University Of Michigan

This study tests a 9-week online program designed to help families of LGBTQ+ youth of color become more supportive and accepting. Researchers will measure changes in youth depression, anxiety, drug use, and other risks. The goal is to reduce health disparities caused by family re…

This study follows 20 people with obstructive sleep apnea who are already using a special nasal airway device. Researchers will check in with participants and have them fill out sleep questionnaires after 12 months. The goal is to see how well the device works over time and if it…

This study tests whether text messages tailored to a person's daily habits can help young adults who don't get enough exercise become more active and slow weight gain. About 360 participants will wear an activity tracker for 12 months and receive either personalized messages, ran…

This study tests a mobile health program to help African American young adults (ages 18-30) better control their asthma. Participants use a smartphone app, video calls with an asthma nurse, text reminders, and activity tracking. The goal is to improve asthma symptoms and quality …

This study looks at whether cooling the body for different lengths of time helps children recover brain function after a cardiac arrest outside the hospital. About 900 children aged 2 days to under 18 years who are in a coma after resuscitation will be randomly assigned to differ…

This study is testing a smartphone app called HeartSteps to help people with heart disease become more physically active and stay active long-term. Sixty adults who are finishing or have recently finished cardiac rehab will wear a Fitbit and use the app for 3 months. The goal is …

This study tests a program to help doctors safely reduce or stop thyroid hormone medication in adults aged 65 and older who are getting too much or don't need it. The goal is to prevent harm from overtreatment while keeping thyroid levels healthy. About 900 participants will take…

This study tests a new device placed in the nose (NPA-OSA) to help adults with moderate to severe obstructive sleep apnea who cannot tolerate CPAP machines. Over 30 days, 20 participants will use the device at home to see if it reduces breathing pauses during sleep. The goal is t…

This study tests a 3D-printed, bioresorbable splint that holds open a child's collapsing airway (tracheobronchomalacia). The splint is absorbed by the body over about 5 years. The trial includes 35 children who need breathing support or surgery. The goal is to see if the splint i…

This study tests whether a single dose of calcium gluconate given before a C-section can reduce blood loss in pregnant patients at high risk for heavy bleeding. About 140 participants will receive either the calcium treatment or a placebo. The goal is to see if this simple approa…

This study tests whether the drug dapagliflozin, usually used for diabetes, can reduce the risk of heart problems in women who had high blood pressure during pregnancy. About 200 participants will take either the drug or a placebo daily for six months after giving birth. The goal…

This study looks at whether combining guided exercise with cognitive behavioral therapy (CBT) can help Black men with type 2 diabetes and depressive symptoms improve their blood sugar control and quality of life. About 80 men will take part in a 7-month program that includes week…

This study looks at two ways to surgically repair bone damage caused by infection around dental implants (peri-implantitis). One approach treats the infection and rebuilds bone in the same visit, while the other waits for initial healing before rebuilding. Researchers want to see…

This program provides metreleptin, a synthetic hormone, to patients with partial lipodystrophy who also have diabetes or very high triglycerides. It is for people who previously benefited from the drug in an earlier study and need ongoing treatment. The goal is to help control bl…

This study tests whether tirzepatide, a diabetes drug, can improve blood sugar and lower triglycerides in people with partial lipodystrophy, a rare condition causing abnormal fat loss. About 32 adults with poor diabetes control and high triglycerides will receive the drug or serv…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart conditions. Researchers want to see if the women-only approach leads to better attendance and heart health improvements. About 60 women aged 40-80 will partic…

This study aims to find out if prostate MRI is better than a set of lab tests (like PSA) at detecting serious prostate cancer in men who have not been diagnosed yet. About 950 men scheduled for a biopsy will get both an MRI and lab tests, and researchers will compare which method…

This study tests a new imaging method called photoacoustic tomography (PAT) to see if it can help diagnose rheumatoid arthritis. Researchers will scan the joints of people with arthritis and healthy volunteers every two weeks for up to 10 weeks. The goal is to find out if PAT can…

This study compares a technology-enhanced eye exam done remotely (telemedicine) with a standard in-person eye exam to see which detects three leading causes of blindness—glaucoma, diabetic retinopathy, and cataracts—more effectively. About 900 adults who speak English, Spanish, A…

This study tests two online programs to help low-income families build healthy mealtime, sleep, and screentime routines. About 300 parents of children aged 2-5 will be randomly assigned to either a parent-led group program or a self-paced information program. The goal is to see w…

This study tests a program to help families in rural Michigan store firearms more safely to prevent injuries. About 600 parents with children under 18 and at least one gun at home will take part. The program focuses on locking and unloading guns, and researchers will check if fam…

This study tests a program called YES-IDEAS, which helps middle school students design community projects to feel more empowered and reduce violent behavior. About 512 students in after-school programs in Michigan will take part. Researchers will compare students in YES-IDEAS to …

This study tests whether a program called READY to Stand can help prevent the commercial sexual exploitation of children (CSEC) among racially and ethnically diverse urban high school students. About 3,200 teens in grades 9-12 will take part. Researchers will measure if the progr…

This study tests whether a concentrated grape powder, taken before heart surgery, can prevent a common complication called post-operative atrial fibrillation (POAF). POAF is an irregular heartbeat that often occurs after heart surgery due to inflammation. The study will include 7…

This study compares two programs designed to prevent delirium (sudden confusion) in older adults during hospital stays. About 1,900 patients aged 70 and older will take part, with one program involving family members as active helpers. The goal is to see which approach better red…

This study tests whether a community and faith-based program can encourage Black Americans at high risk for glaucoma to see an eye doctor. Researchers will provide education and extra resources to 60 participants and check if they get eye exams within 6 and 12 months. The goal is…

This study looks at two ways to help young people ages 12-19 who already drink alcohol to cut back. One group gets a short web program, and the other gets that plus supportive text messages for 8 weeks. Parents can also use a free app to talk with their kids about drinking. The g…

This study tests whether sodium nitrate, a natural salt, can prevent kidney damage caused by contrast dye used in heart and CT scans. Researchers will enroll 100 high-risk patients to see if the treatment is practical and effective. The goal is to find a simple, low-cost way to p…

This study looks at whether having a therapy dog present helps children aged 4 to 12 feel less anxious and behave better during the numbing shot at the dentist. Researchers will measure kids' heart rates and distress levels, and ask them and their parents about their experience. …

This study tests a device that uses mild electrical pulses on the skin to treat pain and depression in people with cirrhosis. About 30 adults with cirrhosis and chronic pain will be randomly assigned to receive either real or fake (sham) treatment for 10 weeks. The main goal is t…

This study looks at whether adding emotional regulation therapy to standard low vision rehabilitation can help people with inherited retinal diseases who feel anxious or distressed about their vision loss. Researchers will compare outcomes between those with high and low distress…

This study tests whether four coaching sessions can help veterans with chronic pain use their own cannabis products more effectively. Researchers will enroll 468 veterans who already use or plan to use cannabis for pain. The goal is to improve pain management and related symptoms…

This study explores whether using a virtual reality headset to experience nature scenes can help reduce depression in people with progressive multiple sclerosis. Forty participants will use the Apple Vision Pro at home for short sessions over eight weeks. The goal is to see if th…

This study looks at whether it is safe and less painful to skip placing a temporary tube (stent) after routine kidney stone surgery. About 792 adults with small stones will either get a stent or not, and researchers will track pain and any unplanned doctor visits. The goal is to …

This study compares two surgical procedures to treat ulnar neuropathy at the elbow, a condition that causes numbness, tingling, or weakness in the hand. About 378 adults with confirmed ulnar nerve issues will be randomly assigned to one of the two surgeries. Researchers will trac…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can help people with posterior cortical atrophy (PCA), a rare condition that affects vision and thinking. Fifty participants will receive either real or fake stimulation over 4 days, with an option…

This study looks at a special stitch called STRATAFIX, already approved for use, to close wounds after brain or spine surgery. Researchers want to see if it helps wounds heal better and with fewer problems. About 160 adults having these surgeries will take part. The goal is to ma…

This study tests whether a gentle, noninvasive electrical current applied to the scalp can improve speech fluency in adults who stutter. Researchers will use personalized brain stimulation while participants read aloud in unison with a recording, a technique known to reduce stutt…

This study tests whether a custom dental device called a palatal augmentation prosthesis (PAP) can improve speech and swallowing after surgery for small tongue cancers (T1/T2). About 40 adults will be randomly assigned to receive the device or standard care. Researchers will meas…

This study tests a tablet-based tool called the Epilepsy Visit Planner for adults with drug-resistant epilepsy. The tool helps patients set goals and communicate better with their doctors during clinic visits. Researchers want to see if it improves patient-provider communication …

This study tests an internet-based therapy program called Empower@Home for older adults (50+) with walking difficulties who have mild or more depression symptoms. 64 participants will be randomly assigned to either the program or enhanced usual care. The goal is to see if the pro…

This study compares two common pain relief plans for children after surgery: one uses anti-inflammatory drugs plus acetaminophen, and the other adds low-dose opioids. The goal is to find which option controls pain best with the fewest side effects. About 900 children having tonsi…

This study tests whether virtual reality (VR)-guided therapy can help manage pain for people hospitalized with inflammatory bowel disease (IBD). About 40 participants will try the VR program and report if it's helpful and easy to use. The goal is to see if this approach is a prac…

This early study tests whether women with sexual dysfunction can safely use a non-invasive nerve stimulation device at home to improve arousal. Twenty-four premenopausal and postmenopausal women will either use the device or a smart vibrator for comparison. The main goals are to …

This study looks at whether a 6-week program of non-weight bearing exercise (like seated leg movements) can help diabetic foot ulcers heal faster than standard wound care alone. Researchers will measure blood flow and metabolism changes. The trial involves 40 adults with type 2 d…

This study tests a group therapy program done over Zoom for adults who have both chronic pain and opioid use disorder. The therapy focuses on helping people understand and express their emotions to reduce pain, disability, and related problems like depression and anxiety. About 3…

This early-phase study tests whether using a special standing desk that moves slightly (dynamic standing) can improve walking and motor symptoms in people with Parkinson's disease. Five participants will attend 12 four-hour sessions comparing dynamic standing, static standing, an…

This study looks at whether a physical therapy program can help people with multiple sclerosis (MS) increase their physical activity. Exercise can help manage MS symptoms like fatigue, but many people with MS are not active enough. The study will involve 40 adults with MS who are…

This study tests whether a non-invasive brain stimulation technique, applied for 20 minutes daily over 20 days, can reduce the number of painful migraine days in people with chronic migraine. About 60 people with chronic migraine will receive either real or sham (fake) stimulatio…

This study tests if applying silver diamine fluoride (SDF) to children's weak-enamel molars before a filling helps the numbing shot work better and reduces pain. About 50 kids with a condition called molar-incisor hypomineralization (MIH) will be randomly assigned to get SDF or a…

This study tests whether immersive virtual reality nature scenes can reduce depression, anxiety, and stress in adults with alcohol use disorder who are in an intensive outpatient program. About 50 participants will either receive standard care or add 12 VR nature sessions. The go…

This study tests whether three different diets can reduce bloating and other stomach issues in people with systemic sclerosis (scleroderma). Sixty participants will be randomly assigned to a low FODMAP diet, a CDED diet, or standard NICE dietary advice. The goal is to find which …

This study looks at whether a low sulfur diet can reduce ongoing symptoms like belly pain and diarrhea in people whose Crohn's disease is otherwise quiet. Twenty adults with Crohn's in remission will be randomly assigned to either a low sulfur diet or their usual diet for 8 weeks…

This early study tests whether combining simple passive robots with noninvasive muscle stimulation can help people who have had a stroke regain arm function. Only 4 participants will be enrolled to give feedback on how practical and helpful the device is. The goal is to see if th…

This study tests a short, Zoom-based therapy called Brief Pain Reprocessing Therapy (BPRT) for veterans with chronic low back pain. The goal is to see if the treatment is acceptable, safe, and practical. About 47 veterans will participate, and the study focuses on pain relief and…

This study compares two additional treatments for high tone pelvic floor dysfunction (HTPFD) when used with standard pelvic floor physical therapy. Participants will either take a muscle relaxant (cyclobenzaprine) or use a vibrating massage wand. The goal is to see which option b…

This study tests whether a tailored self-management website called PainGuide can help people with chronic low back pain. Researchers will enroll 550 adults who have had low back pain for at least six months. The goal is to see if the website reduces how much pain interferes with …

This study compares two common pain medicine combinations after surgery: NSAIDs (like ibuprofen) plus acetaminophen (Tylenol) versus low-dose opioids plus acetaminophen. About 900 adults having gallbladder removal, hernia repair, or breast lump removal will take part. The goal is…

This study tests two treatments for abdominal pain in people with irritable bowel syndrome with constipation (IBS-C): a home-based nerve stimulation device called TEA and a medication (escitalopram, also known as Lexapro). About 160 adults with ongoing IBS-C symptoms will be assi…

This study tests whether an online therapy program called Empower@Home can help reduce depression symptoms in homebound older adults. The program delivers cognitive-behavioral therapy through a computer or tablet, with weekly support calls from trained coaches. Researchers will c…

This study is testing whether a combination of thinking exercises and a gentle, non-invasive form of electrical brain stimulation can help improve memory, attention, and problem-solving in adults aged 50 and older. Researchers want to see if these methods, used alone or together,…

This study is gathering information and biological samples from 300 people with FSGS or MCD who have had or will have a kidney transplant. Researchers want to learn why the disease sometimes comes back after transplant, which can lead to graft loss. The goal is to create a shared…

This study looks at how mothers and babies together develop emotions, attachment, and eating patterns. Researchers want to understand how these factors affect a child's eating behavior, diet, and body weight. About 150 mother-infant pairs will take part, and infants must already …

This study is testing a new tool to help adults with eosinophilic esophagitis (EoE) learn about their treatment options and make decisions about their care. About 40 people from the University of Michigan will try the tool or receive general education. The goal is to see if the t…

This study tests a computer program called PICTURE that uses artificial intelligence to alert doctors and nurses when a child's condition may be worsening. The goal is to see if the care team follows the alerts and finds the tool helpful. About 375 clinicians will take part, and …

This study tests a technique called real-time fMRI neurofeedback, which shows people their own brain activity as they lie in an MRI scanner. The goal is to help 70 adults with major depression learn to better regulate brain activity, which may ease their symptoms. Participants wi…

This study tests whether a community-based chlorine distribution program can help families in Nigeria treat their drinking water. About 700 pregnant women and mothers with young children in Kano State will take part. The goal is to see if providing chlorine and community demonstr…

This study looks at how past childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will compare three groups: people with opioid use disorder on buprenorphine, people without the disorder on buprenorphine, and healthy adults.…

This study looks at whether giving an extra dose of the antibiotic cefoxitin during appendix removal surgery can better prevent infection. About 46 people with appendicitis will take part. Researchers will measure antibiotic levels in blood, fat, and appendix tissue to find the b…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will compare brain activity in 150 participants (patients and healthy volunteers) and test a gentle, non-invasive brain stimulation technique called HD…

This study aims to find out why some people succeed at losing weight and keeping it off while others struggle. Researchers will look at factors like blood sugar, metabolism, genetics, and body fat in 3200 adults. The goal is to move away from a one-size-fits-all approach to weigh…

This study is testing a new program designed to support Lakota LGBTQ2S+ youth and their caregivers. The program includes 8 weekly group sessions to improve family relationships and reduce risks like depression, anxiety, and suicide. About 28 youth and their caregivers will take p…

This study looks at people having their wisdom teeth removed under deep sedation. Researchers will compare cannabis users and non-users to see if they need different amounts of sedative drugs or have different vital signs during the procedure. The goal is to understand how cannab…

This study tests a new disposable wearable activity monitor called VERABAND™ in people with chronic low back pain. Researchers want to see if doctors find it easy to use and if they would adopt it in their clinics. About 360 clinicians and patients will take part at multiple pain…

This study looks at whether a person's genetic makeup affects how well the heart drug metoprolol works for heart failure. Researchers will give the drug to 100 people with heart failure and track their heart function and drug levels. The goal is to learn if a genetic score can he…

This study is testing a program that combines therapy (CBT) with a team of caring adults chosen by the teen to help prevent suicide. Researchers want to see if Black teens aged 12-17 who are at risk for suicide find this program acceptable and practical. The study will enroll 15 …

This study is testing a mobile app designed to help people in recovery from both opioid and alcohol use disorders. Researchers want to see if the app is easy to use and acceptable to patients. The study involves 50 people enrolled in Michigan Medicaid who are already taking medic…

This study tests whether sending supportive text messages to parents can help teens who recently visited the emergency room for suicidal thoughts or attempts. Researchers will track teen suicidal behavior and parent stress over six weeks. The study involves 420 parent-teen pairs …

This study looks at how the eczema drug dupilumab affects people of different ethnic backgrounds. Researchers want to understand why Asian and African American people get eczema more often and respond differently to treatment. The study will compare inflammatory responses in 30 a…

This study looks at how emotions, bonding, and eating habits develop together in mothers and babies. Researchers will measure how much babies work for food rewards and how this relates to feeding and weight. About 150 mother-infant pairs will take part, and the baby must already …

This study aims to understand how electrical stimulation of a nerve in the lower back helps people with overactive bladder. Researchers will measure nerve signals during treatment to see if they can predict which stimulation settings work best. The study involves 15 adults who ar…

This early-phase study at the University of Michigan will compare how well sotagliflozin limits platelet activation (a key step in blood clotting) against FDA-approved antiplatelet drugs. Researchers will measure blood samples from 20 healthy volunteers to see if sotagliflozin ha…

This study looks at brain activity in adults who stutter while they speak. Researchers use MRI scans to compare brain signals during stuttered and non-stuttered speech. The goal is to understand how the brain organizes speech production. About 50 adults aged 18-65 who stutter wil…

This small pilot study tests whether walking on a split-belt treadmill (where each leg moves at a different speed) can improve how the knee bears weight after ACL reconstruction. Nine people who had ACL surgery in the past 10 months will be randomly assigned to one of two trainin…

This study tests if a set of tools—like doctor education, decision aids, and performance feedback—can safely reduce unnecessary medical tests before low-risk surgeries such as breast lumpectomy, gallbladder removal, and hernia repair. Researchers will track how many tests are don…

This study looks at how a gentle, non-invasive brain stimulation technique affects brain activity and memory in healthy older adults and those with mild memory problems. Researchers will use brain scans and memory tests to see if the stimulation causes changes. The goal is to bet…

This study aims to understand how a hormone-suppressing drug (Relugolix Combination Therapy) affects pelvic pain, inflammation, and pain sensitivity in women with moderate-to-severe endometriosis. Researchers will measure changes in blood markers and brain activity to see how the…

This study tests whether giving a one-time dose of vitamin K before surgery can safely lower the blood-thinning effects of warfarin, so patients don't have to stop taking it. Researchers will enroll 20 adults who have been on warfarin for at least 3 months and need a procedure wh…

This study looks at whether having groceries delivered can help low-income pregnant young women gain a healthy amount of weight and eat better. About 570 women in early pregnancy will take part. The goal is to learn if this simple support can improve health for moms and babies.

This study looks at whether CT scans done for lung cancer screening can also help find COPD, a lung disease, in current and former smokers. About 200 people aged 50-80 who smoke or used to smoke will take part. Researchers will check their past CT scans and do breathing tests to …

This study looks at how a diabetes drug called Glipizide dissolves in the stomach and small intestine. Researchers will take samples from the gut, blood, urine, and stool in 40 healthy adults aged 18-55. The goal is to improve lab tests that predict how drugs dissolve in the body…

This study looks at how adding exercise to a weight loss plan changes belly fat and metabolism in ways that may keep you healthier even if you regain some weight. Researchers will compare two groups of adults with obesity: one that loses weight through diet and exercise, and anot…

This study aims to make powered prosthetic legs for above-knee amputees move more naturally by using machine learning. Researchers will collect data from people without amputations to create a model that helps the prosthetic leg adapt to different activities like walking, stairs,…

This study looks at whether certain genes make people more likely to develop rotator cuff tears, a common shoulder problem. Researchers will compare the DNA of 3,500 adults with and without MRI-confirmed tears. The goal is to find genetic markers that could one day help predict r…

This study tests whether a non-invasive brain stimulation technique called HD-tDCS can improve hand movement in healthy older adults. Researchers will compare a standard dose to a personalized dose. The goal is to understand how the brain controls movement and whether tailored st…

This study looks at how emotions, attachment, and eating habits develop together in mothers and their babies. Researchers will watch how these factors affect feeding behavior, food choices, and body growth. About 150 mother-infant pairs will take part, and the baby must already b…

This study follows 550 children who needed a machine called ECMO to breathe after a sudden lung failure. Researchers want to learn how these children recover over the next year, including their thinking, movement, and quality of life. They will also compare two different ways of …

This study looks at why people with pre-diabetes or type 2 diabetes feel more tired and weak in their legs during exercise. Researchers think it may be due to blood vessel problems. They will test a special exercise program that uses blood flow restriction to better understand th…

This study will enroll 5,000 adults with diabetes and open foot ulcers to test whether certain biomarkers can predict which wounds will heal. Researchers will collect blood, wound fluid, and tissue samples to measure healing, infections, and amputations over 52 weeks. The goal is…

This study tests whether a digital vaccination record system linked to fingerprints can help more children in Ghana complete their malaria vaccine series and other routine shots. About 4,700 pregnant women and mothers of young children will take part. The system will automaticall…

This study aims to uncover whether eczema (atopic dermatitis) and food allergies share unique genetic or biochemical markers. Researchers will collect blood and skin samples from 200 participants, including those with food allergies, eczema, or neither. The goal is to create a mo…

This study follows about 500 people with lipodystrophy, a rare condition where the body loses fat tissue, leading to serious issues like diabetes and very high blood fats. Researchers will check participants yearly for 5 to 7 years to see how often these problems occur and what p…

This study explores whether having resident doctors meet patients they treated in the ICU can reduce burnout and increase professional fulfillment. About 30 residents and their former ICU patients will participate. The goal is to see if these follow-up visits help doctors feel mo…

This study interviews 150 children, adults, and parents about their experiences with swelling caused by Nephrotic Syndrome. Researchers will use the information to create a survey that helps test new medications. No treatment is given; the goal is to better understand symptoms.

This study looks at how the brain works under different levels of anesthesia using two common drugs. Researchers will use low-intensity focused ultrasound to stimulate specific brain areas while taking detailed brain scans. The goal is to better understand mental function during …

This study aims to create a large collection of medical information, DNA, blood, and tissue samples from 15,000 people with and without heart conditions. Researchers will use this biobank to better understand diseases like aortic aneurysm, heart failure, and bicuspid aortic valve…

This study looks at two ways to get rid of leftover opioid pain pills after surgery: mailing them in or using a special in-home disposal method. About 100 people who have not taken opioids before will be assigned one of these methods. The goal is to see which approach works bette…

This study helps people with certain kidney diseases (like nephrotic syndrome or FSGS) find clinical trials that might work best for them based on their individual biology. Researchers analyze each participant's molecular profile and share results with their doctor. The goal is t…

This study tests a program called HealthyLifetime that helps older adults stay healthy and independent in their own homes. Researchers will work with 120 participants to see if the program improves their health habits, confidence, and quality of life. The goal is to find better w…