help with diagnosis. The goal is to better…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at why some people with chronic migraine don't get better with standard treatments. Researchers want to see if a person's level of suggestibility—how easily they respond to suggestions or expectations—might help predict who could benefit from placebo effects. The…

This registry is following 4,000 people who have been treated with Medtronic devices for brain aneurysms or ischemic stroke. Researchers are tracking how well the devices work in everyday medical practice, including how often aneurysms are fully closed and how many patients regai…

This study collects fluid and blood samples from 260 people with age-related macular degeneration, diabetic retinopathy, or retinal detachment, plus healthy controls. Researchers will analyze proteins in these samples to identify markers that could help diagnose or track these ey…

This study aims to validate new guidelines for placing surface EMG electrodes on the calf muscles of people who have had a stroke. Researchers will compare the new EPICA guidelines with standard SENIAM guidelines using ultrasound to see which placement gives more accurate muscle …

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study looks at the best way to treat a fluid pocket (pseudomeningocele) that can form under the scalp after brain surgery. It compares doing nothing active (just watching and caring for the wound) with doing a procedure like draining the fluid or another surgery. The goal is…

This study looks at whether levels of nitric oxide in spinal fluid can predict dangerous blood vessel spasms after a type of brain bleed called subarachnoid hemorrhage. Researchers will compare nitric oxide levels in 40 patients with and without this condition. The goal is to fin…

This study tests whether ultrasound scans and patient questionnaires can better track disease activity in people with giant cell arteritis, a condition that inflames arteries and can cause blindness. Researchers will follow 175 patients in remission for one year, using ultrasound…

This study is creating a large collection of medical data and biological samples from 1,100 people with brain aneurysms. The goal is to find better ways to predict which aneurysms are at risk of rupturing, which could lead to more personalized monitoring and treatment. Participan…

This study follows 180 adults with cerebral small vessel disease to see how their condition changes over time after a stroke. Researchers will use MRI scans and blood tests to track disease progression and look for links to thinking skills, daily function, and stroke recurrence. …

This study tests whether adding immersive virtual reality (VR) to standard physical therapy helps people who recently had a stroke regain arm movement and improve quality of life. Researchers will also look at blood markers and genes that might predict recovery. About 120 adults …

This study looks at whether getting people moving early after a stroke, with the help of a special ultrasound to check blood flow in the brain, leads to better recovery than standard care. About 1,300 adults who have had an ischemic stroke will take part. The goal is to see if th…

This study is testing a simple bedside tool called the Falls Decision Rule to help emergency doctors decide whether older adults (65+) need a brain scan after a fall. Researchers will check if the tool accurately identifies who has a serious brain bleed and who does not. The goal…

This study looks at 50 adults who had a stroke caused by a blocked middle brain artery and were treated with a clot-removal procedure called thrombectomy. Researchers will use special MRI scans to measure brain activity and metabolism in the damaged area. The goal is to find earl…

This study is looking at whether a blood test measuring DNA methylation can predict the risk of silent brain injury in elderly patients undergoing TAVR, a minimally invasive heart valve replacement. About 542 people over age 70 with severe aortic stenosis will have their DNA test…

This study follows preterm infants who were part of an earlier study to see if a new, portable eye imaging device can detect hidden signs of retinopathy of prematurity (ROP), a vision-threatening condition. Researchers will compare the new imaging to standard photos and track chi…

This study is creating a large database of health information from 743 adults with HIV/AIDS across Brazil. Researchers will look at how common chronic diseases like heart disease, kidney disease, and cancer are in this group. The goal is to gather data to help improve health poli…

This study is testing three different doses of a non-invasive brain stimulation technique called rTMS in 26 chronic stroke survivors with arm weakness. The goal is to see which dose best boosts brain signals to the hand muscles and improves motor learning. Participants will recei…

This study looks at how changing what stroke survivors see in virtual reality affects their hand movements. 15 chronic stroke survivors and 15 healthy people will do hand exercises in VR while their finger movements and muscle activity are recorded. The goal is to understand how …

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk o…

This study looks at whether the 'stickiness' or viscosity of the carotid artery wall differs between people with vascular dementia and those with Alzheimer's disease. Researchers will measure artery wall viscosity in 140 older adults using ultrasound and pressure sensors. The goa…

This observational study at Yale University will follow 150 people who have had an ischemic stroke to see how changes in blood pressure affect their recovery. Researchers will use brain scans and thinking tests to understand the connection. The goal is to find better ways to mana…

This study looks at how people who had a stroke more than 6 months ago learn a new walking pattern using distorted visual feedback. Researchers want to see if a short 5-minute exercise session helps them remember the new walking pattern a day later. 80 participants will be split …

This registry collects information from people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Participants share their symptoms, family history, and genetic test results online. The goal is to help researchers understand these rare diseases and …

This study looks at 179 adults with migraine who also have neck or lower back pain. Researchers want to understand if these pains share common causes, like changes in how the brain processes pain. Participants will answer questionnaires and undergo pain assessments. The goal is t…

This study looks at how migraine headaches relate to pain sensitivity, work stress, and muscle pain in people who work at desks. Researchers will compare 159 office workers with and without migraine to find connections that could lead to better workplace health. The goal is to un…

This study tests a digital lifestyle platform designed to support patients after they leave inpatient rehabilitation. It includes people with COPD, heart problems, fractures, or minor stroke. Participants use the platform for six months, receiving personalized recommendations and…

This study uses blood samples from over 1,100 people to create artificial clots in the lab, mimicking brain hemorrhages. Researchers test a modified clot-busting drug (rtPA) to find the best dose for different bleeding risks. The goal is to improve clot removal and guide future t…

This study looks at whether combining prism adaptation training with electrical stimulation can help people who have had a stroke and have spatial neglect (trouble noticing things on one side). Researchers will measure changes in pointing behavior, brain activity, and walking abi…

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This study aims to understand how the information given to patients about their treatment affects their response to migraine medication. Researchers will give 60 adults with chronic migraine four different treatment conditions in a random order and measure changes in headache int…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study aims to find early warning signs for major chronic diseases like stroke, heart disease, and cancer by following 4,500 healthy adults aged 30-80 in Lishui. Participants will receive regular check-ups and long-term monitoring. The goal is to improve prevention and care a…

This study looks at how a newborn's brain and blood flow work together in the first minutes after birth. Researchers will place a small patch on the baby's scalp to measure brain activity and oxygen levels. The goal is to learn more about how babies adjust to life outside the wom…

This study is looking at how a protein called SNRK might be linked to aging of blood vessels. Researchers will take blood samples and use ultrasound to check artery stiffness in 180 adults aged 18 to 80. The goal is to find new ways to understand and possibly treat vascular aging…

This study aims to make brain aneurysm and AVM treatments safer and more effective by using computer models and artificial intelligence. Researchers will create detailed maps of each patient's brain blood vessels and simulate blood flow to help doctors plan procedures. The study …

This study looks at whether simple, non-invasive eye tests can help predict brain development in newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. Researchers will measure eye function using visual evoked potential (VEP) and ele…

This study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps diagnose st…

This study looks at 150 patients who are unresponsive after a brain bleed (intracerebral hemorrhage). Researchers use EEG to detect hidden brain activity when patients are asked to imagine moving. The goal is to see if this activity can predict who will regain consciousness and h…

Cerebral palsy (CP) is a brain injury that affects movement, but diagnosing it can take up to 2 years. This study follows 600 high-risk infants (premature, brain-injured, or with abnormal exams) across Irish hospitals. Researchers will use EEG sleep tests, protein markers, and co…

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This 10-year study will follow 500 Korean adults with CADASIL, a genetic brain disease that causes strokes and dementia. Researchers will track symptoms, brain scans, memory tests, and genetic information to understand how the disease progresses in Koreans. The goal is to improve…

This study aims to see if short videos featuring Latinx patients and doctors can encourage more Latinx people with diabetes to get regular eye exams. Researchers will survey about 1,500 people and hold small group discussions to measure changes in eye health knowledge and trust i…

This study looks at whether new, quick tests that measure how fast people can move can help doctors diagnose brain diseases like Alzheimer's and predict recovery after a stroke. Researchers will test 129 adults aged 40-85 with stroke or memory problems. The goal is to see if thes…

This study tests whether a 3D simulation software called Sim&Size can help doctors plan treatments for unruptured brain aneurysms more accurately than current 2D methods. About 576 adults will be randomly assigned to use the software or standard planning. Researchers will compare…

This pilot study tests whether a special wire can safely measure blood flow in the brain's smallest blood vessels right after a stroke clot is removed. The goal is to understand why some patients still have disability even when the main artery is reopened. Fifteen adults who had …

This study tests an 8-week online program that teaches stroke survivors how to start their own business. The goal is to help them find meaningful work and improve their confidence and life satisfaction. The program is for adults aged 18-65 who had a stroke and have been out of pa…

This study looks at sleep problems like sleep apnea and insomnia in 226 people who have had a stroke. Researchers want to see how these sleep issues affect recovery, daily activities, and quality of life. Participants will use a home sleep test and a smartwatch to track sleep and…

This study tests if combining a gentle brain stimulation technique (tDCS) with watching hand movement videos (action observation therapy) can help people who had a stroke regain hand function. 60 adults with chronic stroke will receive 10 sessions of either the combined treatment…

This study explores whether a special MRI technique can help people who have had a stroke improve their reading. Participants will practice controlling their own brain activity using real-time feedback from the MRI scanner. The goal is to retrain the brain's language areas to wor…