Cooling time trial for kids after heart stopping: could longer be better?

NCT ID NCT05376267

Recruiting now Disease control Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Therapeutic hypothermia (controlled body cooling)
What this could lead to: If it works, this could identify the optimal cooling duration to improve brain function and survival in children after cardiac arrest.
What could go wrong: This is an early-phase trial with no definitive results yet. The optimal duration may not improve outcomes, and longer cooling could carry risks like infection or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest Coma Hypothermia Out-of-Hospital Cardiac Arrest perinatal asphyxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST, OUT-OF-HOSPITAL HYPOTHERMIA, INDUCED HYPOXIA-ISCHEMIA, BRAIN

Contacts and locations

Locations

Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
American Family Children's Hospital
RECRUITING

Madison, Wisconsin, 53705, United States
Ann & Robert Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Banner University Medical Center - Tucson
ACTIVE_NOT_RECRUITING

Tucson, Arizona, 85719, United States
Birmingham Children's Hospital, United Kingdom
RECRUITING

Birmingham, United Kingdom
Bristol Royal Hospital for Children
RECRUITING

Bristol, Bristol, BS2 8BJ, United Kingdom
Children's Hospital Medical Center of Akron
RECRUITING

Akron, Ohio, 44308, United States
Children's Hospital of Illinois
RECRUITING

Peoria, Illinois, 61637, United States
Children's Hospital of Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital of Michigan
RECRUITING

Detroit, Michigan, 48201, United States
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868-4203, United States
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh (UPMC)
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Children's Medical Center of Dallas
RECRUITING

Dallas, Texas, 75235, United States
Children's Memorial Hermann Hospital
RECRUITING

Houston, Texas, 77030, United States
Children's Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Cincinnati Children's Hospital
RECRUITING

Cincinnati, Ohio, 45229, United States
Cohen Children's Medical Center of NY / Northwell Health
RECRUITING

New Hyde Park, New York, 11040, United States
Comer Children's Hospital, University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
Dayton Children's Hospital
RECRUITING

Dayton, Ohio, 45404, United States
Evelina London Children's Hospital
RECRUITING

London, London, SE17EH, United Kingdom
Gold Coast University Hospital
RECRUITING

Southport, Queensland, Australia
Johns Hopkins All Children's Hospital
RECRUITING

St. Petersburg, Florida, 33701, United States
Johns Hopkins Medicine Children's Center
RECRUITING

Baltimore, Maryland, 21287, United States
MassGeneral Hospital for Children
RECRUITING

Boston, Massachusetts, 02114, United States
Memorial Health - Miller Children's and Women's Hospital of Long Beach
RECRUITING

Long Beach, California, 90806-1701, United States
Monash Medical Centre
RECRUITING

Clayton, Victoria, 3168, Australia
Montefiore Einstein Hospital Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Mount Sinai Icahn / Kravis Children's Hospital
RECRUITING

New York, New York, 10029, United States
Ohio State University / Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Oregon Health & Science University Doernbecher Children's Hospital
RECRUITING

Portland, Oregon, 97239, United States
Penn State University / Penn State Children's Hospital
RECRUITING

Hershey, Pennsylvania, 17033, United States
Perth Children's Hospital
RECRUITING

Nedlands, Western Australia, Australia
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Primary Children's Hospital, University of Utah School of Medicine
WITHDRAWN

Salt Lake City, Utah, 84108, United States
Queensland Children's Hospital
RECRUITING

Brisbane, Queensland, 4101, Australia
Riley Children's Health
RECRUITING

Indianapolis, Indiana, 46202, United States
Royal Children's Hospital
RECRUITING

Parkville, Victoria, 3052, Australia
Stanford
RECRUITING

Santa Clara, California, 95050, United States
Starship Children's Hospital
RECRUITING

Grafton, Auckland, 1142, New Zealand
Texas Children's Hospital, Baylor
RECRUITING

Houston, Texas, 77030, United States
The Hospital for Sick Children
RECRUITING

Toronto, Ontario, Canada
The University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599-7220, United States
The University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Townsville University Hospital
RECRUITING

Douglas, Queensland, Australia
University of Alabama at Birmingham / Children's of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States
University of Buffalo / Oishei Children's Hospital
RECRUITING

Buffalo, New York, 14203, United States
University of California - Oakland / UCSF Benoiff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States
University of California - San Francisco (UCSF) Benioff Children's Hospital San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of California Los Angeles (UCLA) Mattel Children's Hospital
RECRUITING

Los Angeles, California, 90095, United States
University of California, Davis
RECRUITING

Sacramento, California, 95817, United States
University of Florida (UF) Health Shands Children's Hospital
RECRUITING

Gainesville, Florida, 32610-0296, United States
University of Iowa, Carver College of Medicine
RECRUITING

Iowa City, Iowa, 52242, United States
University of Maryland Children's Hospital
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami
RECRUITING

Miami, Florida, 33124, United States
University of Michigan CS Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Minnesota Fairview Masonic Children's Hospital
WITHDRAWN

Minneapolis, Minnesota, 55454, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68114, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642-8667, United States
University of Tennesses Health Center / Le Bonheur Children's
RECRUITING

Memphis, Tennessee, 38104, United States
Washington University / St. Louis Children's Hospital
RECRUITING

St Louis, Missouri, 63110, United States
Women's and Children's Hospital
RECRUITING

North Adelaide, South Australia, 5006, Australia

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