Hidden heart genes may trigger sudden death in epilepsy patients

NCT ID NCT02824822

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study from Mayo Clinic looks for genetic heart conditions in people with epilepsy that might raise the risk of sudden unexpected death (SUDEP). Researchers will analyze DNA from 600 adults aged 18-50 with epilepsy or related symptoms, plus their blood relatives. The goal is to find inherited heart rhythm disorders that could be silently contributing to fatal seizures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help identify epilepsy patients at highest risk for sudden unexpected death, potentially leading to targeted monitoring or preventive strategies.
What could go wrong: This is an observational genetic study, not a treatment trial. It may not find clear genetic links, and any findings would need further research before changing clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiomyopathy Channelopathies Death, Sudden, Cardiac epilepsy long QT syndrome Polymorphic Catecholaminergic Ventricular Tachycardia Sudden Unexpected Death in Epilepsy Syncope syncope, familial vasovagal visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOMYOPATHIES CHANNELOPATHY EPILEPSY SEIZURES SYNCOPE

Contacts and locations

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Study contacts

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Email: •••••@•••••

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States

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