Can thinking shrink depression? new Brain-Feedback study tests mind over mood

NCT ID NCT06050070

Recruiting now Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a technique called real-time fMRI neurofeedback, where people with depression learn to control brain activity by watching a visual pattern change in real time during an MRI scan. Researchers want to see if this can help regulate brain networks linked to depression. The trial involves 58 adults with major depressive disorder and is funded by the National Institutes of Health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: real-time fMRI neurofeedback
What this could lead to: If successful, this could point toward a non-drug technique to help people with depression better control brain activity and manage symptoms.
What could go wrong: This is a very early, small study (58 people) testing feasibility, not treatment. It may not lead to any clinical benefit, and results may not apply to all depression patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

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