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Brain wave battle: deeper suppression may halt post-arrest seizures

NCT ID NCT05851391

Recruiting now Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppressing seizure activity. Thirty adults in intensive care will be randomly assigned to one of two EEG-guided anesthesia targets, and researchers will track how quickly seizures return.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
intravenous anesthesia titrated to burst suppression or seizure suppression on EEG
What this could lead to
If successful, this could establish a better way to stop dangerous seizures after cardiac arrest, potentially improving survival and brain recovery.
What could go wrong
This is a small, early-phase trial with only 30 participants, so results may not apply broadly. Deep anesthesia carries risks like low blood pressure and longer sedation.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest new-onset refractory status epilepticus perinatal asphyxia Status Epilepticus visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANOXIA-ISCHEMIA, CEREBRAL ANOXIC-ISCHEMIC ENCEPHALOPATHY HEART ARREST HYPOXIA-ISCHEMIA, BRAIN REFRACTORY STATUS EPILEPTICUS SEIZURES STATUS EPILEPTICUS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Zuckerberg San Francisco General Hospital

    RECRUITING

    San Francisco, California, 94110, United States

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