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Early therapy may rewire motor development in premature infants

NCT ID NCT05568264

Ongoing Disease control Sponsor: Shirley Ryan AbilityLab Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether starting physical therapy early—while infants are still in the NICU and continuing until 12 months corrected age—can improve motor function and reduce the severity of motor delays in babies at high risk due to premature birth, brain injury, or other conditions. Infants in the intervention group receive up to two extra therapist visits per week, plus caregiver-guided activities, compared to standard care. The study measures motor skills at 12 months and also checks for earlier improvements and caregiver well-being.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Physical therapy intervention
What this could lead to
If effective, this early intervention could improve motor outcomes and reduce disability in infants at high risk for motor delays.
What could go wrong
The trial is early and may not show a significant benefit. The intervention requires caregiver commitment, and results may not apply to all infants.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia bronchopulmonary dysplasia perinatal asphyxia Premature Birth Psychomotor Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHOPULMONARY DYSPLASIA HYPOXIC-ISCHEMIC ENCEPHALOPATHY INTRAVENTRICULAR HEMORRHAGE MOTOR DELAY PREMATURE BIRTH

Contacts and locations

Locations

  • Ann & Robert H. Lurie Children's Hospital of Chicago

    Chicago, Illinois, 60611, United States

  • Children's Hospital at the University of Illinois

    Chicago, Illinois, 60612, United States

  • Northwestern Medicine Prentice Children's Hospital

    Chicago, Illinois, 60611, United States

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