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Cooling duration may be key to brain recovery after cardiac arrest

NCT ID NCT04217551

Disease control Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This trial studies how long to cool the body after a cardiac arrest to protect the brain. It includes adults who are in a coma after being resuscitated from an out-of-hospital cardiac arrest. Participants are cooled to a target temperature and then rewarmed slowly, with different groups receiving different cooling durations. The goal is to find the optimal cooling time that leads to the best neurological outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
therapeutic hypothermia (controlled cooling and rewarming using a closed-loop temperature control device)
What this could lead to
If successful, this trial could identify the ideal cooling duration to maximize brain recovery and reduce disability in people who survive cardiac arrest.
What could go wrong
This is a large trial, but cooling therapy is already standard; the benefit of different durations may be small. Individual patient factors could also affect outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,158 people

The number who actually took part.

Started

May 2020

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Coma after resuscitation from out of hospital cardiac arrest * Cooled to \<34 deg C with 240 minutes of cardiac arrest * Definitive temperature control applied * Age ≥ 18 years * Informed consent from legal authorized representative (LAR) including intent to maintain life support for 96 hours * Enrollment within 6 hours of initiation of cooling Exclusion Criteria: * Hemodynamic instability * Pre-existing neurological disability or condition that confounds outcome determination * Pre-existing terminal illness, unlikely to survive to outcome determination * Planned early withdrawal of life support * Presumed sepsis as etiology of arrest * Prisoner

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest Coma Hypothermia Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest, out-of-hospital Hypothermia, induced Hypoxia-ischemia, brain

Contacts and locations

Locations

  • Adventist Health

    Portland, Oregon, 97216, United States

  • Advocate Christ Medical Center

    Oak Lawn, Illinois, 60453, United States

  • Banner University Medical Center

    Tucson, Arizona, 85719, United States

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • Brigham & Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Cooper University Hospital

    Camden, New Jersey, 08103, United States

  • DMC Sinai Grace Hospital

    Detroit, Michigan, 48235, United States

  • Denver Health Medical Center

    Denver, Colorado, 80204, United States

  • Detroit Receiving Hospital

    Detroit, Michigan, 48201, United States

  • Duke University Hospital

    Durham, North Carolina, 27710, United States

  • ECU Health Medical Center

    Greenville, North Carolina, 27834, United States

  • Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • Geisinger Medical Center

    Danville, Pennsylvania, 17822, United States

  • George Washington University Hospital

    Washington D.C., District of Columbia, 20037, United States

  • Grady Memorial Hospital

    Atlanta, Georgia, 30303, United States

  • Guthrie Robert Packer Hospital

    Sayre, Pennsylvania, 18840, United States

  • Harbor-UCLA Medical Center

    Torrance, California, 90502, United States

  • Harborview Medical Center

    Seattle, Washington, 98104, United States

  • Hennepin County Medical Center

    Minneapolis, Minnesota, 55415, United States

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Henry Ford Macomb Hospital

    Clinton Township, Michigan, 48038, United States

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • IU Health Methodist Hospital

    Indianapolis, Indiana, 46202, United States

  • Johns Hopkins Hospital

    Baltimore, Maryland, 21287, United States

  • M Health Fairview Southdale Hospital

    Edina, Minnesota, 55435, United States

  • Maine Medical Center

    Portland, Maine, 04102, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Memorial Hermann Hospital

    Houston, Texas, 77030, United States

  • Mercy St. Vincent Medical Center

    Toledo, Ohio, 43608, United States

  • MetroHealth Medical Center

    Cleveland, Ohio, 44109, United States

  • Montefiore Medical Center

    The Bronx, New York, 10467, United States

  • NYP Columbia University Medical Center

    New York, New York, 10032, United States

  • NYU Langone Health - Tisch Hospital

    New York, New York, 10016, United States

  • Northwestern Memorial Hospital

    Chicago, Illinois, 60611, United States

  • OSU East Hospital

    Columbus, Ohio, 43203, United States

  • OSU Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • Parkland Hospital

    Dallas, Texas, 75235, United States

  • Penn Presbyterian Medical Center

    Philadelphia, Pennsylvania, 19104, United States

  • Providence Regional Medical Center Everett

    Everett, Washington, 98201, United States

  • Regions Hospital

    Saint Paul, Minnesota, 55101, United States

  • Ronald Regan UCLA Medical Center

    Los Angeles, California, 90095, United States

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • SUNY Upstate Medical University

    Syracuse, New York, 13210, United States

  • South Shore University Hospital

    Bay Shore, New York, 11706, United States

  • Stanford University Medical Center

    Stanford, California, 94305, United States

  • Stony Brook University Hospital

    Stony Brook, New York, 11794, United States

  • Strong Memorial Hospital

    Rochester, New York, 14642, United States

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140, United States

  • The Mount Sinai Hospital

    New York, New York, 10029, United States

  • The Queen's Medical Center

    Honolulu, Hawaii, 96813, United States

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • UC Davis Medical Center

    Sacramento, California, 95817, United States

  • UC San Diego Medical Center - Hillcrest

    San Diego, California, 92103, United States

  • UF Health Shands Hospital

    Gainesville, Florida, 32608, United States

  • UPMC Harrisburg

    Harrisburg, Pennsylvania, 17101, United States

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Alabama Hospital

    Birmingham, Alabama, 35233, United States

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University of Cincinnati

    Cincinnati, Ohio, 45220, United States

  • University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • University of Illinois-Chicago Hosptial

    Chicago, Illinois, 60612, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of Kentucky Hospital

    Lexington, Kentucky, 40536, United States

  • University of Maryland Medical Center

    Baltimore, Maryland, 21201, United States

  • University of Michigan Hospital

    Ann Arbor, Michigan, 48109, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • University of New Mexico

    Albuquerque, New Mexico, 87106, United States

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Utah Hospital

    Salt Lake City, Utah, 84132, United States

  • University of Virginia Medical Center

    Charlottesville, Virginia, 22903, United States

  • VCU Medical Center

    Richmond, Virginia, 23298, United States

  • Wake Forest Baptist Medical Center

    Winston-Salem, North Carolina, 27157, United States

  • William Beaumont Hospital

    Royal Oak, Michigan, 48073, United States

  • Yale New Haven Hospital

    New Haven, Connecticut, 06510, United States

  • Zuckerberg San Francisco General Hospital

    San Francisco, California, 94110, United States

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