Cooling duration may be key to brain recovery after cardiac arrest

NCT ID NCT04217551

Completed Disease control Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This trial studies how long to cool the body after a cardiac arrest to protect the brain. It includes adults who are in a coma after being resuscitated from an out-of-hospital cardiac arrest. Participants are cooled to a target temperature and then rewarmed slowly, with different groups receiving different cooling durations. The goal is to find the optimal cooling time that leads to the best neurological outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: therapeutic hypothermia (controlled cooling and rewarming using a closed-loop temperature control device)
What this could lead to: If successful, this trial could identify the ideal cooling duration to maximize brain recovery and reduce disability in people who survive cardiac arrest.
What could go wrong: This is a large trial, but cooling therapy is already standard; the benefit of different durations may be small. Individual patient factors could also affect outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest Coma Hypothermia Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC ARREST, OUT-OF-HOSPITAL HYPOTHERMIA, INDUCED HYPOXIA-ISCHEMIA, BRAIN

Contacts and locations

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Locations

Adventist Health

Portland, Oregon, 97216, United States
Advocate Christ Medical Center

Oak Lawn, Illinois, 60453, United States
Banner University Medical Center

Tucson, Arizona, 85719, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Cooper University Hospital

Camden, New Jersey, 08103, United States
DMC Sinai Grace Hospital

Detroit, Michigan, 48235, United States
Denver Health Medical Center

Denver, Colorado, 80204, United States
Detroit Receiving Hospital

Detroit, Michigan, 48201, United States
Duke University Hospital

Durham, North Carolina, 27710, United States
ECU Health Medical Center

Greenville, North Carolina, 27834, United States
Froedtert Hospital

Milwaukee, Wisconsin, 53226, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
George Washington University Hospital

Washington D.C., District of Columbia, 20037, United States
Grady Memorial Hospital

Atlanta, Georgia, 30303, United States
Guthrie Robert Packer Hospital

Sayre, Pennsylvania, 18840, United States
Harbor-UCLA Medical Center

Torrance, California, 90502, United States
Harborview Medical Center

Seattle, Washington, 98104, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Macomb Hospital

Clinton Township, Michigan, 48038, United States
Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
IU Health Methodist Hospital

Indianapolis, Indiana, 46202, United States
Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States
M Health Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
Maine Medical Center

Portland, Maine, 04102, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Hermann Hospital

Houston, Texas, 77030, United States
Mercy St. Vincent Medical Center

Toledo, Ohio, 43608, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
NYP Columbia University Medical Center

New York, New York, 10032, United States
NYU Langone Health - Tisch Hospital

New York, New York, 10016, United States
Northwestern Memorial Hospital

Chicago, Illinois, 60611, United States
OSU East Hospital

Columbus, Ohio, 43203, United States
OSU Wexner Medical Center

Columbus, Ohio, 43210, United States
Parkland Hospital

Dallas, Texas, 75235, United States
Penn Presbyterian Medical Center

Philadelphia, Pennsylvania, 19104, United States
Providence Regional Medical Center Everett

Everett, Washington, 98201, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Ronald Regan UCLA Medical Center

Los Angeles, California, 90095, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
SUNY Upstate Medical University

Syracuse, New York, 13210, United States
South Shore University Hospital

Bay Shore, New York, 11706, United States
Stanford University Medical Center

Stanford, California, 94305, United States
Stony Brook University Hospital

Stony Brook, New York, 11794, United States
Strong Memorial Hospital

Rochester, New York, 14642, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The Mount Sinai Hospital

New York, New York, 10029, United States
The Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
UC Davis Medical Center

Sacramento, California, 95817, United States
UC San Diego Medical Center - Hillcrest

San Diego, California, 92103, United States
UF Health Shands Hospital

Gainesville, Florida, 32608, United States
UPMC Harrisburg

Harrisburg, Pennsylvania, 17101, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of Alabama Hospital

Birmingham, Alabama, 35233, United States
University of Chicago Medical Center

Chicago, Illinois, 60637, United States
University of Cincinnati

Cincinnati, Ohio, 45220, United States
University of Colorado Hospital

Aurora, Colorado, 80045, United States
University of Illinois-Chicago Hosptial

Chicago, Illinois, 60612, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Kentucky Hospital

Lexington, Kentucky, 40536, United States
University of Maryland Medical Center

Baltimore, Maryland, 21201, United States
University of Michigan Hospital

Ann Arbor, Michigan, 48109, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico

Albuquerque, New Mexico, 87106, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Utah Hospital

Salt Lake City, Utah, 84132, United States
University of Virginia Medical Center

Charlottesville, Virginia, 22903, United States
VCU Medical Center

Richmond, Virginia, 23298, United States
Wake Forest Baptist Medical Center

Winston-Salem, North Carolina, 27157, United States
William Beaumont Hospital

Royal Oak, Michigan, 48073, United States
Yale New Haven Hospital

New Haven, Connecticut, 06510, United States
Zuckerberg San Francisco General Hospital

San Francisco, California, 94110, United States

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