SEIZURES

This study compares taking the seizure drug levetiracetam for a short time versus the usual 2-3 years in people with brain tumors who have been seizure-free for 6 months. The goal is to see if stopping earlier can reduce side effects like drowsiness and coordination problems with…

This study tests if levetiracetam, a seizure medication, can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and poss…

This study tests whether the seizure drug levetiracetam (Keppra) can prevent first-time seizures in people with brain metastases located in the motor cortex. About 150 adults who have never had a seizure will be randomly assigned to take the drug or receive usual care. The goal i…

This study tests a simpler way for paramedics to give seizure medicine to children. Instead of calculating a dose based on weight, paramedics will use the child's age to pick one of four pre-set doses and give it as a shot or nasal spray. The goal is to see if this stops seizures…

This study tests a non-invasive technique called pulsed low-intensity focused ultrasound (PLIFU) to reduce seizure activity in people with a severe, ongoing seizure condition called status epilepticus that hasn't improved with standard medications. Ten participants in the ICU wil…

This study aims to find out how often newborns (0–28 days old) experience seizures for the first time. Researchers will use EEG to record brain activity and follow the babies' development over time. The study involves 1,400 participants across multiple hospitals in China and is p…

This study is testing a small, ear-worn device that can detect and predict seizures in people with epilepsy. About 40 adults staying in a hospital epilepsy monitoring unit will wear the device while their brain activity is recorded with standard equipment. The goal is to see how …

This study looks at what causes oxygen toxicity in scuba divers. Researchers want to see how breathing muscle training, lack of sleep, certain medications, and carbon dioxide affect risk. 62 healthy divers aged 18-45 will exercise underwater and in dry conditions while their brea…

This study aims to understand how the brain creates the feeling of wanting to move. Researchers will use safe, non-invasive techniques like brain stimulation and EEG to measure brain activity in 30 people—both healthy volunteers and patients with psychogenic movement disorders or…

This study looks at how scopolamine, a drug that can cause memory problems, changes brain activity during memory tasks. About 60 adults with epilepsy who are already having brain surgery for seizure monitoring will take part. They will receive either scopolamine or a saltwater pl…

This study aims to learn more about epilepsy, especially in people whose seizures don't improve with medication. Researchers will screen up to 1,000 adults and children aged 8 and older using tests like EEGs, MRIs, and memory assessments. The goal is to better understand these se…

This study is tracking up to 1,000 people with certain genetic changes that affect brain development. Researchers will collect medical records, school reports, and do tests on behavior, movement, and sleep. The goal is to better understand these conditions, not to test a new trea…

This study is looking for genetic heart problems in people with epilepsy that might raise their risk of sudden unexpected death. Researchers will test DNA from 600 adults and their relatives to find known heart-related gene changes. The goal is to better understand why some epile…

This study looks at the genes of 2000 newborns and infants who have seizures within their first year of life. Researchers want to find which gene changes are common and how they affect treatment. The goal is to use this information to choose more effective, personalized treatment…