HYPOXIC-ISCHEMIC ENCEPHALOPATHY

This study tests whether adding melatonin to standard cooling treatment can improve brain outcomes in newborns with hypoxic-ischemic encephalopathy (HIE), a serious birth complication. About 70 full-term infants will receive different doses of melatonin to find the safest and mos…

This study tests a new medicine called RLS-0071 in 70 newborns who have brain injury from not getting enough oxygen at birth. The babies also receive standard cooling therapy. The goal is to see if the drug is safe and can reduce brain damage and long-term problems like disabilit…

This study tests a drug called sovateltide in 40 newborns with brain injury from lack of oxygen at birth. The drug aims to help the brain repair itself and reduce the risk of death or long-term disability. Current standard treatment (cooling) has limited success, so researchers h…

This study looks at how to best give hydrocortisone to newborns with low blood pressure who are being cooled for brain injury caused by lack of oxygen at birth. About 50 full-term babies will receive the drug while doctors monitor their blood pressure and drug levels. The goal is…

This study tests whether higher doses of the seizure drug levetiracetam can safely control seizures in newborns. About 133 full-term infants with seizures or at risk for them will receive the medicine and be monitored with continuous EEG. The goal is to find the best dose that st…

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like autism, cerebral palsy, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen around birth. All babies are receiving standard cooling therapy. The goal is to find the right dose and check for safety. 16 newborns will…

This study watches how different types of anesthesia change blood flow and oxygen use in the brains of children having an MRI. Up to 1,000 kids from birth to 18 years old will take part. The goal is to learn more, not to test a new treatment.

This study follows 130 patients with severe brain injuries (from stroke, trauma, or lack of oxygen) who are in a coma or minimally conscious state. Researchers will use brain scans, EEGs, and other tests to find clues that might predict if and when a patient will regain conscious…

This study offers genome sequencing to 25 newborns diagnosed with hypoxic-ischemic encephalopathy (HIE) who are receiving cooling therapy. Researchers want to find out how often genetic conditions contribute to HIE. The goal is to better understand which babies might benefit from…