University Of Michigan

This study tests whether community members can be trained as health coaches to deliver the HealthyLifetime program, a virtual health coaching intervention designed to improve health behaviors and prevent functional decline in adults aged 30 and older with few chronic conditions. …

This study tests a program called MiWeigh that helps people with obesity and related conditions like diabetes or high blood pressure lose weight. Participants get a personalized plan from a doctor, access to a website, and weekly check-ins. The goal is to see if this approach lea…

This pilot study is testing whether combining cognitive behavioral therapy (CBT) with guided exercise can improve blood sugar control, reduce depression, and boost quality of life in Black men with type 2 diabetes. Eighty participants will receive 8 sessions of CBT, with half als…

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study tests a smartphone program called HeartSteps to help people with heart disease stay physically active after cardiac rehab. Sixty adults will wear a Fitbit and use the app for 3 months to see if it boosts their weekly exercise minutes. The goal is to learn how to best s…

The ATHENA Project is testing a mobile health program designed to help African American young adults (ages 18-30) better control their asthma. Participants use a web-based app, have video chats with an asthma nurse, receive text messages, and track physical activity. The study ai…

This early study tests whether small implants placed on nerves in the thigh can help people with above-knee amputations control a robotic leg more naturally and feel sensations from it. Three participants will undergo surgery to create regenerative nerve interfaces and have elect…

This study tests a flexible silicone tube that people insert into one nostril before sleep to keep their airway open. It's for adults with moderate to severe obstructive sleep apnea who cannot tolerate CPAP machines. Twenty participants will use the device for 30 days to see if i…

This study tests if dapagliflozin, a diabetes drug, can reduce heart and blood vessel risks in women who had high blood pressure during pregnancy. About 200 participants will take either the drug or a placebo daily for six months after delivery. The goal is to see if the drug imp…

This study looks at whether giving an extra dose of the antibiotic cefoxitin during appendix removal surgery can better prevent infections compared to the usual single dose before surgery. Researchers will measure antibiotic levels in blood, fat, and appendix tissue from 46 parti…

This study is testing whether a daily pill called Relugolix CT (Myfembree) can reduce pelvic pain, inflammation, and pain sensitivity in women with endometriosis. Researchers will measure changes in blood markers of inflammation and brain scans related to pain. The trial involves…

This study tests a program to help doctors safely reduce or stop thyroid hormone medication in adults aged 65 and older who are getting too much or don't need it. The goal is to prevent harm from overtreatment while keeping thyroid levels healthy. About 900 participants will take…

This study tests whether waiting a bit before surgically repairing bone damage around infected dental implants leads to better results than fixing it right away. Forty adults with peri-implantitis (gum infection around implants) will be randomly assigned to one of two surgical ap…

This expanded access program provides metreleptin (MyaLept) to patients with familial partial lipodystrophy who also have diabetes or very high triglycerides. Metreleptin is already approved for generalized lipodystrophy, but this program aims to help those with the partial form.…

This study tests a custom 3D-printed splint that holds open a child's collapsing airway. The splint is made of a material that the body absorbs over about five years. The trial includes 35 children with severe tracheobronchomalacia who need breathing support. Researchers will che…

This study looks at a special type of stitch (STRATAFIX) already approved by the FDA for closing wounds after brain or spine surgery. Researchers want to see if it helps wounds heal better and with fewer problems. About 160 adults having brain or spine surgery will take part. The…

This study follows 20 people who have already used a flexible silicone tube device (NPA-OSA) for obstructive sleep apnea. Participants will continue using the device at night for up to 12 months. Researchers will check if the device keeps working well by measuring sleep apnea eve…

This study tests whether giving a single dose of calcium gluconate before a cesarean delivery can reduce blood loss in women at high risk for heavy bleeding. Researchers will compare calcium gluconate to a placebo in 140 pregnant volunteers. The goal is to see if this simple, ine…

This phase 2 trial tests whether tirzepatide (Mounjaro), a drug already approved for diabetes and weight loss, can improve blood sugar and lower triglycerides in people with partial lipodystrophy—a rare condition where the body loses fat tissue. Researchers will compare tirzepati…

This study is testing whether a new laser-based imaging technique, called photoacoustic tomography (PAT), can help diagnose rheumatoid arthritis. Researchers will scan the finger joints of 113 adults—some with arthritis and some healthy—and compare PAT with MRI and ultrasound. Th…

This study enrolls 950 men with suspected but undiagnosed prostate cancer who are scheduled for a biopsy. Researchers will compare the accuracy of prostate MRI against a panel of blood and urine biomarkers (PCA3, PSA, TMPRSS2:ERG) in detecting clinically significant prostate canc…

This study compares a technology-enhanced eye exam to a standard optometric exam for detecting three leading causes of blindness: glaucoma, diabetic retinopathy, and cataracts. About 900 adults at a Federally Qualified Health Center will be randomly assigned to one of the two exa…

This study tests whether using a slower-flow bottle nipple for a few days helps babies drink less milk and develop healthier feeding patterns. Researchers will monitor 440 infants to see if the change affects how much they eat, their sucking behavior, and sleep. The goal is to fi…

This study tests whether a specific diet can change gut bacteria and help prevent another C. difficile infection in adults who have had one. Twenty participants will receive prepared meals and health counseling, then follow a similar diet for 6 more weeks. Researchers will track …

This study tests an online program called Store Safely that teaches rural families with children how to store firearms more safely. The program includes videos, facts, and a personalized action plan. Researchers will check if families lock up more guns after using the program. 60…

This study tests whether a concentrated grape powder, taken for three days before heart surgery, can prevent a common complication called post-operative atrial fibrillation (POAF). POAF is an irregular heartbeat thought to be triggered by inflammation after surgery. The trial wil…

This study tests an online program called Families in Balance Online, designed to help parents of 2- to 5-year-olds build healthy routines around meals, sleep, and screen time. About 300 families with low income will be randomly assigned to either this interactive program or a se…

This study compares two approaches to prevent delirium in older adults during a hospital stay. One is standard hospital care (HELP), and the other adds daily support from family members (FAM-HELP). Researchers will track 1,900 patients aged 70 and older to see if family involveme…

This study tests whether a personalized education and counseling program, called ComBaT Glaucoma, can encourage Black Americans at high risk for glaucoma to see an eye doctor regularly. The program is delivered through a community church setting. Researchers will track whether pa…

This study tests whether sodium nitrate, a natural salt, can prevent kidney injury caused by contrast dye used in heart and CT scans. Researchers will enroll 100 high-risk patients to see if the treatment is practical and effective. The goal is to find a simple, low-cost way to p…

This study tests a program called YES-IDEAS that aims to reduce violence and promote positive behaviors among middle school students. About 512 students in after-school programs in Michigan will take part. The program helps youth design community projects to build empowerment and…

This study tests whether a school-based program called READY to Stand can help prevent the commercial sexual exploitation of children (CSEC) among high school students. Over 3,200 teens in grades 9-12 from diverse urban schools will take part. The program includes videos, group d…

This study tests two digital programs to prevent or reduce alcohol misuse in teens aged 12-19 who have used alcohol in the past year. Participants receive a brief web program, and some also get 8 weeks of supportive text messages. Parents are encouraged to use a free app to guide…

This study compares three different diets to see which one best reduces bloating and other stomach symptoms in people with systemic sclerosis (scleroderma). Sixty participants will follow one of three diets for six weeks: a low-FODMAP diet, a diet that removes foods harmful to th…

This study tests whether a brief form of talk therapy, called Prolonged Exposure for Primary Care (PE-PC), can reduce PTSD symptoms in first responders and frontline healthcare workers. Participants receive 4-6 weekly 30-minute sessions either by telehealth or in person, delivere…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can improve visual and thinking abilities in people with posterior cortical atrophy (PCA), a rare condition often linked to Alzheimer's. Fifty participants will receive either real or sham stimulat…

This trial tests whether starting PTSD treatment with one type of talk therapy and then switching to another based on early progress leads to better symptom relief. About 430 adults receiving care at federally qualified health centers will take part. The study compares different …

This study tests a modular, powered leg brace (exoskeleton) designed to assist knee movement and reduce pain in people with knee osteoarthritis. The brace provides a small amount of torque to help the joint, potentially lowering muscle effort and painful loads on the knee. Resear…

This study looks at whether resistance training (like lifting weights) twice a week can improve blood vessel health, mood, sleep, and quality of life in women going through menopause. Researchers will compare a group that exercises with a group that only receives informational em…

This study tests whether using a bright light device for one hour each morning, combined with a consistent sleep schedule, can improve symptoms of fibromyalgia—a condition causing widespread pain and fatigue. Researchers at the University of Michigan are recruiting 390 adults wit…

Many people with Crohn's disease still have belly pain, bloating, or irregular bowel habits even when their disease is not active. This study tests whether a low dose of amitriptyline, a medication already used for irritable bowel syndrome, can safely reduce those symptoms. One h…

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Researchers aim to see if coaching improves pain, anxiety, and overall well-being. The trial is recruiting 468 veterans across the U.S.

This study tests a short, Zoom-based therapy called Brief Pain Reprocessing Therapy (BPRT) for veterans with chronic low back pain. About 47 veterans will try the program to see if it is acceptable, safe, and practical. The goal is to reduce pain and improve quality of life witho…

This study tests whether a type of talk therapy for insomnia, delivered via telemedicine, can improve sleep and reduce cannabis use in adults who have trouble sleeping and use cannabis regularly. 200 participants will be randomly assigned to either cognitive behavioral therapy fo…

This study tests a short behavioral treatment delivered over Zoom to help adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. The goal is to reduce pain, disability, and related issues like anxiety or depression. Participants will learn strategies to m…

This study tests whether a custom dental device called a palatal augmentation prosthesis (PAP), along with speech therapy, can improve how well people speak and swallow after surgery for small tongue cancers (T1/T2). Forty participants will be randomly assigned to receive the dev…

This study tests whether morning light therapy can improve sleep timing and reduce symptoms in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Sixty-eight adults with active IBD symptoms will either use a light therapy device at hom…

This small pilot study tests a special standing desk that gently moves, prompting people with Parkinson's to take small steps while standing. Five participants will use the desk for up to 12 sessions over 6 weeks. Researchers will measure walking speed, motor symptoms, and thinki…

This study compares two common ways to manage pain after surgery: NSAIDs (like ibuprofen) plus acetaminophen, or low-dose opioids (like oxycodone) plus acetaminophen. About 900 adults having gallbladder removal, hernia repair, or breast lump removal will be randomly assigned to o…

This study compares two approaches for older adults with knee osteoarthritis and insomnia: personalized exercise coaching alone versus exercise plus a digital insomnia treatment. Researchers want to see if adding sleep therapy leads to greater pain relief. The trial involves 288 …

This pilot study will test whether short, immersive virtual reality nature sessions can reduce depression, anxiety, and stress in adults with alcohol use disorder who are in an intensive outpatient program. Fifty participants will either receive standard care or add up to 12 VR n…

This study tests whether adding emotional regulation therapy (ERT) to standard low vision rehabilitation (LVR) helps people with inherited retinal diseases who feel anxious or distressed about their vision. About 180 participants will receive LVR, which includes free vision-enhan…

This study tests a program called SCOOP for older adults (60+) living in rural areas who have chronic pain and feel lonely. Participants watch short videos and have up to 7 weekly coaching sessions with a community health worker to learn pain management and social connection stra…

This study tests a special nasal airway device (ssNPA) in 40 children with weak throat muscles and obstructive sleep apnea, including those with Down syndrome. The device is designed to keep the airway open during sleep without needing surgery. Researchers will measure how well i…

This study tests whether a website called PainGuide, combined with a Fitbit, can help people with chronic low back pain. About 550 participants will use the online program and complete surveys over 24 to 52 weeks. The goal is to see if tailored digital coaching reduces how much p…

This study is testing whether a device that delivers mild electrical stimulation through the skin (called TEA) can help with chronic pain and depression in people with cirrhosis. Thirty participants will use the device at home twice daily for 8 weeks, or a sham version. The main …

This study compares two common ways to manage pain in children after they leave the hospital following surgery. About 900 kids having their tonsils, gallbladder, or knee scoped will be randomly assigned to receive either NSAIDs plus acetaminophen or low-dose opioids plus NSAIDs a…

This study tests if a gentle, non-invasive brain stimulation (tDCS) given for 20 minutes daily over 20 days can reduce migraine pain. About 60 people with chronic migraine will receive either real or sham stimulation, and 20 people with episodic migraine will be observed for comp…

This study compares two additional treatments for high tone pelvic floor dysfunction (HTPFD) when combined with standard pelvic floor physical therapy. Participants will either take a muscle relaxant medication (cyclobenzaprine) or use a vibrating pelvic floor massage wand. The g…

This study tests an online, 9-week program designed to help parents and caregivers of LGBTQ+ youth of color become more supportive and accepting. Researchers will enroll 180 youth (ages 14-25) and their caregivers to see if the program reduces depression, anxiety, drug use, and o…

This study tests if applying silver diamine fluoride (SDF) to children's molars affected by molar incisor hypomineralization (MIH) helps local anesthesia work better during fillings. Fifty children will receive either SDF or a placebo before dental work. The goal is to see if SDF…

This study explores whether using a virtual reality headset to experience nature scenes can help reduce depression in people with progressive multiple sclerosis. About 40 participants will use the Apple Vision Pro at home for short sessions over 8 weeks. The goal is to see if thi…

This study tests whether virtual reality (VR)-guided brain-gut behavioral therapy can help manage pain in hospitalized adults with inflammatory bowel disease (IBD). Researchers want to see if the approach is practical and acceptable to patients. About 40 participants will try the…

This study looks at whether a low sulfur diet can reduce ongoing symptoms like belly pain and diarrhea in people whose Crohn's disease is otherwise quiet. Twenty adults with Crohn's in remission will either follow a low sulfur diet or their usual diet for 8 weeks. Participants wo…

This pilot study from the University of Michigan is testing whether a non-invasive nerve stimulation device, used at home, can improve sexual arousal in women with female sexual dysfunction. Twenty-four participants will use the UCon patch system to stimulate the dorsal genital n…

This study looks at whether leaving a stent out after kidney stone surgery can reduce pain and the need for extra medical visits. About 184 adults with kidney or ureteral stones will be randomly assigned to either get a stent or not after their procedure. Researchers will track p…

This study looks at whether it is safe and less painful to skip placing a temporary tube (stent) after routine kidney stone removal. About 792 adults with small stones will either get a stent or not, and researchers will track pain and any unplanned doctor visits. The goal is to …

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests whether having a trained therapy dog present during a child's dental numbing injection can reduce anxiety and distress. About 25 children aged 4 to 12 will be randomly assigned to either have a therapy dog with them or receive standard care. Researchers will meas…

This study tests an online self-help program called Empower@Home for older adults with depression who have trouble walking. The program includes 9 online sessions, a workbook, and phone coaching from a trained staff member. Researchers will compare it to usual care in 64 particip…

This study is testing a digital mental health program called Empower@Home for homebound older adults (age 50+) with depression. The program includes online self-help sessions, a workbook, and phone coaching from trained staff. Researchers will compare it to usual care in 256 part…

This study tests whether simple, passive robotic devices can help people who have had a stroke regain arm and hand movement. Four participants will use the devices during reaching exercises, sometimes with electrical stimulation to activate muscles. The goal is to see if this app…

This study tests a tablet-based tool called the Epilepsy Visit Planner for adults with drug-resistant epilepsy. The tool helps patients set goals and share concerns before doctor visits. Researchers want to see if it improves communication and quality of life. About 152 participa…

This study tests a 6-month nurse-led health coaching program for 120 older adults who want to stay healthy and independent at home. Participants get personalized virtual coaching, health tracking tools, and monthly check-ins. The goal is to improve self-care, health habits, and q…

This study compares two treatments for abdominal pain in people with irritable bowel syndrome with constipation (IBS-C): a home-use device that delivers mild electrical stimulation (TEA) and the drug escitalopram (Lexapro). About 160 participants will be randomly assigned to one …

This study tests whether a 6-week program of non-weight bearing exercise can help diabetic foot ulcers heal faster than standard wound care alone. Forty adults with type 2 diabetes and a foot ulcer will be randomly assigned to exercise plus standard care or standard care only. Re…

This study tests whether a gentle, noninvasive electrical current applied to the scalp can improve speech fluency in adults who stutter. Researchers will give 80 participants three sessions of brain stimulation while they read aloud, then measure changes in brain activity and stu…

This study tests whether walking on a split-belt treadmill (where each leg moves at a different speed) can improve how the knee loads weight after ACL reconstruction. Nine people who had ACL surgery within the past 10 months will be randomly assigned to one of two training groups…

This study compares two common surgeries for ulnar neuropathy at the elbow: simple decompression and subcutaneous anterior transposition. Researchers will enroll 378 adults with confirmed ulnar nerve issues to see which surgery better improves hand function and reduces pain. Part…

This study looks at whether a person's genetic makeup can predict how well they respond to the heart failure drug metoprolol. Researchers will give the drug to 100 people with heart failure and track their heart function and drug levels. The goal is to see if a genetic score can …

This study at the University of Michigan is recruiting 500 incoming freshmen to understand why some people are more vulnerable to stress while others bounce back easily. Participants will use a mindfulness app called Maya for 6 weeks, wear a Fitbit for a year, and provide samples…

This study aims to create a smartphone system that sends personalized pain management tips to adults with multiple sclerosis or spinal cord injury who have chronic pain. Researchers will interview participants to understand their preferences for the content and timing of these no…

This study looks at whether certain proteins in the blood can help doctors monitor severe traumatic brain injury and predict who might benefit from hyperbaric oxygen therapy. Researchers will analyze blood samples from 150 patients already enrolled in a larger trial testing diffe…

This study aims to find a marker in stool or urine that can objectively measure whether people with Irritable Bowel Syndrome (IBS) are sticking to their prescribed diet. Researchers will enroll 94 adults with moderate-to-severe IBS and track their food intake and gut symptoms. Th…

This study looks at how an FDA-approved diabetes drug, Canagliflozin (Invokana), might protect the kidneys in people with type 2 diabetes. Twenty adults aged 18-80 with type 2 diabetes for at least 3 years will take the drug daily for 6 months. Researchers will use kidney biopsie…

This study is for people with rare kidney diseases like Minimal Change Disease, Focal Segmental Glomerulosclerosis, and Membranous Nephropathy. Researchers will collect health information and biological samples from 1,200 participants over many years. The goal is to better unders…

This study helps people with certain kidney diseases (like nephrotic syndrome and FSGS) find clinical trials that match their specific disease profile. Researchers analyze participants' molecular data to recommend targeted therapies in ongoing trials. The goal is to improve treat…

This study looks at how differences in personality, brain activity, and behavior may make some young adults more likely to use substances like cannabis. Researchers will track eye movements and brain scans in 294 people aged 18-22. No treatment or medication is involved—the goal …

This study looks at how a specific gene change (LRRK2 mutation) affects brain chemicals in people with Parkinson's disease. Researchers will compare 15 participants with the mutation to others without it using brain scans, thinking tests, and movement tests. The goal is to better…

This study looks at how the brain reacts to small electrical signals in people with epilepsy that doesn't get better with medication. Researchers will use special electrodes placed during brain surgery to record the brain's response. Only 5 participants will take part, all of who…

This study tests a technique called real-time fMRI neurofeedback, where people with depression learn to control brain activity by watching a visual pattern change in real time during an MRI scan. Researchers want to see if this can help regulate brain networks linked to depressio…

This study investigates how exercise affects the structure and function of fat tissue in adults aged 18-40 with obesity or metabolic syndrome. Participants are randomly assigned to either an exercise program or a sedentary control group. All undergo a 10% weight loss phase, then …

This study tests whether real-time brain scans (fMRI) can help young adults with anxiety learn to regulate their emotions better. Participants will practice reappraising negative thoughts while seeing their own brain activity. The goal is to understand which brain areas are invol…

This study looks at how doctors feel about using a new disposable activity monitor called VERABAND™ for people with chronic low back pain. About 360 clinicians and patients will take part. The goal is to see if doctors find it easy to use and if they would recommend it in their p…

This study follows 4,700 children whose mothers were given vouchers for free or discounted IUDs to prevent unintended pregnancies. Researchers want to see if preventing unplanned births improves children's school performance and family stability. The study is observational and do…

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may contribute to insulin resistance in adolescents. Researchers will collect blood samples and health information from 175 teens aged 14-18, including those wi…

This study looks at how difficult childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will use brain scans and memory tests to compare three groups: people with opioid use disorder on buprenorphine, people without the disor…

This study looks at whether reducing ultra-processed foods—like chips, soda, and fast food—causes withdrawal symptoms such as anger or anxiety. Researchers will monitor 210 adults with signs of food addiction as they follow a low-UP diet for a week, tracking cravings, stress, and…

This study looks at how pregnant women sleep, focusing on the positions they spend the most time in and how often they snore. About 500 women who are at least 28 weeks pregnant will use a sleep monitor at home. The goal is to learn more about sleep patterns during pregnancy and s…

This study tests whether a set of tools—like doctor education, decision aids, and financial incentives—can reduce unnecessary medical tests before low-risk surgeries such as breast lump removal, gallbladder removal, and hernia repair. Sixteen hospitals in Michigan will use these …

This study is testing whether a smartphone app can help people in Michigan on Medicaid who are recovering from both opioid and alcohol use disorders. The app uses rewards to encourage healthy behaviors. Researchers want to see if people find the app useful and easy to use, and if…

This study is collecting medical information and biological samples (like blood, urine, and kidney tissue) from 300 people with FSGS or MCD who have had or will have a kidney transplant. The goal is to build a research biobank called RESOLVE to help scientists study why these dis…

This study uses brain scans (fMRI) to compare brain activity when adults who stutter produce stuttered versus non-stuttered speech. Researchers aim to understand which brain circuits are involved. Fifty adults aged 18-65 who stutter will participate. This is not a treatment study…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study looks at whether having resident doctors meet former ICU patients they treated can reduce professional burnout and increase fulfillment. About 30 residents and patients will take part. Researchers will survey the doctors before and after the meeting and interview them …

This study looks at what happens inside your fat tissue when you lose weight with or without exercise. 68 adults with obesity will lose 10% of their body weight through diet, with some also doing moderate exercise. Researchers will measure insulin sensitivity, fat breakdown, and …

This small pilot study tests whether giving a one-time dose of vitamin K before surgery can safely lower the blood-thinning effect of warfarin, so patients can keep taking their regular medication without interruption. The study will enroll 20 adults who have been on warfarin for…

This study tests a decision support tool for adults with eosinophilic esophagitis (EoE). About 40 participants will use either the tool or general education before a clinic visit. Researchers want to see if the tool is helpful and easy to use, and if it improves treatment knowled…

This study is testing whether a combination of therapy (CBT) and a team of caring adults chosen by the teen can help Black adolescents who are thinking about suicide or have hurt themselves. The study will enroll 15 Black teens aged 12-17 and their chosen support people. Research…

This study looks at whether CT scans done for lung cancer screening can also help find COPD, a common lung disease in smokers. Researchers will review scans from 200 current or former smokers aged 50–80 who already had a CT scan as part of routine care. The goal is to see how man…

This study follows about 500 people with lipodystrophy (a rare condition where the body loses fat tissue) for 5 to 7 years. Researchers want to find out how often diabetes and very high blood fats (triglycerides) occur, and what health problems they cause. Participants visit once…

This study aims to understand how a modified-release diabetes drug called glipizide dissolves in the stomach and small intestine. Researchers will directly sample gut contents, blood, urine, and stool from 40 healthy volunteers after they take the drug. The goal is to improve lab…

This study compares two methods for getting rid of leftover opioid painkillers after surgery: a special pouch that deactivates the drugs, and a prepaid envelope to mail them back. Researchers will track which method more people actually use. The goal is to find a simple, effectiv…

This study tests whether a gentle, non-invasive brain stimulation technique can improve memory and brain function in older adults with mild cognitive impairment. Researchers will use brain scans to measure changes in brain activity and chemical levels. The goal is to understand h…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will use EEG and fMRI to measure brain activity and test a gentle brain stimulation technique called HD-tDCS. The goal is to understand pain processing…

This pilot study tests an AI system called PICTURE-Pediatric that alerts hospital staff when a child's condition might worsen in the next 24 hours. The system gives a score and sends notifications to doctors and nurses. The study will enroll 375 clinicians to see if they follow t…

This study compares cannabis users and non-users during wisdom tooth removal under IV sedation. Researchers will measure how much sedative medication is needed and track vital signs like heart rate and blood pressure. The goal is to understand if cannabis use changes how people r…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can improve hand movement in healthy older adults. Forty right-handed participants will receive either standard or personalized stimulation, plus brain scans. The goal is to see if customizing the …

This study is testing whether having groceries delivered can help low-income pregnant young women gain a healthy amount of weight and eat better. About 570 women in early pregnancy will take part. The goal is to learn if this simple support can improve health during pregnancy.

This study aims to make powered prosthetic legs for above-knee amputees move more naturally by using machine learning to model how healthy joints work. Researchers will test the new control system in 40 participants, including both able-bodied individuals and those with amputatio…

This study is collecting DNA and MRI data from 3,500 adults aged 40 to 85 to find genetic variations linked to rotator cuff tears. Researchers will compare people with and without tears to identify risk genes. The goal is to better understand why tears happen and why some treatme…

This pilot study is testing a program called Tiwahe Tewichaglapi, which adapts the Family Acceptance Project for Lakota 2SLGBTQ+ youth and their caregivers. The goal is to see if the program is acceptable, safe, and feasible, and to check if it helps reduce depression, anxiety, a…

This study from the University of Michigan is testing whether cognitive rehabilitation (brain training exercises) and transcranial electrical stimulation (mild electrical currents applied to the scalp) can improve thinking abilities like memory, attention, and problem-solving in …

This study follows 550 children who need ECMO (a machine that does the work of the lungs) after sudden, severe breathing failure. Researchers will track their abilities and quality of life for a year after leaving the ICU. They will also compare two groups: one that received ECMO…

Researchers at the University of Michigan and Northwestern University are interviewing children, adults, and parents of young children about their experiences with swelling caused by Nephrotic Syndrome. The goal is to develop a survey that can be used in future clinical trials to…

This study aims to understand how electrical stimulation of the sacral nerve helps people with overactive bladder. Researchers will test two different ways to set the stimulation and see which one works better. Fifteen adults who already qualify for a sacral nerve implant will pa…

This study tests whether sending daily text messages to parents of teens who visited the ER for suicide risk can help prevent future suicide attempts and reduce parental stress. About 420 parent-teen pairs will take part, with parents receiving either supportive texts or standard…

This study tests whether a digital vaccination record system linked to fingerprints can help more children in Ghana complete their malaria vaccine series and other routine shots. About 4,700 pregnant women and mothers of young children will take part. The system will automaticall…

This study tests whether community demonstrations and local chlorine redemption points can increase household water treatment in rural Nigeria. Researchers will compare 20 communities receiving the intervention with 10 control communities. The goal is to see if this approach impr…

This study collects blood and skin samples from 200 people with eczema, food allergies, or neither. Researchers will analyze these samples to find shared genetic or biochemical signals. The goal is to better understand how these conditions are connected, which could lead to bette…

This study looks at how the eczema drug dupilumab works in people of different ethnic backgrounds. Researchers want to understand why Asian and African American people get eczema more often and respond differently to treatment. The study will compare 30 adults with moderate-to-se…

This study at the University of Michigan is testing whether ultrasound can monitor bone graft healing after tooth extraction, potentially replacing more invasive scans. About 140 adults needing a tooth extraction and bone graft for a future dental implant will have their healing …

This study tests whether using low-intensity focused ultrasound to stimulate specific brain areas can help people regain consciousness faster after being sedated with common anesthetics. Researchers will monitor brain activity with fMRI while 168 healthy adults are lightly anesth…

This study looks at how children who stutter perform on rhythm tasks compared to children who don't stutter. Researchers will test rhythm perception and production once a year for three years in 500 children. The goal is to understand how rhythm skills might be linked to brain ac…

This study looks at why people with pre-diabetes or type 2 diabetes tire more quickly during leg exercises. Researchers will test a special low-load resistance training program, sometimes with blood flow restriction, to see if it improves muscle strength, blood flow, and energy u…

This study looks at how emotions, bonding, and eating habits develop together in mothers and their infants. Researchers will observe 150 mother-infant pairs to see how these factors affect a child's eating behavior, diet, and body weight. The study involves giving infants differe…

This study looks at how emotions, bonding, and eating habits develop together in mothers and their babies. Researchers will observe 150 mother-infant pairs to understand how these factors influence a child's eating behavior, diet, and body weight. The goal is to learn more about …

This study looks at how emotions, bonding, and eating habits develop together in mothers and babies. Researchers will observe 150 mother-infant pairs to understand what influences a child's eating behavior and diet. The goal is to learn more about these connections, not to test a…

This early-phase study at the University of Michigan will test whether the diabetes drug sotagliflozin can reduce platelet activity as well as FDA-approved antiplatelet drugs like aspirin, clopidogrel, and apixaban. Twenty healthy volunteers will take each drug for two weeks, and…

This study aims to find biological markers (biomarkers) that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples like blood and wound fluid from 5,000 adults with diabetes and open foot ulcers. The goal is to develop a tool that helps doct…

This study from the University of Michigan is recruiting 3,200 people to understand why some people lose weight and keep it off while others struggle. Participants will undergo a range of tests, including blood work, body composition scans, and fitness assessments. The goal is to…