Breakthrough trial aims to prevent lung damage in tiniest newborns

NCT ID NCT03253263

Ongoing Prevention Sponsor: OHB Neonatology Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 2 times

Summary

This study tests an investigational drug called OHB-607 to see if it can prevent bronchopulmonary dysplasia (BPD), a serious chronic lung disease, in extremely premature infants. About 338 babies will be randomly assigned to receive either the drug or standard care. The goal is to reduce severe lung problems and help babies breathe on their own sooner.

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Conditions

The condition(s) this trial relates to.

bronchopulmonary dysplasia retinopathy of prematurity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHOPULMONARY DYSPLASIA CHRONIC LUNG DISEASE OF PREMATURITY INTRAVENTRICULAR HEMORRHAGE RETINOPATHY OF PREMATURITY (ROP)

Contacts and locations

Locations

Academisch Medisch Centrum Amsterdam

Amsterdam-Zuidoost, North Holland, 1105 AZ, Netherlands
Arkansas Children's Hospital

Little Rock, Arkansas, 72202-3500, United States
Ashford and St. Peter's Hospitals NHS Trust - St. Peter's Hospital

Chertsey, Surrey, KT16 0PZ, United Kingdom
Azienda Ospedaliera Di Padova

Padova, Veneto, 35128, Italy
Azienda Ospedaliero-Universitaria Careggi SOD Neonatologia e Terapia Intensiva Neonatale

Florence, 50134, Italy
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Centro Hospitalar Lisboa

Lisbon, 1649-035, Portugal
Centro Materno Infantil do Norte - Centro Hospital Universitario do Porto, E.P.E.

Porto, 4050-651, Portugal
Chelsea and Westminster NHS Trust

London, SW3 6JJ, United Kingdom
Children's Hospital of Orange County

California City, California, 92868, United States
Children's Minnesota - Children's Hospital and Clinics

Saint Paul, Minnesota, 55102, United States
Children's Minnesota - Children's Hospital and Clinics - St. Paul

Saint Paul, Minnesota, 55102, United States
Cork University Maternity Hospital

Cork, Wilton, T12YE02, Ireland
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Lombardy, 20122, Italy
Hospital Garcia de Orta

Almada, 2801-951, Portugal
Hospital General Universitario Dr. Balmis

Alicante, 03010, Spain
Istituto Giannina Gaslini-Istituto Pediatrico di Ricovero e

Genova, 16147, Italy
Jackson Memorial Hospital

Miami, Florida, 33136-1005, United States
Klinikum Nürnberg

Nuremberg, 90479, Germany
Kurashiki Central Hospital

Kurashiki-shi, Okayama-ken, 710-0052, Japan
Liverpool Women's Hospital - PPDS

Liverpool, L69 3BX, United Kingdom
Maastricht University Medical Center

Maastricht, Limburg, 6229 HX, Netherlands
Maria Fareri Children's Hospital

Valhalla, New York, 10595, United States
Mater Misericordiae Limited

South Brisbane, Qld 4101, Australia
Maternidade Alfredo da Costa

Lisbon, 1069-089, Portugal
Medical University of South Carolina Children Hospital

Charleston, South Carolina, 29425-8908, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601-1078, United States
Nagano Children's Hospital

Azumino, Nagano, 399-8205, Japan
National Center for Child Health and Development

Tokyo, 157-8535, Japan
Norfolk and Norwich University Hospital

Norwich, Norfolk, NR4 7UY, United Kingdom
Ochsner Baptist Medical Center

New Orleans, Louisiana, 70115, United States
Oklahoma Children's Hospital - PIN

Oklahoma City, Oklahoma, 73104, United States
Osaka Women's and Children's Hospital

Izumi, Ôsaka, 594-1101, Japan
Oulun Yliopistollinen Sairaala

Oulu, 90220, Finland
Presidio Ospedaliero Di Treviso Ca' Foncello

Treviso, 31100, Italy
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Royal Hospital for Women

Randwick, New South Wales, 2031, Australia
Royal Women's Hospital

Parkville, 3052, Australia
Sainte Justine Hospital

Montreal, Quebec, Canada
Saitama Medical Center

Kawagoe-shi, Saitama, 350-8550, Japan
Saitama Prefectural Children's Medical Center

Saitama, Saitama, 330-8777, Japan
Showa Medical University Hospital

Tokyo, 142-8666, Japan
Skanes Universitetssjukhus

Lund, SE-22185, Sweden
St. Mary's Hospital

Manchester, M13 9WL, United Kingdom
Tampa General Hospital

Tampa, Florida, 33606-3571, United States
Texas Children's Hospital

Houston, Texas, 77030, United States
Tokyo Metropolitan Children's Medical Center

Tokyo, 183-8561, Japan
Tufts Medical Center

Boston, Massachusetts, 02111-1553, United States
US Davis

Sacramento, California, 95817, United States
UT Health Science Center

San Antonio, Texas, 78229, United States
UVA Children's Hospital

Charlottesville, Virginia, 22903, United States
Universitatsklinikum Leipzig

Leipzig, Saxony, 04103, Germany
University Hospital Coventry

Coventry, CV2 2DX, United Kingdom
University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72202-3500, United States
University of Cambridge

Cambridge, CB2 0QQ, United Kingdom
University of Illinois at Chicago

Chicago, Illinois, 60612, United States
University of Louisville Hospital

Louisville, Kentucky, 40202, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216-4500, United States
University of Rochester

Rochester, New York, 14627, United States
Virginia Commonwealth University - Children's Hospital of Richmond at VCU

Richmond, Virginia, 23298-5075, United States
Westmead Hospital

Westmead, New South Wales, NSW 2145, Australia
Wilhelmina Children Hospital-University Medical Center Utrecht

Utrecht, 3584 EA, Netherlands

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