HYPOXIC ISCHEMIC ENCEPHALOPATHY

This early-phase study tests whether adding melatonin to standard cooling therapy can improve brain outcomes in newborns with hypoxic-ischemic encephalopathy (HIE), a condition caused by oxygen loss at birth. About 70 full-term infants will receive different doses of melatonin to…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study tests a drug called RLS-0071 in newborns who have brain damage from lack of oxygen during birth. The babies also receive standard cooling therapy. The goal is to see if the drug is safe and may help reduce brain injury. About 70 babies will take part, and they will be …

This study tests a drug called sovateltide in newborns with brain injury from lack of oxygen at birth (hypoxic-ischemic encephalopathy). The drug aims to help the brain repair itself. About 40 full-term babies will receive either sovateltide or a placebo, along with standard cool…

This study tests whether early physiotherapy, taught to parents, can improve movement and development in babies at risk for problems like cerebral palsy. Fifty infants from the NICU will be randomly assigned to get either the special program or standard care. Researchers will mea…

This study is testing a new way to detect motor delays in infants using a special play mat with sensors and a smart toy. Researchers will watch how babies move and interact with the toy, then use AI to spot early signs of disability. The goal is to create an easy, objective tool …

This study tests whether a higher-than-usual dose of the seizure medicine levetiracetam can safely stop seizures in newborns. About 133 full-term infants with seizures will first receive a standard dose, and if seizures continue, they will be randomly assigned to get either a hig…

This study looks at giving hydrocortisone, a steroid, to newborns with brain injury from lack of oxygen who are being cooled and have low blood pressure. Researchers want to find the best dose for each baby by measuring steroid levels in the blood. The goal is to safely raise blo…

This study looks at whether simple, non-invasive eye tests can help predict brain development in newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. Researchers will measure eye function using visual evoked potential (VEP) and ele…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like cerebral palsy, autism, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This research study follows the cognitive development of infants, both healthy and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, thinking, and language skills. The goal is to better understand how thes…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This study offers genome sequencing to 25 newborns diagnosed with HIE (a severe brain condition from lack of oxygen at birth) who are receiving cooling therapy. Researchers want to find out how often genetic changes cause or contribute to HIE. The goal is to help doctors decide w…

This study follows 130 patients with disorders of consciousness after stroke, traumatic brain injury, or oxygen deprivation. Researchers will use brain scans, electrical tests, and regular check-ups to find factors that might predict if and when patients regain consciousness. The…

This study looks at how blood flows in the brains of children who have been on ECMO, a machine that helps the heart and lungs. Researchers will use MRI scans and computer models to compare two ways of repairing the carotid artery after ECMO is removed. The goal is to understand w…