SEIZURES

This study compares taking the seizure drug levetiracetam for a short time versus the usual 2-3 years in people with brain tumors who have been seizure-free for 6 months. The goal is to see if stopping earlier can reduce side effects like drowsiness and coordination problems with…

This study tests if levetiracetam, a seizure medication, can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and poss…

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive usual care. The goal i…

This study aims to make it easier for paramedics to stop seizures in children by using age-based doses of the medicine midazolam instead of calculating doses based on weight. About 6,700 children who are actively seizing when paramedics arrive will be included. The goal is to see…

This study tests a non-invasive technique called pulsed low-intensity focused ultrasound (PLIFU) to reduce seizure activity in people with a severe, ongoing seizure condition called status epilepticus that hasn't improved with standard medications. Ten participants in the ICU wil…

This study is tracking 1,400 newborns in China who have had a seizure to find out how common it is and how it affects their development. Doctors will use EEG to record brain activity and check the babies' progress over time. The goal is to learn more about seizures in newborns, n…

This study looks at what causes oxygen toxicity in scuba divers. Researchers want to see how things like breathing muscle training, lack of sleep, certain medications, and carbon dioxide affect risk. 62 healthy divers aged 18-45 will exercise underwater and in dry conditions to m…

This study looks at the genes of 2,000 newborns and infants who have seizures within their first year of life. By understanding their genetic makeup, doctors hope to find better, personalized treatments. The goal is to see which gene changes are common and how well different trea…

This study looks at how scopolamine, a drug that affects memory, changes brain activity in people with epilepsy who already have electrodes implanted for seizure monitoring. About 60 participants will do memory tasks after receiving either the drug or a saltwater solution, and re…

This study aims to find genetic heart problems that might explain why some people with epilepsy die suddenly. Researchers will test 600 adults aged 18-50 with epilepsy, seizures, or related events, plus their blood relatives. They use advanced gene sequencing to look for known he…

This study aims to understand how the brain creates the feeling of wanting to move. Researchers will use safe, non-invasive techniques like brain stimulation and EEG to measure brain activity in 30 people—both healthy volunteers and patients with psychogenic movement disorders or…

This study is screening up to 1,000 people aged 8 and older who have epilepsy that doesn't respond well to medication. The goal is to better understand these hard-to-control seizures and find new ways to treat them. Participants will undergo various tests like brain scans and EEG…

This study is testing a small, ear-worn device that can detect and predict seizures in people with epilepsy. About 40 adults staying in a hospital epilepsy monitoring unit will wear the device while their brain activity is recorded with standard equipment. The goal is to see how …

This study is tracking up to 1,000 people with certain genetic changes that affect brain development. Researchers will collect medical records, school reports, and do tests on behavior, movement, and sleep. The goal is to better understand these conditions, not to test a new trea…