Neurovascular disorder

This trial tests whether transplanting neural stem cells directly into the brain can help people who have had a chronic ischemic stroke. The study involves adults aged 18-75 who had a stroke 6 to 60 months prior. Participants receive a single dose of stem cells, and the trial eva…

This trial tests whether high-dose vitamin D supplements can improve cognitive function in people who have had a stroke and developed thinking or memory problems. Participants will receive either vitamin D or a placebo for six months, and researchers will measure changes in cogni…

This study tests a device called the Surpass Evolve Flow Diverter, a small mesh tube placed inside an artery to redirect blood flow away from a brain aneurysm. The goal is to safely close the aneurysm and prevent it from rupturing. About 248 adults with unruptured, wide-neck aneu…

This study tests whether a structured exercise program done at home can improve walking ability and overall recovery in people who recently had a stroke. About 208 adults who had a stroke within the past two weeks will be assigned to either the home exercise program or usual care…

This study tests whether adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency stroke treatment helps people recover better after a severe stroke caused by a large blood clot in the front part of the brain. About 692 adults who are el…

This study tests whether the drug ubrogepant can prevent menstrual migraines when taken daily for a week around each period. About 496 women with regular cycles and a history of menstrual migraines will receive either ubrogepant or a placebo for three cycles, then all may receive…

This Phase I trial tests whether infusing specially trained immune cells, called TAA-T, can safely target and attack high-risk brain tumors in children and adults. The cells are made from the patient's own blood and are designed to recognize multiple tumor-related proteins, poten…

This study tests whether infusing a cold magnesium sulfate solution directly into the brain during emergency clot removal can improve outcomes for people with acute ischemic stroke. About 42 adults aged 18-80 with severe strokes will be randomly assigned to receive either standar…

This study tests a new approach called 'pill-in-pocket' anticoagulation for people with atrial fibrillation (AF), a heart rhythm condition that raises stroke risk. Instead of taking blood thinners every day, participants would stop them after a 30-day AF-free period and only rest…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This phase 2 study tests two drugs, sunitinib and temsirolimus, in 137 people with advanced rare tumors that have no cure. The goal is to see if these drugs can shrink tumors or slow their growth. Participants take one of the two drugs, and researchers measure how long the cancer…

This study follows 246 people who received the Pipeline Shield device to treat brain aneurysms. The device is a small mesh tube that blocks blood flow to the aneurysm, reducing rupture risk. Researchers are checking how well the aneurysm seals, whether the artery narrows, and if …

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This study is a long-term follow-up for people who previously received an injection of RGX-314, a gene therapy, for diabetic retinopathy (with or without diabetic macular edema). The purpose is to monitor the safety and effectiveness of the treatment over a total of five years af…

This study asks whether wearing a small heart monitor for two weeks at a time, twice, can better detect hidden irregular heartbeats (atrial fibrillation) in older adults who recently had a stroke or mini-stroke, compared to the usual 1-2 day monitoring. Atrial fibrillation is a m…

This study looks at whether semaglutide, a medicine for type 2 diabetes, can slow or prevent diabetic eye disease over 5 years. About 1500 adults with type 2 diabetes will receive either semaglutide or a placebo injection once a week, in addition to their usual diabetes medicatio…

This study tests a device called Amulet 2 that is implanted in the heart to seal off a small pouch (the left atrial appendage) where blood clots can form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners. About 4…

This study tests a new type of balance training for people who had a stroke within the past few weeks. The training uses controlled wobbles and shifts in the support surface to challenge patients' balance in a safe way, aiming to improve their ability to walk and perform daily ac…

This trial tests whether adding melatonin to the standard preventive drug propranolol can better reduce migraine attacks in children aged 5 to 15. Sixty children with moderate-to-severe migraine disability will receive either melatonin plus propranolol or propranolol alone for th…

This trial tests whether starting physical therapy early—while infants are still in the NICU and continuing until 12 months corrected age—can improve motor function and reduce the severity of motor delays in babies at high risk due to premature birth, brain injury, or other condi…

This study tests whether a focused, intensive stepping training program, called FIRST, can improve walking ability in people recovering from a recent stroke. Participants in inpatient rehabilitation receive physical therapy that prioritizes walking practice at higher cardiovascul…

This trial tests whether using optical coherence tomography (OCT) during a procedure to reopen a chronically blocked carotid artery is safe. The blockage can cause strokes, and doctors often need to see what's inside the artery after crossing the blockage. OCT provides high-resol…

This trial compares two common procedures—carotid endarterectomy (surgery to clean out the artery) and carotid stenting (placing a mesh tube to hold it open)—in people who have recently had an ischemic stroke caused by a blocked carotid artery. The goal is to see which approach l…

This trial tests whether a gentle electrical current applied to the brain — called transcranial direct current stimulation (tDCS) — can help older adults recover the ability to swallow after a stroke. Hospitalized patients aged 60 to 80 with swallowing difficulties will receive e…

This trial tests two rehabilitation techniques — synergy-based electrical stimulation and task-oriented training — to see which better improves leg movement and mobility in people who had a stroke 1 to 6 months ago. Participants, aged 40 to 60, will receive one of the two approac…

This study looks at people with idiopathic intracranial hypertension (IIH), a condition where high pressure inside the skull can damage vision. Researchers will track which patients need a surgical shunt to relieve pressure versus those who improve with weight loss and medication…

This study tests an experimental drug, NPI-001 (AT-001), in people with hereditary cystatin C amyloid angiopathy (HCCAA), a rare genetic condition that causes repeated brain bleeding and stroke. The trial includes about 15 participants aged 12 and older who carry the specific L68…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This study tests whether the drug deferiprone can safely lower iron levels in the brain after a bleeding aneurysm. About 66 adults who had a ruptured aneurysm will receive either deferiprone or a placebo for 14 days. Researchers will measure iron in spinal fluid, brain MRI scans,…

This trial tests whether a dietary supplement called Tertinat, containing epigallocatechin-3-gallate, can reduce major heart problems in people with atherosclerosis who have recently had bypass or stent surgery. Over two years, participants take either the supplement or a placebo…

This study tests whether giving stroke patients real-time feedback on muscle activity—either through a visual display or sounds—can improve balance, walking, and daily independence when added to standard physical therapy. The trial enrolls adults aged 20-30 who have had a hemiple…

This study tests whether a procedure called spinal cord stimulation can reduce blood vessel spasms that often occur after a brain aneurysm rupture. Participants have already had standard treatment for their aneurysm and will receive either real or sham stimulation. The goal is to…

This study tests whether Dysport injections can prevent chronic migraines in adults. Chronic migraine means having at least 15 headache days per month, with 8 being migraines. Participants receive injections into head, neck, and shoulder muscles every 12 weeks for up to 60 weeks.…

This trial investigates whether combining neuromuscular electrical stimulation (NMES) with therapeutic ultrasound can help stroke patients who also have sarcopenia—a condition of low muscle mass and strength. Participants receive four weeks of daily therapy, and researchers measu…

This phase 3 study tests whether erenumab (Aimovig), a monthly injection already approved for adults, can prevent migraines in children aged 6 to 17 with episodic migraine. About 457 participants receive either the drug or a placebo for 3 months. The main goal is to see if the dr…

This study compares standard high-intensity gait training and gait training with electrical stimulation against a new approach that uses real-time feedback on how muscles work together (muscle synergies). The goal is to see if this biofeedback method helps people with chronic str…

This study tests a new way to control leg exoskeletons by reading muscle signals in real time. Researchers use high-density electrodes to capture nerve activity and predict a person's intended movement, then have the exoskeleton assist accordingly. The trial includes both healthy…

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK…

This study tests whether a gentle, targeted electrical stimulation to the brain (HD-tDCS) can safely improve how stroke survivors perceive vertical balance. Participants who have had a stroke affecting one side of the brain will receive either active or sham stimulation while per…

This trial tests a long-acting injection of leuprolide acetate in children with central precocious puberty, a condition where puberty starts too early. The goal is to suppress puberty-related hormones, slowing or stopping early development. The study includes children aged 4 to 9…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS), combined with paired associative stimulation (PAS), can improve arm and hand movement in people who have had a stroke. The trial includes 40 adults who experi…

This trial tests whether a special training that uses unexpected slips on a low-friction platform can help stroke survivors improve their balance and reduce falls. Participants will practice recovering from slips in a safe lab setting, and researchers will track whether these ski…

This trial investigates whether using a device to continuously measure pressure inside the brain's fluid-filled spaces can improve outcomes for people who have had a bleeding stroke from a ruptured aneurysm. About 372 adults with moderate to severe bleeding will be randomly assig…

This study tests a new non-invasive brain stimulation device called kTMP (kilohertz transcranial magnetic perturbation) to see if it can help improve arm and hand movement in people who have had a stroke. The trial involves 7 adults aged 18-80 who had a stroke at least 12 months …

This study tests an investigational drug called HRS-7450 in 208 people who have had an acute ischemic stroke within the past 4.5 to 24 hours. Participants receive either a low, intermediate, or high dose of the drug or a placebo. The goal is to see if the drug helps improve recov…

This study tests a new drug called EYE103 (Restoret) against an existing treatment, ranibizumab (Lucentis), for people with diabetic macular edema, a condition that causes vision loss in diabetes. About 984 participants will receive injections into the eye every 4 weeks for a yea…

This study tests whether giving a fructose (a type of sugar) injection soon after a stroke, along with standard clot-busting treatment, can improve brain recovery. About 46 adults who have a stroke within the last 4.5 hours will be randomly assigned to receive either fructose plu…

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This study tests a wireless device that stimulates the vagus nerve during rehabilitation exercises to help people who have had a stroke recover arm and hand function. The approach, called targeted plasticity therapy, aims to enhance the brain's ability to rewire itself. The trial…

This study planned to test whether giving a child their own stored umbilical cord blood is safe for treating perinatal arterial ischemic stroke. It was designed for children aged 6 weeks to 6 years with MRI-confirmed stroke. The trial was withdrawn before enrolling any participan…

This study tests a new coil device (Kaneka i-ED) in 50 people with wide-necked brain aneurysms. The coil is placed inside the aneurysm to block blood flow and prevent rupture. Researchers will check how well it works, how safe it is, and whether it saves money compared to standar…

This study tests a special balloon catheter coated with the drug paclitaxel to treat narrowed or re-narrowed brain arteries. The balloon is inflated inside the artery to open it and release the drug, which may help prevent the artery from closing again. The trial includes 281 adu…

This pilot study tests a new device called OsciPulse that rapidly compresses the calves to improve blood flow and reduce the risk of blood clots in people hospitalized after a stroke. About 40 adults with leg weakness will be randomly assigned to receive either OsciPulse or stand…

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether the drug farcimab (Vabysmo), given as an injection before and after eye surgery, can reduce bleeding complications in people with diabetes who have bleeding inside the eye. About 100 adults will receive either farcimab or a sham injection. The goal is to …

This early-stage study tests a new drug called EYE201, given as three eye injections over 12 weeks, to see if it is safe and can help reduce swelling in the back of the eye. It includes people with three different eye conditions that cause vision loss: branch retinal vein occlusi…

This study tests a new eye injection called IBI302 for people with diabetic macular edema, a condition that causes vision loss due to diabetes. About 150 adults aged 18-80 with type 1 or 2 diabetes and swelling in the center of the retina will receive either IBI302 or an active c…

This clinical trial tests a risk-adapted approach for young children with newly diagnosed brain tumors. The treatment starts with chemotherapy to delay radiation, giving the brain more time to develop. Then, radiation is carefully targeted to the tumor area to reduce side effects…

This study aimed to test a drug called BAC in people with Alzheimer's disease or vascular dementia. The goal was to see if it could improve thinking and memory, and to check for side effects. However, the trial was withdrawn before any participants were enrolled, so no results ar…

This study looks at whether adding targeted laser treatment to the standard ranibizumab injections can help people with macular edema (swelling) from a central retinal vein occlusion need fewer injections over time. About 88 adults with this condition will receive either injectio…

This study tests whether two biofeedback devices—a balance platform (Huber) and a smart treadmill (C-Mill)—can improve balance and reduce fall risk in 120 older adults (65+) with chronic cerebral ischemia. Participants will do 8 sessions of training, and researchers will compare …

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This phase 2 trial tests a procedure called transarterial chemoembolization (TACE) for people with uveal melanoma that has spread to the liver. Doctors inject a chemotherapy drug (carmustine) mixed with an oily contrast agent (Lipiodol) directly into the liver's blood supply, the…

This study looks at whether a procedure called endovascular treatment (EVT) can help people who have had a mild stroke caused by a blocked large artery in the brain. About 300 participants will either receive EVT plus standard medical care or standard care alone. The goal is to s…

This study aimed to see if removing additional small clots after the main blockage is cleared could help stroke patients recover better. It planned to compare standard care with extra mechanical or drug-based treatments. However, the trial was withdrawn and enrolled zero particip…

This Phase 3 trial compares two drugs—methotrexate and tocilizumab—for treating giant cell arteritis, a condition that causes inflammation in large arteries. Both drugs are given alongside a tapering course of prednisone. The goal is to see if methotrexate, a cheaper and easier-t…

This study tests if stem cells from umbilical cords can help people recover brain function after a stroke. It includes 40 adults who had a stroke and are now in the recovery phase. The treatment is given as an infusion, and researchers check if it improves daily living skills and…

This study tests whether a pre-filled syringe is as safe as the traditional vial when giving the medicine bevacizumab for certain eye diseases. About 120 people with wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion will receive inject…

This early-stage trial tests whether stem cells from donated umbilical cords are safe for people who recently had a stroke. Forty participants will receive three monthly infusions of the cells along with standard aspirin therapy. The study is currently on hold, and its main goal …

This study tests a blood-filtering device called DELP in people who have had a hemorrhagic stroke (bleeding in the brain). The filter removes fats and other substances from the blood to reduce brain swelling and damage. About 356 adults aged 18-80 with mild to moderate stroke sym…

This study compares two ways of giving faricimab, a drug injected into the eye, to treat diabetic macular edema (DME). One group gets injections on a fixed monthly schedule, while the other uses a 'treat and extend' approach where the time between injections is gradually lengthen…

This study looks at whether genetic testing can help doctors pick the right antiplatelet medicine for people who have had a stroke or mini-stroke. About 350 patients will be randomly assigned to either standard care or a genetic test that checks if a common drug, clopidogrel, is …

This study compares two ways to help stroke survivors control their blood pressure using telehealth. About 86 participants will receive either enhanced remote monitoring or standard care. The goal is to see which approach better helps people reach a safe blood pressure target and…

This pilot study tests whether a blend of in-person therapy and home-based digital rehab (video calls and apps) works as well as traditional full in-person rehab for people recovering from stroke, brain bleeding, or head injury. Thirty participants will each try both approaches i…

This was a very early (Phase 1) study that planned to give a mixture of cold saline, minocycline, and magnesium directly into the brain's arteries right after a stroke procedure to reopen blocked vessels. The goal was to see if this cocktail could safely protect brain tissue and …

This study tests whether levodopa, a drug used for Parkinson's, can slow blood vessel changes in the eyes of people with diabetes. Researchers will give the drug or a placebo to 244 patients with early diabetic retinopathy and measure retinal electrical activity and imaging over …

This study tests an experimental drug called MW189 in 120 adults who have had a brain bleed (intracerebral hemorrhage). The goal is to see if the drug is safe and can reduce brain swelling. Participants receive the drug within 24 hours of their stroke and are monitored for side e…

This study looked at 800 adults who had a stroke from a large blood clot in the brain. It compared a new device called the NeVa Stent Retriever to standard devices used to remove the clot. The goal was to see if the new device could restore blood flow better and with fewer side e…

This study tests a device called the Contour System to treat brain aneurysms (weak spots in blood vessels that can burst). The device is placed inside the aneurysm to block blood flow and prevent rupture. The trial involves 250 adults aged 18-75 with a specific type of aneurysm. …

This study follows 500 people who received the Surpass Evolve flow diverter, a device placed in brain arteries to treat aneurysms. Researchers will track safety and effectiveness for up to 5 years, focusing on stroke risk and aneurysm closure. The goal is to confirm the device wo…

This study tests whether repeatedly inflating a blood pressure cuff on the arm (called remote ischemic conditioning) can improve thinking and memory in people who have had a stroke or have small vessel brain disease. Eighty participants will receive the treatment twice daily for …

This study is testing a new device called the Citadel Embolization Device, a coil used to block blood flow in brain aneurysms. It involves 150 adults aged 18-80 with unruptured or recently ruptured wide-neck aneurysms. The goal is to see if the device safely and effectively seals…

This study follows 195 adults who received the WEB device, a mesh implant used to block blood flow into wide-neck brain aneurysms. Researchers are checking how well the device works and its safety over one year. The goal is to confirm that the device remains a reliable option for…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study is testing a device called FRED X, a small mesh tube placed inside an artery to block blood flow to a brain aneurysm. The goal is to see if it works as well as the earlier FRED device in preventing strokes and sealing the aneurysm. About 154 participants with a single …

This study tests whether adding spironolactone to standard blood pressure treatment helps lower blood pressure more effectively in people who have had a stroke. About 160 adults who had a bleeding or clot-caused stroke are taking spironolactone or continuing their usual care. Res…

This Phase 3 trial tests whether butylphthalide soft capsules can improve thinking, memory, and daily living skills in people with mild to moderate vascular dementia. About 707 participants are randomly assigned to receive either the drug or a placebo for 52 weeks. The study aims…

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This early study tests a new, experimental device called the HARBOR Occlusion Device for treating brain aneurysms. Ten adults with a single unruptured brain aneurysm will receive the device to see if it safely and effectively blocks blood flow to the aneurysm. The goal is to prev…

This study tests a higher dose (8mg) of aflibercept in 40 adults with proliferative diabetic retinopathy (PDR) who do not have swelling in the center of the retina. The goal is to see if this treatment can improve the severity of the disease and maintain vision over 96 weeks. Par…

This trial tests a nasal spray called MIG-SPRAY for preventing migraines in 45 adults aged 18-55. The spray forms a protective film inside the nose to possibly stop migraine triggers. Participants use it three times daily for three months, and researchers track side effects and m…

This early study tests whether beta-sitosterol, a plant-based supplement, can safely help people recover from a severe type of stroke called subarachnoid hemorrhage. Forty adults who have had this stroke will take the supplement for six months. The study will check for side effec…

This study looks at a device called the AMPLATZER PFO Occluder, which is implanted to close a hole in the heart (PFO) in people who have had a stroke. Over 1,200 participants are being followed for up to 5 years to see if the device prevents another stroke and is safe. The goal i…

This study is testing a device called the Pipeline™ Flex Embolization Device with Shield Technology™ to treat wide-necked brain aneurysms. The device is a small mesh tube that is placed inside the artery to divert blood flow away from the aneurysm, helping it heal. The study will…

This study planned to test whether adding the antibiotic minocycline to standard stroke treatment could improve recovery in people who had a severe stroke. It was designed as a small, early-phase trial with about 40 participants, but it was withdrawn before enrolling anyone. Beca…

This study tests whether galcanezumab, a monthly injection, can prevent chronic migraine in 312 adolescents aged 12 to 17. Participants receive either the drug or a placebo for 3 months. The main goal is to see if the drug reduces the number of migraine days per month.

This phase 2 trial tests whether high-dose chemotherapy followed by a stem cell transplant can stop the immune system from attacking the nervous system in people with autoimmune neurologic diseases like multiple sclerosis and stiff person syndrome. The treatment aims to weaken th…

This study follows 160 people who have or will get a CODMAN CERTAS Plus valve, a device implanted in the brain to drain extra fluid. The main goal is to see if the valve is placed correctly and works without problems 30 days after surgery. Participants include children and adults…

This early-phase trial tests a combination of umbilical cord stem cells (injected into the brain) and a liquid called conditioned medium (given as nose drops) in 15 people who recently had a stroke. The goal is to see if this approach is safe and can help the brain grow new cells…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This study is testing a new device called CLAAS that is implanted in the heart to close off a small pouch (the left atrial appendage) where blood clots often form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners…

This early-phase trial tests a single injection of a gene therapy called RTx-015 in 10 adults with retinitis pigmentosa or choroideremia, two inherited conditions that cause vision loss. The therapy delivers a gene that makes retinal cells produce a light-sensitive protein, poten…

This early-stage trial tests whether metformin, a common diabetes drug, is safe and feasible for infants who suffered brain injury from lack of oxygen at birth. Thirty infants under 6 months old will receive metformin for 6 weeks, with close monitoring of kidney and liver functio…

This study tests whether a newer type of blood thinner (DOA) works better than the standard one (VKA) for dissolving dangerous blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The goal is to see which drug redu…

This study compares two treatments for chronic migraine: a nerve block and a radiofrequency procedure. Researchers will measure blood levels of migraine-related proteins (CGRP and PACAP38) before and one month after treatment. The goal is to see which procedure works better and w…

This study tests if a device that closes a small pouch in the heart (left atrial appendage) is safer and more effective than long-term blood thinners for preventing strokes in people with atrial fibrillation. About 2,650 participants with AFib and high stroke risk are randomly as…

This early-stage trial is testing whether it is safe to inject a person's own bone marrow stem cells into their eye to treat vision loss from conditions like macular degeneration and diabetic retinopathy. Fifteen adults with severe vision loss will receive the injection and be mo…

This study looks at whether giving steroids early to children who had a stroke from a condition called focal cerebral arteriopathy (FCA) can help reduce damage to the brain's arteries. About 80 children aged 1 to 18 will be randomly assigned to get steroids right away or only if …

This study is tracking 500 Italian adults with migraine to see how well the daily pill atogepant works in everyday life. Researchers will measure changes in monthly migraine days over a year. The goal is to find out if atogepant is a safe and effective preventive treatment for pe…

This phase 3 trial tests whether a drug called recombinant factor VIIa (rFVIIa), given within 2 hours of a bleeding stroke, can limit brain damage and improve recovery. About 860 adults aged 18–80 with spontaneous intracerebral hemorrhage are enrolled. The study compares rFVIIa t…

This study tests whether regular exercise and cognitive training, alone or together, can improve physical and mental function in adults aged 60+ who have had a stroke and also have high blood pressure or diabetes. Over 400 participants from five Chinese cities will take part in 1…

This study tests whether fenofibrate, a drug typically used to lower blood fats, can slow the worsening of diabetic retinopathy (eye damage) in adults with type 1 diabetes. Over 400 participants take either fenofibrate or a placebo daily for three years. The goal is to see if the…

This study tests a new device called SEAL™ that is placed inside a brain aneurysm to block blood flow and prevent rupture. About 279 adults with unruptured or recently ruptured aneurysms are taking part. The goal is to see if the device safely and effectively seals the aneurysm w…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

This study tests whether adding neck stabilization exercises to a standard motor relearning program helps people recovering from a subacute stroke. Researchers will measure arm function, sensation, and quality of life in 96 participants over several weeks. The goal is to find a b…

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This study tests a one-time procedure to treat a rare brain blood vessel problem called Vein of Galen malformation while the baby is still in the womb. Doctors use a needle through the mother's abdomen and the fetal skull to place tiny coils that block the abnormal blood flow. Th…

This study tests a new device called the Ton-bridge carotid stent for treating carotid artery stenosis, a condition where the main arteries in the neck become narrowed, raising stroke risk. Researchers will compare it to a standard stent in 188 patients aged 18-80 who have signif…

This study follows 1,500 patients with multivessel coronary artery disease who were randomly assigned to receive either coronary stenting guided by fractional flow reserve or coronary bypass surgery. Researchers will compare survival, quality of life, and chest pain relief over 1…

This early-phase trial tests whether stem cells from donated umbilical cords are safe for people who recently had a stroke. Ten participants receive the cells through a vein or directly into the brain's arteries. Researchers monitor for side effects and look for any signs of impr…

This study tests whether high-intensity interval training (HIIT) on a stationary bike can improve heart rate variability—a key sign of recovery—in people who recently had a stroke. Fifty patients within three months of their first stroke will either do HIIT or low-intensity group…

This study tests a smart wearable airbag that detects when someone is falling and inflates to cushion the impact. It is designed for people at high risk of falling, such as those with stroke, Parkinson's disease, or a leg amputation. The goal is to see if the device can reduce fa…

This study tests whether giving melatonin to full-term newborns with hypoxic-ischemic encephalopathy (HIE) — a type of brain injury from lack of oxygen at birth — can improve survival and reduce brain damage. Half of the 110 babies will receive a single dose of melatonin through …

This large trial tests whether a program led by village doctors can help control high blood pressure in rural China. Over 33,000 participants will receive training, discounted medications, and a simple treatment protocol. The study aims to see if this approach improves blood pres…

This pilot study tests whether a ketogenic diet—a high-fat, low-carbohydrate diet—is safe and feasible for children in the pediatric ICU with acute brain injuries like stroke or traumatic brain injury. The idea is that after injury, the brain may struggle to use sugar for energy,…

This early-phase study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The therapy a…

This Phase 2 trial tests whether the oral drug tonabersat can reduce retinal swelling in people with diabetic macular edema who still have good vision. About 128 adults with type 1 or 2 diabetes will take either tonabersat or a placebo daily for several months. The main goal is t…

This trial compares two surgical methods for diabetic patients with proliferative diabetic retinopathy who need vitrectomy. One method spares the central part of the retina (fovea), while the other removes the entire inner limiting membrane. The study will measure vision and eye …

This study tests whether giving the steroid methylprednisolone along with standard clot-removal treatment can lower the risk of death or severe disability in people who have had a major stroke. About 928 adults with a large blockage in a main brain artery will receive either the …

This study tests whether using a patient's gender, weight, and kidney function to calculate the starting dose of the blood thinner heparin gets patients to the right level faster than the standard flat rate. About 145 adults with blood clots, atrial fibrillation, or mechanical he…

This study planned to compare taking blood thinners for 3 months versus 6 months after placing a special drug-coated stent in a narrowed brain artery. The goal was to see if the shorter treatment was just as good at preventing strokes and bleeding. However, the trial was withdraw…

This study is checking whether the Accero stent is safe and works well for people with brain aneurysms. Researchers are following 130 patients who already received the stent as part of routine care. They will use imaging and disability scales to see how patients do over time.

This study is checking how well a device called the GORE® CARDIOFORM Septal Occluder works and how safe it is for people who have had a stroke caused by a hole in the heart (PFO). Researchers will follow 300 patients in Japan for 12 months after the device is implanted. The goal …

This phase 2 study tests a new treatment plan for diabetic macular edema, a condition that causes vision loss. Instead of waiting for severe swelling, patients receive two dexamethasone implants 12 weeks apart, then additional injections only as needed. The goal is to improve vis…

This study was designed to test a device called LAmbre Plus, which is implanted to seal off a small pouch in the heart where clots can form in people with atrial fibrillation. The goal was to see if it could safely prevent strokes in patients with large or irregularly shaped hear…

This study tests whether a nerve block in the neck can increase blood flow to the brain in people who develop narrowed blood vessels after a bleeding stroke. Ten adults in the ICU will receive the block, and researchers will measure changes in blood flow and neurological function…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This study evaluates RDX-Aneurysm, a computer-assisted detection software designed to help radiologists find saccular intracranial aneurysms (bulging blood vessels in the brain) on MRI scans. Researchers will analyze 550 past scans—half with confirmed aneurysms and half without—t…

This study tests a laser-based imaging method that shows blood flow in the brain in real time during surgery. It involves 20 adults having brain surgery for conditions like aneurysms. The goal is to see if this technique can give surgeons continuous feedback, unlike the current d…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study tests whether using artificial intelligence (AI) to screen for diabetic eye disease during regular primary care visits helps more people get timely eye exams and follow-up care. About 1,700 adults with diabetes who haven't had an eye exam in the past year will take par…

This study tests whether smartwatches can detect atrial fibrillation (AF) in people who recently had a stroke. Participants already have an implanted heart monitor (the gold standard) and will also wear a smartwatch for 12 weeks. The goal is to see how well the smartwatch catches…

This study aimed to see if a handheld device called CPMX3 could safely estimate brain pressure in children by measuring pressure in a forehead vein. It planned to compare these readings with standard invasive measurements in children aged 8 to 21 who already had brain pressure mo…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study tests whether a special MRI technique called MR elastography can accurately measure high pressure inside the skull without needing a lumbar puncture (spinal tap). Researchers will compare the MRI results with standard tests in 200 people with and without high brain pre…

This study is testing whether monthly 12-lead ECG screenings at family health centers can detect undiagnosed atrial fibrillation (AF) in adults aged 65 and older. Participants will have 12 monthly visits over a year, and if AF is found, they will be started on blood thinners to r…

This study is testing whether an artificial intelligence (AI) program can spot early signs of diabetic retinopathy—a condition that can lead to blindness—in people with prediabetes and diabetes. Researchers will take pictures of the retina and use the AI to analyze them. The goal…

This study tests whether an AI program can find unruptured brain aneurysms on standard CT scans that people already get for other reasons. Ten adults with risk factors (like high blood pressure or being over 40) will have their scans checked by AI and then by a radiologist. The g…

This study tests an artificial intelligence system called i-ROP DL that analyzes images of the back of the eye. The goal is to see if it helps eye doctors more accurately diagnose retinopathy of prematurity (ROP), a condition that can cause blindness in premature infants. Researc…

This study tests whether using artificial intelligence (AI) to screen for diabetic retinopathy is faster and more accessible than the usual method with an eye doctor. About 548 adults with diabetes will be randomly assigned to either standard screening or AI-based screening using…

This study is testing whether a new risk score can help find people who have atrial fibrillation (an irregular heartbeat) but don't know it yet. About 1,955 adults at higher risk will use a remote ECG monitor at home. The goal is to see if the risk score correctly identifies who …

This trial asks whether hydroxyurea, a daily oral medication, can reduce the risk of a first stroke in children with sickle cell anemia. Researchers will use transcranial Doppler (TCD) ultrasound to measure blood flow in the brain, a key indicator of stroke risk, in children aged…

This trial is testing a device called the Vine™ Embolic Protection System, which is implanted in the carotid arteries to trap blood clots before they travel to the brain. It is designed for people with atrial fibrillation who are already taking blood thinners but still have a hig…

This study tests whether a music-inspired community campaign, called Music4Health, can help lower blood pressure and improve stroke awareness among 1,412 youth (ages 14-24) and their caregivers (ages 40+) in Nigeria. Participants will take part in listening sessions and activitie…

This study looks at whether clopidogrel, a blood thinner, can prevent new silent brain infarctions (small, unnoticed strokes) in people who recently had a stroke or mini-stroke. Researchers will track 134 participants over 24 months using MRI scans and cognitive tests. The goal i…

This study tests an investigational drug called OHB-607 to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature infants. About 338 babies will be randomly assigned to receive either the drug or standard care. The goal is t…

This trial tests whether a combination of lifestyle interventions—brain training, yoga, music therapy, and a special diet—can slow or reverse early signs of neurological disorders like dementia, stroke, epilepsy, and Parkinson's disease. Participants are healthy adults aged 50 an…

This study tests whether following the MIND diet for 2 to 3 years can slow cognitive decline and reduce dementia risk in people aged 55 and older who have had an ischemic stroke. The MIND diet combines elements of the Mediterranean and DASH diets, with extra emphasis on leafy gre…

This pilot study tests a personalized lifestyle program for young adults (18-65) who have had a stroke or high-risk mini-stroke. The program includes intensive counseling on diet, exercise, and smoking, plus a wearable device to track health. Researchers want to see if this appro…

This study tests whether closing a small pouch in the heart (the left atrial appendage) during heart surgery can prevent strokes and blood clots. About 6,500 adults at risk for atrial fibrillation and stroke are taking part. The goal is to see if this simple addition to surgery i…

This study tests whether desvenlafaxine, a drug typically used for depression, can help prevent migraines in adults who have frequent attacks. Researchers will compare the drug to a placebo in 440 participants over 12 weeks. The goal is to see if it reduces the number of migraine…

This study tests whether collecting sexual health information electronically during routine gynecologic visits can increase the use of PrEP, a medication that prevents HIV. About 1,170 women aged 15-65 who are not living with HIV will participate. The goal is to see if this appro…

This study tests whether closing the left atrial appendage—a small sac in the heart where blood clots often form—during planned heart surgery can prevent strokes in people with atrial fibrillation. About 1500 patients having coronary bypass or valve surgery are included. The goal…

This phase 3 trial tests whether adding regular, personalized exercise to standard medical care can prevent new strokes in 1300 people with symptomatic intracranial arterial stenosis (narrowed arteries in the brain). Participants are randomly assigned to either standard care or s…

This trial investigates whether adding focused shock wave therapy to standard Botox injections can better ease foot stiffness and improve walking in people with post-stroke spastic equinovarus foot. Participants are randomly assigned to receive Botox alone, shock waves just befor…

This study tests a new exercise therapy called Progressive Abduction Loading Therapy for people who recently had a stroke. The goal is to reduce a common arm problem called 'flexion synergy' that makes it hard to reach outward. 86 participants will receive either the new therapy …

This trial explores whether an affordable robot can help people with HIV who have had a stroke improve their arm and leg function. Participants will use the robot for rehabilitation exercises, and researchers will measure changes in movement, balance, and quality of life. The goa…

This trial explores whether five daily sessions of a gentle brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce fatigue in people who have had a stroke. Participants will receive either real or sham stimulation, and their fatigue levels wi…

This study is testing a robotic lower-limb exoskeleton combined with functional electrical stimulation (FES) to help people with conditions like spinal cord injury, brain injury, or multiple sclerosis improve their walking. The device provides robotic support and electrical stimu…

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

This pilot study is testing whether yoga-based movements, done online or in person, can help people with chronic migraine or cluster headache. Twenty adults aged 18-65 will participate. The goal is to see if yoga improves headache frequency, sleep quality, and overall well-being …

This study tests an 8-week app-based breathing program that uses heart rate feedback to help people with chronic migraine. Thirty adults will use the app daily for 10 minutes, and researchers will track changes in migraine frequency and psychological well-being. The goal is to se…

This study tests whether a mindfulness-based program (MBCT) delivered by phone or video can help people with migraines and depressive symptoms. About 145 adults with 4-20 headache days per month and mild to moderate depression will be randomly assigned to phone, video, or usual c…

This study investigates whether keeping a headache diary helps adults with migraine feel better and manage their condition. Participants track their headaches in a virtual diary, and researchers measure changes in quality of life and disability. The goal is to see if this low-cos…

This study tests whether adding home-based telerehabilitation via WhatsApp video calls to standard outpatient therapy improves hand function in people who had a stroke 1-6 months ago. Forty-eight participants will be split into two groups: one gets standard therapy plus daily 30-…

This study tests whether combining neuromuscular electrical stimulation (NEMS) with voluntary muscle contraction can improve ankle function in people with chronic stroke. Twenty-five participants will either receive conventional physiotherapy or NEMS plus active dorsiflexion exer…

This study tests a device called GaitBetter that combines treadmill walking with cognitive training (like thinking tasks) to help stroke survivors improve their walking and balance. About 76 people who had a stroke (either within 8 weeks or more than 6 months ago) will use the de…

This early study tests a new device called PRIMUS that stimulates nerves in the head and face to treat chronic migraine. Only 7 people with hard-to-treat migraines are taking part. The main goal is to see if the device is safe, not yet if it works.

This study explores whether dry needling — a technique where thin needles are inserted into tight muscles to trigger a twitch — can reduce spasticity (stiffness) in people who have had a stroke. Researchers will measure changes in nerve pathways and movement over two visits. The …

This study compares two types of exercise—open kinetic chain (like leg raises) and closed kinetic chain (like squats)—to see which better reduces knee hyperextension in stroke survivors. Sixty adults who have had a stroke and can walk with some help will be randomly assigned to o…

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study tests a short, high-dose form of brain stimulation called repetitive transcranial magnetic stimulation (rTMS) in 20 people who had a stroke at least 6 months ago. The goal is to see if it is safe and acceptable, and whether it can improve cognitive problems like memory…

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 with conditions like cerebral palsy improve their swimming safety, arm function, and ability to do daily tasks. Children attend sessions twice a week for ten weeks. Researchers will measure chan…

This study tests whether an injection of hyaluronidase can reduce muscle stiffness and spasticity in the arm after a stroke. 56 adults with moderate-to-severe stiffness will receive either the study drug or a placebo, and later switch to the other option. The goal is to improve r…

This study tests two different movement training methods—sprinter-style and skater-style—to see which better improves balance and coordination in people who had a stroke at least six months ago. Twenty-two participants will do 30-minute sessions three times a week for four weeks.…

This study looks at whether a 60-day nerve stimulation device placed near the back of the head can help people with stubborn headaches. Researchers will track pain levels, daily function, and how often participants need emergency care. About 300 adults with various headache types…

This study looks at whether an 8-week mindfulness course can help people who had a stroke at least 6 months ago. About 28 participants will take the course either right away or after a wait. The goal is to see if the course is practical and if it improves emotional well-being and…

This study compares two types of hand and arm therapy for people who had a stroke 3 to 6 months ago. One therapy involves restraining the good arm to force use of the affected arm, while the other focuses on using both arms together. Both groups also receive standard physical the…

This study compares two treatments—Functional Electrical Stimulation (FES) and Whole Body Vibration Training (WBVT)—to see which better improves leg control, balance, and daily activities in people who had a stroke 6 months to 1 year ago. Thirty-four adults aged 35 to 70 will rec…

This study compares two physical therapy approaches—Rood's techniques (using touch, stretch, and ice) and PNF patterns (diagonal movements)—to improve arm and hand function in people who recently had a stroke. 28 adults aged 40-60 with a first-time stroke will receive one of the …

This study compares two physical therapy techniques—PNF and NDT—to see which better helps stroke survivors improve trunk control and balance. It will involve 32 people aged 40-65 who have had a recent stroke. Participants will receive electrical stimulation plus one of the two th…

This study tests whether a special arm brace that reads muscle signals can help stroke survivors with severe arm weakness recover better during early rehabilitation. Three veterans who had a stroke within the past 6 months will use the device alongside standard therapy. The goal …

This study tests whether early, intensive leg exercises, done by a physical therapist and a parent together, can improve walking and motor skills in children aged 8 months to 3 years who had a stroke around birth. The study compares this approach to usual care. The goal is to see…

This study compares two rehabilitation methods—somatosensory stimulation (using touch) and task-based mirror therapy (using a mirror to trick the brain)—to see which better improves arm and hand function in stroke survivors. About 24 adults who had a stroke 1 to 6 months ago will…

This study tests whether combining gentle touch stimulation with nerve exercises can improve arm movement and feeling in people who had a stroke 6-12 months ago. 53 adults aged 45-65 with lasting arm weakness and sensory loss are participating. The goal is to see if this therapy …

This study compares two types of exercise programs to see which one better improves balance and leg movement in people who have had a stroke. The study includes 52 adults aged 45 to 65 who had a stroke 6 to 10 months ago and have mild to moderate leg weakness. Participants will d…

This study looks at whether a treatment called pulsed radiofrequency (PRF) on a nerve at the back of the head can help people with migraines. Researchers measured pain sensitivity and disability in 100 adults before and up to 3 months after the procedure. The goal is to see if th…

This study tests whether exercising both legs together (bilateral training) or just the affected leg (unilateral training) with visual feedback from mirrors and floor targets works better for improving balance, walking, and sensation in people who had a stroke. Fifty participants…

This study tests whether a brief behavioral class called Empowered Relief can reduce disability and symptoms in adults with chronic migraine. 300 participants will be randomly assigned to the class, a health education session, or usual care, all done remotely. The goal is to see …

This small study tests whether a four-session program combining music and nature activities can improve wellbeing for people with acquired brain injuries and their care partners. Ten adult participants will complete surveys before and after the program. The goal is to see if this…

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve speech recovery in people with aphasia after stroke or brain injury. Twelve adults with apraxia of speech will receive either active or sham stimulation during 16 wee…

This pilot study tests whether a 7-week virtual lifestyle medicine program can help teens aged 14-18 with frequent migraines. Participants attend weekly group sessions covering sleep, nutrition, stress management, physical activity, and social connection. The main goal is to see …

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time. Participants either get 12 behavioral coaching sessions or 6 health education sessions. The goal is to see if the program improves quality of life …

This study planned to test whether an augmented reality (AR) app called Reia could help stroke survivors with arm weakness do rehab exercises at home. Participants would have used an AR headset for daily 30-minute sessions over 8 weeks, with weekly video check-ins from a therapis…

This study is testing a new device that uses gentle vibrations on the belly, back, or temples to help people with chronic pain conditions like pelvic pain, abdominal pain, low back pain, or migraine. About 50 adults will try the real device or a placebo to see if it safely reduce…

This early study tests the safety of a new device called PRIMUS that uses mild electrical pulses on nerves in the forehead and back of the head to treat chronic cluster headache. Five people with frequent, hard-to-treat attacks will be enrolled. The goal is to see if the device i…

This study tests a device that uses mild electrical pulses to treat chronic migraine. About 250 adults with frequent, hard-to-treat migraines will receive either the active device or a sham (inactive) device. The goal is to see if the device safely reduces the number of headache …

This study compares a new numbing gel (chloroprocaine HCl 3%) to standard eye drops plus a shot for pain relief during eye injections. About 236 adults with conditions like diabetic macular edema or age-related macular degeneration will take part. The goal is to see if the gel wo…

This study tests whether acceptance and commitment therapy (ACT), delivered via online video calls, can help stroke survivors adjust emotionally. Five adults who had a stroke over three months ago will attend weekly 90-minute group sessions for eight weeks. Researchers will track…

This study tests whether a program combining exercise, healthy eating advice, and education about migraine can reduce the number of attacks in people with frequent or chronic migraines. About 140 adults who are not very active will take part. The goal is to see if lifestyle chang…

This study tests an online program called Migraine Manager for teens aged 11 to 17 with frequent migraines (8 or more per month). The tool gives personalized tips on healthy habits like drinking water, eating regularly, exercising, and sleeping well. Researchers will compare 80 t…

This study tests whether inhaling lavender, peppermint, or a mix of both can change how sensitive people with migraine are to pressure pain. Two hundred adults with migraine will inhale one of the oils or a control solution for 15 minutes. Researchers measure pain thresholds befo…

This study tests whether vibrating the tendons, combined with robotic arm training, can improve arm and hand movement in people who had a stroke at least 6 months ago. 40 participants will receive the therapy, and researchers will measure changes in motor function and body awaren…

This study tests whether mirror therapy can help people who have had a stroke regain movement and reduce pain in a weak arm. Participants do arm exercises while watching the reflection of their good arm, which tricks the brain into thinking the weak arm is moving. The trial invol…

This pilot study tested three different strengths of inhaled cannabis (2.5%, 5%, and 10% THC) against a placebo to see if they could quickly relieve migraine headaches. Twenty adults with migraine took part in a crossover design, meaning each person tried all options. The main go…

This study tests whether adding an interactive screen (MYRO) to standard therapy helps people who had a stroke and have trouble paying attention to one side of their world (left neglect). About 30 adults with a recent stroke will be split into two groups: one gets standard therap…

This study tests whether a mild electrical current applied to the brain (tDCS) during speech therapy can improve language recovery in people with aphasia after a stroke. Two hundred adults with language problems from left-brain damage will receive either real or fake stimulation …

This study tests a small device that sends gentle electrical pulses to nerves far from the head (called Ultra-Distal TENS) to see if it can reduce migraine pain and related symptoms like nausea and sensitivity to light or sound. About 206 adults with frequent migraines will use t…

This study planned to test whether a soft robotic exosuit worn on the ankle could help stroke survivors walk better. Participants would have done high-intensity gait training with or without the exosuit. The goal was to see if the suit could improve walking distance and speed. Ho…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study was designed to compare a tiny steroid insert (Dextenza) placed in the tear duct against standard steroid eye drops (prednisolone) after cataract surgery in people with diabetes. The goal was to see which better controls eye inflammation and swelling. However, the stud…

This study tests whether taking vitamin K2 supplements for one year can improve muscle strength and brain function in people who recently had an ischemic stroke. 190 participants will receive either vitamin K2 or a placebo daily. Researchers will measure handgrip strength and oth…

This study tests whether adding a mild electrical stimulation to the neck muscles can help people who recently had a stroke and now have trouble swallowing. Forty participants will receive either standard swallowing therapy or therapy plus electrical stimulation. The goal is to s…

This study compares two approaches to help stroke survivors with mild to moderate thinking problems. Both groups use a web-based computer game that trains how quickly they process information. One group also gets in-lab training on everyday activities, while the other focuses on …

This study tests a telehealth program called TASK III for people caring for a family member after a stroke. The program includes a resource guide and eight weekly calls from a nurse to help caregivers build skills and manage their own health. Researchers will measure changes in c…

This study tests whether adding touch and sound feedback to standard mirror therapy can improve arm function in stroke survivors with arm weakness. Eighty-four participants will be split into three groups: one gets the enhanced therapy, one gets digital mirror feedback only, and …

This study tests a new automated walking trainer that uses sensors and cues to help stroke survivors improve their gait. The device aims to make repetitive walking practice easier and more effective than traditional therapist-led training. The study will enroll 60 adult stroke su…

This study tests whether a virtual reality (VR) headset can help people who have had a stroke improve arm movement. Eighteen adults in Ethiopia will use the VR system for nine sessions over three weeks. Researchers will measure how usable and comfortable the system is, and also c…

This study tests whether combining a gentle brain-stimulation technique (transcranial direct current stimulation) with core stability exercises can improve trunk control, balance, and walking ability in people who have had a stroke. Sixty participants aged 55 and older who had a …

This study tests a new program called PA-ChatS that helps people increase physical activity in the first 6 weeks after a stroke. Participants wear a Fitbit to track steps and have weekly phone meetings with an occupational therapist for 6 weeks. The study includes 25 stroke survi…

This study tests a new device that helps stroke survivors improve their walking. The device uses mechanical support and sound cues to guide natural walking patterns. The trial will enroll 40 adults who have had a stroke and can walk without help. The goal is to see if the device …

This study looks at how well Rimegepant works for treating migraine attacks in everyday life. About 3,000 adults with migraine will take the drug as prescribed by their doctor and report their pain levels, relief timing, and satisfaction. The goal is to see if Rimegepant helps re…

This study tests a remotely delivered 8-week program called ReStoreD for couples where one partner has had a stroke. The program teaches goal-setting, communication, and positive thinking skills to reduce anxiety and depression. Researchers will enroll 400 couples to see if the p…

This study tests whether balance training guided by artificial intelligence can improve pelvic alignment and reduce fall risk in people who have had a stroke. Thirty-eight stroke survivors will wear sensors and perform static and dynamic balance exercises. The AI adjusts the exer…

This study compares two common eye injection drugs, aflibercept and bevacizumab, in adults aged 30-60 with diabetic macular edema (fluid buildup in the retina causing vision loss). About 116 participants will receive monthly injections for two months. The goal is to see which dru…

This study tests whether giving premature babies a pacifier dipped in breast milk during eye exams for retinopathy of prematurity can reduce pain and improve comfort. About 56 infants born before 32 weeks will be randomly assigned to receive either standard care or the pacifier. …

This study tested whether a nasal spray called zavegepant could relieve migraine pain within 2 hours. Adults with migraines for at least a year were to use the spray at home for up to 4 attacks. The study was withdrawn before enrolling participants, so no results are available.

This study looks at whether using the Nerivio wearable device more frequently than the label says is safe for people with migraines. About 2000 participants who already use Nerivio will use it at higher frequencies. The goal is to check for side effects and see if it remains safe…

This pilot study is testing whether memantine, a drug already used for Alzheimer's, can improve arm and leg function after an ischemic stroke. Twenty participants with arm weakness will receive either memantine or a placebo for several weeks. The study measures motor skills and t…

This study tests whether using a robotic exoskeleton for arm exercises helps people who had a stroke recover arm function better than standard therapy. About 70 adults with moderate to severe arm weakness within 90 days of their first stroke will participate. The goal is to see i…

This study looks at whether acupuncture can reduce migraine pain and lower signs of inflammation and brain stress in the blood. Researchers will compare three types of gentle stimulation: laser, electro, and traditional acupuncture. 75 adults with migraines will receive treatment…

This pilot study aimed to test whether a virtual reality (VR) cooking simulation could improve arm movement and daily function in people with acquired brain injury. Participants would have used VR to practice reaching, grabbing, and stirring motions. However, the trial was withdr…

This study planned to test a combination of naltrexone and acetaminophen for treating migraine attacks. It was designed in two stages: first comparing the combo to each drug alone and placebo, then finding the best dose. However, the trial was withdrawn before any participants we…

This study tests whether a high-dose, intensive therapy program can improve arm movement and quality of life in people who had a stroke at least 6 months ago. Nine participants will receive 6 hours of therapy per day, 5 days a week, for 3 weeks, including occupational and physica…

This study looks at whether closed kinetic chain exercises (like squats) and kinesio taping can improve knee awareness, balance, and daily function in people who had a stroke more than six months ago. Thirty participants will be assigned to one of the two treatments. The goal is …

This study tests a device called the Neuromechanical Gait Assist (NMGA) that combines a powered knee brace with muscle stimulation to help people who have difficulty walking after a stroke. Five veterans with leg weakness and a stiff-legged gait will use the device in a lab while…

This study tests a new walking therapy for people who had a stroke more than 6 months ago. The therapy combines biofeedback (visual cues about how you walk) with aerobic exercise to improve walking symmetry. 50 participants will try the approach to see if it is feasible and what …

This study follows 500 adults under 45 who have narrowing of a major brain artery, a condition that can raise stroke risk. Researchers will track participants over time to see how the narrowing progresses and who goes on to have a stroke. The goal is to better understand the natu…

This study looks at whether tiny RNA particles called exosomal microRNAs in the blood can act as a 'stroke clock' for people with a severe type of stroke caused by a blocked large artery in the front of the brain. Researchers will compare blood samples from stroke patients to hea…

This study follows 46 people with gyrate atrophy, a rare genetic condition that causes vision loss, over 4 years. Researchers measure ornithine levels in the blood and track changes in the retina using eye scans and photos. The goal is to learn how the disease progresses under st…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective a…

This study follows 800 adults who have had their first ischemic stroke in Central Norway for up to 10 years. Researchers will track how physical activity, medication use, and control of blood pressure and cholesterol affect the risk of death, another stroke, or severe disability.…

This trial tests whether a treadmill that automatically adjusts its speed to the walker can help people with weakness on one side of the body take more even steps. Participants with hemiparesis from a stroke or traumatic brain injury will walk on both a self-pacing and a fixed-pa…

This study looks at how a soft robotic exosuit can help people who have had a stroke walk better. Researchers will measure muscle activity and walking patterns in 22 adults who are at least six months past their stroke. The goal is to see if customizing the exosuit's assistance b…

This study looks at whether data from wearable devices like smartwatches can track and even predict migraine headaches. Twenty adults with chronic migraine will use a phone app and a smart device to record heart rate and movement. The goal is to see if this information can help f…

This study investigates whether people with neurodegenerative diseases—like Alzheimer's, Parkinson's, or ALS—show changes in behavior, social circumstances, or health before and after their diagnosis. Researchers will compare the records of over 61,000 patients with those of matc…

This study follows 1,000 patients in China who are already receiving faricimab for diabetic macular edema, retinal vein occlusion, or wet age-related macular degeneration. Researchers will collect data from routine clinic visits over one year to see how well the drug works and ho…

This study looks at balance and movement problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use special devices to measure how well participants can keep their balance and walk. The goal is to learn more about these issues so that rehabil…

This 5-year study follows 250 people with von Hippel-Lindau disease who have brain or spinal cord tumors. Researchers use regular MRI scans and blood tests to see how fast tumors grow and what factors like hormones might affect growth. The goal is to better understand which tumor…

This study tested a new MRI method to better predict stroke risk in people with intracranial atherosclerosis, a condition where arteries in the brain become narrowed. Researchers measured how well different parts of the brain responded to changes in blood flow. The goal was to fi…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study looks at whether stroke patients who do high-intensity rehab at home recover just as well as those who go to a rehab facility. Researchers will follow 500 patients who choose home rehab and compare their progress to patients who went to inpatient rehab. The goal is to …

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study tests whether everyday rehabilitation therapy sessions can be recorded and measured more objectively using wrist-worn sensors, a video camera, and an audio recorder. Adults with neurological conditions like stroke, Parkinson's disease, or spinal cord injury will wear t…

This study tests whether a new scoring system, called PRO-ICH, can accurately predict how well people will recover after a spontaneous brain hemorrhage. Researchers will also check if adding certain blood markers improves the score's accuracy. The goal is to give doctors a reliab…

This study looks at whether using wearable devices and a mobile app can help people who have had a stroke improve their walking and daily activity during a 6-week home exercise program. About 120 adults who can walk but have some difficulty will be split into two groups: one usin…

This study tests whether pairing vagus nerve stimulation (VNS) with language training can improve memory and learning in people who have already used VNS for movement recovery after a stroke. Participants, who already have a VNS implant, will try learning a new language while the…

This long-term study follows over 121,000 female nurses to explore how hormones, diet, lifestyle, and genetics affect the risk of heart disease and stroke. Researchers are analyzing blood samples to create a 'metabolomic risk score' that could help predict coronary heart disease.…

This study looks at how short bursts of aerobic exercise affect brain function in older adults and stroke survivors. Researchers will compare three groups: one doing moderate cycling to raise lactate levels, one doing light cycling, and one receiving health education only. Partic…

This observational study looks at how inserting a central venous catheter into the neck affects pressure inside the skull in patients with acute brain injury. Researchers will monitor brain pressure, blood flow, and oxygen levels during and after the procedure in about 120 ICU pa…

This study uses a non-invasive eye scan called OCTA to examine tiny blood vessels in the retina of adults with type 1 diabetes. The goal is to detect early signs of diabetic retinopathy, a leading cause of vision loss, before symptoms appear. Researchers will measure vessel densi…

This study investigates how people physically interact with each other during tasks like collaboration, competition, and cooperation. The goal is to design robot controllers that mimic these human behaviors, which could then be used in devices like exoskeletons to improve motor l…

This study investigates how the brain coordinates muscle activity during walking rehabilitation in people recovering from a stroke. Researchers use high-density electromyography (HD-EMG) to track neural synergies—groups of muscles that receive common signals from the brain—over t…

This study examines how ankle impairments affect walking ability in people who had a stroke at least six months ago. Researchers use a robotic device to measure ankle control and sensation, comparing results with standard walking tests and clinical scales. The goal is to develop …

This study looks at how a stroke affects the jaw joint and chewing muscles. Researchers will use ultrasound to measure jaw structures in 70 stroke survivors and see if these measurements relate to their recovery. The goal is to better understand jaw problems after a stroke, which…

This study looks at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. Participants have mild memory concerns or are at risk for cognitive decline.…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This study tests a 12-month community program (SCIP) for older adults in rural Ecuador. It includes group activities, peer support, and home coaching to reduce loneliness. Researchers will measure changes in social isolation, heart health, memory, and mood in 500 people aged 60 a…

This study follows 250 people who had a type of stroke called intracerebral hemorrhage (ICH) to understand why some experience progressive cognitive decline. Participants undergo advanced brain scans and tests of thinking and movement at 12–24 months after their stroke, with foll…

This trial investigates whether measuring high-sensitive troponin, a protein released during heart injury, can predict heart complications in people undergoing surgery to open a narrowed carotid artery. About 527 participants will have their troponin levels checked before and aft…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…

This observational study tracks 5,000 people taking common blood thinners (like rivaroxaban or apixaban) or antiplatelet drugs (like aspirin). Researchers regularly measure drug levels in the blood to see how they relate to clots or bleeding events. The goal is to find the best d…

This study follows 214 men treated for prostate cancer to see how many develop lower limb lymphedema (leg swelling) and who is most at risk. Participants attend check-ups every three months for 18 months. The goal is to better understand this side effect and its impact on quality…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study looks at 1,000 patients on blood thinners who had a minor head injury and a normal first CT scan. Researchers want to see if a second CT scan 24 hours later finds any delayed brain bleeding. The goal is to understand whether the extra scan is needed and how often it le…

This study looks for tiny plastic particles in brain tissue removed during surgery for spontaneous bleeding. Researchers will test if these plastics are linked to more inflammation and worse recovery in 150 patients. No new treatment is given; the goal is to understand if environ…

This study was designed to use a special PET scan to measure brain inflammation in people with asymptomatic carotid artery disease (narrowing of neck arteries without symptoms). It aimed to compare inflammation levels between those with high-grade and low-grade narrowing. However…

This study aims to help adults aged 40 and older in Upper Manhattan get better eye care. It will offer free eye screenings at local health centers and senior centers, and provide support like scheduling appointments and transportation. The goal is to see if this extra help leads …

This study looks at whether having a rehabilitation doctor see stroke patients early in their hospital stay can shorten how long they stay and reduce the chance of coming back. Researchers are tracking 3,000 stroke patients to see if this coordinated care approach improves recove…

This study looks at why people with antiphospholipid syndrome (APS) — a condition that raises blood clot risk — may have narrowed brain arteries. Researchers will use advanced MRI scans on 60 APS patients to check for artery narrowing and plaque buildup. The goal is to better und…

This registry follows 63 patients with choroidal melanoma or early eye lesions who were treated with the experimental drug bel-sar in earlier studies. The goal is to monitor long-term safety, side effects, and any spread of the disease over time. Participants are not receiving ne…

This study looks at how newer diabetes medications (SGLT2 inhibitors and GLP-1 receptor agonists) affect the eyes of people with type 2 diabetes. Researchers will monitor 40 adults who take metformin and are starting these newer drugs. The goal is to see if these drugs cause any …

This study looks at whether brain scans can help predict which people with migraine will respond to a class of drugs called CGRP antibodies. Researchers used MRI to measure brain structure, activity, and blood flow in 219 adults with frequent migraine before and after 12 weeks of…

This study uses brain scans to see how the brainstem and other brain areas respond to mild electrical pulses on the face and arm in 40 healthy volunteers. The goal is to better understand the brain circuits involved in facial pain and touch, which could help future research on mi…

This study looks at whether a program called I-SITE can help rural health clinics use teleophthalmology (remote eye exams) to screen more diabetic patients for eye problems. Up to 10 health systems and 10,000 patients will take part. The goal is to see if screening rates improve …

This study looks at 45 people having carotid artery surgery to see if special brain scans can predict improvements in thinking and memory. Researchers will use PET/CT scans to measure inflammation in the brain and MRI to examine plaque in the carotid artery. The goal is to find i…

This observational study examines how aflibercept 8 mg, an injection into the eye, is used in routine care for patients in Japan with age-related macular degeneration or diabetic macular edema. Researchers will analyze claims data from about 3000 patients to understand patient ch…

This study collects movement data from 250 people with stroke, Parkinson's disease, or leg amputations using wearable sensors and video. The goal is to build an online database that researchers can use to study how people move and recover. No treatments are being tested—this is p…

This study looks at whether blood flow restriction training (using tight bands on the legs during exercise) can improve walking in people who had a stroke at least 6 months ago. 40 participants, aged 40-65 with mild leg stiffness, will do resistance exercises with or without bloo…

Most stroke survivors struggle to stay physically active after rehab, raising their risk of another stroke. This study works with survivors, carers, and staff to design a program that supports long-term activity. 34 participants will help shape and test the program.

This study looks at whether MRI or CT should be the first scan for people with suspected acute ischemic stroke. Researchers will track how often doctors follow the assigned scan type and compare outcomes. The goal is to see if a larger study comparing these imaging methods is pos…

This observational study follows about 236 adults with diabetic macular edema (DME) who did not respond well to anti-VEGF injections and are now starting treatment with a dexamethasone implant (DEX-I). The implant slowly releases steroid medication into the eye. Researchers will …

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study follows over 2,400 adults in Korea who have had their first stroke. Researchers will track their recovery, daily activities, and quality of life for 10 years. The goal is to learn what factors help or hinder long-term recovery after a stroke.

This study looks at 100 people having a mechanical thrombectomy (clot removal) for a major stroke. Researchers will monitor their blood sugar continuously during the procedure and check recovery 3 months later. The goal is to see if lower blood sugar at the time of reperfusion (w…

This study looks at two different blood pressure goals for adults who just had brain tumor surgery. Half the patients will have a target of less than 160 mmHg, the other half less than 140 mmHg. Researchers want to see which group leaves the hospital sooner, without more bleeding…

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study is creating a simple test to check if people with Alzheimer's or similar conditions can understand and agree to medical decisions. Researchers will work with 100-150 participants to compare the new test with existing methods and look at brain scans and blood markers. T…

This study looks at whether a coordinated emergency system, like those used for trauma, can help more severe stroke patients get a clot removal procedure called mechanical thrombectomy. Researchers will compare data from before and after the system is put in place across Alabama.…

This study was designed to see how changing the head position affects pressure inside the skull in people who had a brain bleed from a burst aneurysm. It planned to monitor adults with a pressure monitor already in place. However, the study was withdrawn before enrolling anyone, …

This study looks at how activating muscles changes the way people who have had a stroke perceive touch. Researchers will measure the smallest electrical pulse that can be felt on the fingertips while muscles are at rest and while they are active. The goal is to better understand …

This study tests whether watching storytelling videos can help African American and Black patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners to prevent strokes. About 80 adults who are not currently on blood thinners but have a hig…

This study looks at 20 adults who had a stroke within the past week. Each person will get both a CT scan and a PET scan of the brain to see which method better shows blood flow and metabolism. The goal is to find the best way to image stroke damage, not to test a new treatment.

This study looks at how social factors like income, education, and lifestyle might influence the risk of a brain aneurysm bursting. Researchers will analyze data from 1,800 patients using artificial intelligence to find patterns. The goal is to improve risk prediction and help pr…

This study looks at whether stopping overnight neurological checks in stroke patients can help prevent delirium, a common and serious complication. Researchers will compare patients who continue standard overnight checks with those who have them stopped, measuring rates of deliri…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study was designed to track hidden symptoms like memory or concentration problems in people recovering from a brain bleed (subarachnoid hemorrhage). Researchers planned to follow patients for one year using questionnaires to see how these symptoms affected daily life and ret…

This study compares 120 adults with primary headaches (migraine or tension-type) to healthy individuals. Researchers will measure tenderness in head and neck muscles and general pain sensitivity elsewhere in the body. The goal is to understand how these factors relate to headache…

This study follows 1,000 stroke survivors and their caregivers to understand how social factors and discrimination affect recovery. Researchers will survey participants over time to measure outcomes like quality of life and caregiver strain. The goal is to identify why some group…

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study looks at spinal fluid and blood from 150 adults who had bleeding from a brain aneurysm. Researchers use a special laser technique to find proteins and genes that might predict when dangerous blood vessel spasms will happen. The goal is to better understand these marker…

This study follows about 100 premature babies who were treated for retinopathy of prematurity (ROP) in an earlier study. Researchers will check their eyesight and overall development over time to see how they are doing. No new treatment is given in this study.

This study looks at how virtual reality affects stroke patients, specifically checking for motion sickness. Researchers will measure heart rate, blood pressure, and use a special questionnaire to see if VR causes discomfort. The goal is to understand and improve the use of VR in …

This study tests whether a small device placed under the skin can detect hidden atrial fibrillation (an irregular heartbeat) in people with heart failure who are at high risk for stroke. About 477 participants either received the implant or standard care. The goal is to see if th…

This study tests a new handheld tool that measures muscle stiffness (spasticity) in people who have had a stroke. Researchers want to see if the device gives the same or better results than standard clinical tests. The study involves 40 adults aged 18-75 with a history of stroke …

This study brings together stroke survivors, families, staff, and researchers to co-design a toolkit that helps everyone follow trial protocols in inpatient stroke rehabilitation. The goal is to reduce missed sessions and errors, making trial results more trustworthy. About 38 pe…

This study looks at whether short bursts of breathing air with less oxygen (like at high altitude) can improve arm and hand function in people who had a stroke at least six months ago. Twenty participants will undergo 15 cycles of one-minute low-oxygen breathing followed by norma…

This study compares two methods to detect reduced blood flow to the brain during carotid artery surgery: asking awake patients to move their hand versus using a near-infrared spectroscopy (NIRS) headband. The trial involves 160 people with narrowed carotid arteries. The goal is t…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study measures how much force leg muscles can produce and how they use oxygen in people with stroke or sarcopenia (age-related muscle loss). Researchers will test hip, knee, and ankle strength at different angles and speeds. The goal is to gather data that could help design …

This study follows over 50,000 Chinese adults who were first surveyed between 2011 and 2014. Researchers will check how chronic lung, heart, metabolic diseases, and cancers have developed or changed over more than a decade. The goal is to understand how multiple health problems o…

This study looks at whether a blood test can help doctors figure out when a stroke began. This is important because some people wake up with stroke symptoms and don't know the exact start time, which can prevent them from getting clot-busting drugs. Researchers will take blood fr…

This study looks at whether a sticker-like sensor on the skin can accurately measure carbon dioxide levels in newborns with brain injury who are receiving cooling treatment. About 53 babies will take part. If it works, it could replace frequent blood draws and make monitoring eas…

This long-term study uses yearly brain scans, genetic tests, and thinking/memory assessments to track changes in nearly 1,800 people with various dementias (like Alzheimer's and vascular dementia) and over 140 healthy older adults. The goal is to better diagnose, monitor, and eve…

This study looks at whether a heart ultrasound (called TTE) can help prevent another stroke in people who have already had one. About 2,000 stroke patients who received a TTE will be followed to see if the test helped doctors change treatment and reduce the chance of a second str…

This study looks at whether artificial intelligence can improve predictions of serious heart events in people with chest pain. Researchers will analyze stress echocardiogram results and routine medical data from about 2,281 adults. No extra visits or tests are needed for particip…

This study aims to build a database of normal eye measurements from healthy children aged 6-15. Researchers will then compare these measurements with those from children who have type 1 diabetes. The goal is to better understand early signs of diabetic retinopathy, a condition th…

This study aims to understand how the brain changes after a stroke and how those changes relate to arm recovery. Researchers will use brain scans and electrical recordings to build a model that predicts recovery. The goal is to eventually personalize brain stimulation therapy to …

This study follows 1000 adults who have had a stroke to better understand how the brain recovers. Researchers use brain scans, electrical signals, and physical tests to find patterns linked to recovery. The goal is to improve predictions and treatments for stroke survivors.

This study looks at how headaches work by using capsaicin (the spicy part of chili peppers) and ice water to trigger mild, temporary pain in people with and without headache disorders. Researchers measure changes in pain signals and tear production to better understand conditions…

This study tests a program called I-SITE that helps clinics use teleophthalmology—taking eye photos during regular doctor visits—to increase screening for diabetic retinopathy. Over 12,000 patients with diabetes from urban health systems are included. The goal is to see if this a…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study looks at whether custom-made videos can help people who had a stroke 1 to 10 years ago better understand their condition and feel more satisfied with their care. About 100 participants will use a video app and answer surveys after 7 and 90 days. The goal is to see if t…

This study looks at whether common balance tests can tell doctors why a person is having trouble with balance. Researchers will test 330 people, including healthy volunteers and patients with stroke, vision problems, inner ear issues, spine problems, or spinal cord damage. The go…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study looks at how often nurses should check on people in the ICU after they have had a brain aneurysm treated. The goal is to see if checking every hour versus every two hours affects how well patients sleep. Thirty adults who had a planned aneurysm coiling will take part, …

This study looks at how well surgical and diagnostic techniques work for people with blocked carotid arteries, a major cause of stroke. Researchers will follow 60 patients to see how bypass surgery affects blood flow, thinking skills, and recovery. The goal is to find better ways…

This study followed 602 people who had a stroke to see how many later had seizures. Researchers looked at blood tests, brain scans, and EEG recordings to find clues that might predict who is at risk. The goal is to better understand why some stroke survivors develop epilepsy.

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study looks at how focused ultrasound (sound waves) aimed at the cerebellum changes brain activity and thinking in 20 healthy adults aged 18 to 40. Participants do thinking tasks after real or fake ultrasound. The goal is to learn how the cerebellum affects brain function, n…

This study is testing whether a brain-based biomarker can predict how well stroke survivors recover from spatial neglect—a condition that makes it hard to notice things on one side. Researchers will follow 45 Veterans for 6 months, measuring their daily living skills and neglect …

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study uses MRI scans to check for hidden brain aneurysms in close relatives (parents, siblings, or children) of people who have had a bleeding aneurysm. It aims to find who is at higher risk and how lifestyle factors like smoking or high blood pressure affect that risk. Abou…

This study looks at whether a special board game can help older adults (65-100) who had a mild to moderate stroke think about and share their preferences for life-sustaining treatments. The game uses travel themes and cards to make these tough conversations easier. Researchers me…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study tests a new computer-based visual training task for people who have lost part of their vision due to a stroke. Participants watch moving patterns on a screen and learn to detect motion direction, with the goal of improving visual abilities. The study first checks if th…

This study looks at whether platelet activation in the blood is higher in people whose brain aneurysm has already burst compared to those with an unruptured aneurysm. Researchers will collect blood samples from 230 patients during treatment. The goal is to see if platelet activit…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study looks at whether bacteria in the gut and mouth are linked to a higher risk of stroke in people with narrowed neck arteries. Researchers will measure certain waste products from these bacteria in the blood and see if they relate to stroke or worsening artery blockages. …

This study follows 400 people who had a brain aneurysm rupture and were treated with a procedure called embolization. The goal is to learn about their long-term recovery and whether the aneurysm can come back. Researchers will track neurological outcomes using a standard scale. T…

This study uses advanced MRI scans to measure blood flow in the brains of 100 adults with moyamoya disease, a condition that narrows major brain arteries and raises stroke risk. Participants will have scans and cognitive tests before and after their clinically needed surgery. The…

This study uses MRI scans to see how the brain's blood vessels react when people breathe in extra carbon dioxide. Researchers want to compare healthy adults and those with brain blood vessel diseases. The goal is to learn more about brain blood flow and oxygen use, which could he…

This study looks at how brain aneurysms (specifically intracranial dissecting aneurysms) change over time. Researchers are using high-resolution MRI scans and computer models to find patterns that might predict if an aneurysm will get worse. The goal is to build an AI tool that h…

The Brain Health Registry is an online project that collects information about memory, mood, sleep, diet, and exercise from adults over 18. Participants also take simple cognitive tests online. The goal is to build a large database to speed up research into brain diseases like Al…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study looks at people with rare adrenal tumors (pheochromocytomas and paragangliomas) that do not produce excess hormones. Researchers want to see if these 'silent' tumors still cause heart problems, blood pressure changes, or metabolic issues like diabetes and high choleste…

This study follows 30 people with mucopolysaccharidoses (MPS) over three years to see how their heart and arteries change. Researchers use neck ultrasounds and blood tests to measure artery thickness, stiffness, and signs of inflammation. The goal is to better understand cardiova…

This study looks at brain activity and heart patterns in people who have had a stroke and compares them to healthy adults. Researchers use special head sensors and heart monitors to measure differences. The goal is to better understand how stroke changes the brain and heart. No t…

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This study will collect brain scans from over 10,000 healthy people in China to create standard brain charts. These charts will show what a normal brain looks like at different ages. Doctors can then compare a patient's brain scan to these charts to help diagnose diseases like mu…

This observational study is testing whether a new digital imaging analysis can more accurately predict stroke risk in 400 adults with narrowed brain arteries (50-99% blockage). Participants undergo standard angiography, and researchers use a computer method to measure blood flow …

This study is testing whether a device that gently stimulates a nerve in the ear is safe and tolerable for healthy children. Ten children will receive a single 30-minute session while their heart rate, oxygen levels, and brain waves are monitored. The goal is to learn how the sti…

This study looks at how safe and effective newer blood thinners (NOACs) are for Korean adults with atrial fibrillation, a heart rhythm problem that raises stroke risk. Researchers will track about 1,000 patients for strokes, bleeding, and heart events. The goal is to better under…

This study looks at blood stem cells (called EPCs) in people with and without diabetes to see if they work differently. Researchers want to know if these cells can predict diabetic retinopathy, an eye disease that can cause vision loss. The study involves 78 adults, including 39 …

This study looks at how nerve reflexes in the thigh muscle affect walking in people who have had a stroke and have a stiff-knee gait. Researchers will use mild electrical stimulation to measure reflex activity while participants walk. The goal is to better understand why some str…

This study looks at how headaches, especially migraines, affect the work and daily life of Libbs employees. Researchers will analyze data already collected from over 1,300 workers through a health app. No new treatments or tests are given—the goal is to understand headache patter…

This study looks at how people who have had a stroke use healthcare services over the long term. Researchers will review medical records of about 40,000 patients and interview 240 survivors to understand their needs and experiences. The goal is to find patterns and gaps in care, …

This study aimed to compare two surgical systems, UNITY VCS and CONSTELLATION, for treating various eye conditions like macular holes and retinal detachment. It was designed for adults needing vitreoretinal surgery. However, the trial was withdrawn before enrolling any participan…

This study tests a new therapy program called REAP for stroke survivors in Bangladesh. The program helps people regain skills, educates families, adapts tasks, and promotes participation in daily life. Six adults who had a stroke 3-24 months ago will try the program to see if it …

This study is testing whether rehabilitation that combines physical and mental exercises (called dual-task training) can help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will design and try out different dual-task strategies in small gr…

This study looks at 250 stroke patients to understand why some arrive late at the hospital. Researchers use a questionnaire, mapping tools, and brain scans to find social, transport, and knowledge barriers. A machine learning model will try to predict who is at risk for delay, wi…

This study collects blood and urine samples from 500 people with rare brain vessel diseases, such as CADASIL and moya-moya. Researchers aim to find biomarkers that could improve care or identify new treatment targets. Participants are already part of an existing rare disease coho…

This study looks at how the brain's visual system changes in the year after a stroke that damages the vision center. Researchers will measure vision and brain structure over time, and give participants a home-based computer training program that asks them to detect moving dots. T…

This study looks at how often a common heart side effect (first-degree atrioventricular block) occurs when verapamil is used at high doses to prevent cluster headaches. Researchers will monitor 60 patients starting or already on verapamil, using ECGs and blood tests. The goal is …

This study tested a new device that measures blood flow, pressure, and temperature inside the brain, while also draining fluid. It was designed for patients with serious brain injuries who already need standard monitoring. Only one person took part, and the goal was to see if the…

This observational study is tracking 1,000 patients with stable atrial tachycardia to see how well different rhythm control treatments work over the long term. Researchers are focusing on serious outcomes like death, stroke, and heart-related hospital stays. The goal is to gather…

This study looks at whether a structured care plan can help people who had a brain hemorrhage (intracerebral hemorrhage) start moving earlier and more safely. About 198 participants will be guided through a step-by-step mobility program while their heart, breathing, and brain sta…

This study looks at whether a lighter sedation (sedoanalgesia) or full general anesthesia leads to better early recovery in people having emergency clot removal after a stroke. Researchers will track 62 patients' neurological scores and vital signs during and after the procedure.…

This study aimed to see if personalizing the dose of a gentle brain stimulation technique called tDCS could make it work better for improving movement. It planned to include healthy people and stroke survivors, but was withdrawn before anyone joined. No results are available.

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring them for delayed effects on cancer, dementia, disability, and death. The goal is to see if aspirin has any long-term benefits or risks years after stopping the …

This study offers free vision screenings to underserved adults over 40 living in affordable housing in Harlem and Washington Heights. The goal is to find eye problems like glaucoma, cataracts, and diabetic retinopathy early and connect people with follow-up care. About 749 partic…