University Of Michigan

This study looks at whether giving an extra dose of the antibiotic cefoxitin during appendix removal surgery can better prevent infections compared to the usual single dose before surgery. Researchers will measure antibiotic levels in blood, fat, and appendix tissue from 46 parti…

This study looks at how the part of a dental crown that sits under the gums is shaped and whether that shape helps keep gums and bone healthy. Thirty people with gum disease who already have a dental implant will get a custom crown. Researchers will measure bone loss, gum thickne…

This study tests different ways to help people drink less alcohol before and after elective surgery. The goal is to improve surgical outcomes and long-term health. About 440 adults scheduled for major non-cancer surgery are taking part.

This trial tests whether placing a temporary crown immediately after a dental implant helps keep gum tissue stable compared to placing the implant alone. About 44 adults with a non-restorable front tooth will be randomly assigned to one of the two approaches. Researchers will mea…

This study looks at whether a person's age influences the quality of platelet-rich fibrin (PRF) — a natural healing material made from their own blood — and how well it helps the jawbone heal after a molar is pulled. Researchers will compare healing in adults aged 20 to 80 who re…

This study tests whether personalized smartphone notifications can improve mood, sleep, and physical activity in medical interns. Participants receive mood, activity, or sleep tips through a mobile app, with the content chosen by a learning algorithm. The goal is to see if these …

This study tests a program called PC CARES, which trains local health workers in rural Alaska to lead a series of group discussions called Learning Circles. The goal is to help adults who work with youth learn about suicide prevention, build community support, and take action. Re…

This study tests a new reinforced PTFE mesh (RPM) against a standard collagen membrane for treating peri-implantitis, a gum infection around dental implants. Thirty-two adults with at least one infected implant will receive surgery to clean the implant, fill the bone defect with …

This study compares two standard methods for treating severe traumatic brain injury in the ICU. One method monitors only brain pressure, while the other also tracks brain oxygen levels. About 1,094 patients will take part to see which approach leads to better recovery and surviva…

This study tests new technology-driven programs to help people with alcohol use disorder manage their drinking and well-being. The programs focus on personal goals and healthy behaviors. Researchers will see if these virtual tools help people start and stick with treatment and re…

This study tests whether a synthetic bone graft material (carbonate apatite) helps preserve the jawbone after tooth extraction better than grafts from human or cow bone. Researchers will measure bone changes using scans and tissue samples. The study involves 45 adults needing a t…

This study tests a new high-strength ceramic material for dental crowns that can be made in a single appointment using a computer technique, avoiding the need for a temporary crown. 48 adults with a decayed, fractured, or poorly restored molar or premolar will receive the crown a…

This study tests a special afterschool program called CHAMP that helps children ages 5-8 improve their motor skills and become more physically active. About 264 kids from afterschool programs in Michigan will take part, with half doing CHAMP and half continuing their usual activi…

This pilot study tests whether drinking tart cherry concentrate for three days before heart valve surgery can reduce the risk of post-operative atrial fibrillation (an irregular heartbeat). The study involves 50 adults aged 50-79 who are in normal heart rhythm before surgery. Res…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This study tests whether a DASH diet or a very low-carbohydrate diet is better at improving blood sugar control and body weight in adults with polycystic ovary syndrome (PCOS). 223 participants will follow one of the two diets for 12 months, with support from psychological skills…

This study follows children with hypotonia (low muscle tone) who have obstructive sleep apnea. They use a flexible silicone nasal tube called ssNPA at night to keep the airway open. Researchers will check how well it works and if children can tolerate it over a year.

This study tests three different eating plans to see which helps overweight adults at risk for colorectal cancer eat healthier and lose weight. About 240 participants will follow one of the plans for 12 months, with support from phone calls and a phone app. The goal is to find be…

This study is testing a mobile-friendly app called DASH that provides information and guidance about PrEP (a daily pill that prevents HIV) to people who have used an HIV self-test kit. The app helps users explore their values and make informed decisions about starting PrEP, with …

This study tests whether adding peer support and healthy food vouchers to a standard diabetes prevention program helps low-income adults with prediabetes stick with the program and lower their risk of developing type 2 diabetes. About 142 participants will either get the standard…

This study tests whether a mobile app called Ane-Roadmap can help adolescents aged 12 to 17 recover emotionally after a scheduled surgery. The app offers simple activities like savoring happy moments, keeping a gratitude diary, and planning pleasant events. Researchers want to se…

This study tests whether a 24-week physical therapy program can help people with multiple sclerosis become more physically active. Forty participants will receive tailored exercise support and education. The goal is to see if this approach is feasible and helps manage MS symptoms…

This study tests whether a virtual reality (VR) program can help people with inflammatory bowel disease (IBD) manage pain and stress. Forty adults with IBD will use a VR headset at home for 4 weeks, doing activities like breathing exercises, meditation, and interactive games. The…

This study looks at whether a peer support program is acceptable and helpful for people with mild depression or anxiety who are starting or receiving hormone care. One hundred participants are randomly assigned to either the peer support group or usual care. The program includes …

This study tests whether a smartphone app that teaches mindfulness and sends personalized messages can reduce depression and anxiety in people waiting for in-clinic mental health services. About 4,400 adults seeking care at Michigan Medicine will use the app and report their symp…

This study tests whether a brief behavioral class called Empowered Relief can reduce disability and symptoms in adults with chronic migraine. 300 participants will be randomly assigned to the class, a health education session, or usual care, all done remotely. The goal is to see …

This study tests an 8-week online group program designed to help people with scleroderma improve their thinking skills and overall well-being. Researchers will compare participants who take the program right away to those on a waitlist. The goal is to see if the program boosts me…

This study tests whether an internet-based job interview training program (Virtual Interview Training) helps autistic young adults improve their interview skills and find jobs. About 200 participants will either use the training or continue with their usual services. Researchers …

This study tests a classroom program called the Kids' Empowerment Program (KEP) to help children ages 6 to 12 reduce symptoms of anxiety and depression. About 120 children will take part, with some starting the program right away and others later. The goal is to give kids practic…

This study tests a personalized yoga coaching program for people with lupus who have chronic pain. Fifteen participants work with a coach to create a yoga practice that fits their needs and limits. The goal is to see if the program is feasible and if it helps reduce pain. It is a…

This study tests whether Aquamin, a natural multi-mineral product from red marine algae, can reduce bad breath (halitosis). Fifteen adults with self-reported halitosis will take Aquamin for 90 days and report changes in their breath-related quality of life. The goal is to see if …

This study tests a web tool called My Health, My Choice that helps people with health conditions (like diabetes or high blood pressure) understand their birth control options. About 795 participants will either use the tool before a clinic visit or receive usual care. The goal is…

This study investigates whether mental activity—called covert consciousness—can occur during sedation with dexmedetomidine or ketamine. Healthy volunteers will undergo fMRI scans while performing mental imagery tasks (like imagining playing tennis) at different sedation depths. T…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will use EEG and fMRI to measure brain activity and test a gentle brain stimulation technique called HD-tDCS. The goal is to understand pain processing…

This study follows thousands of medical interns through their first year of residency—a time of intense, predictable stress—to see how genes and stress together might trigger depression. By tracking mood and genetic markers over 12 months, researchers hope to untangle why some pe…

This study follows 200 adults aged 30-55 who smoke or have early COPD to learn how the disease progresses. Researchers will use breathing tests, symptom surveys, and CT scans to find early warning signs. The goal is to better understand risk factors and improve future care for CO…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to walking problems, falls, and thinking skills. The goal is to understand how t…

This observational study looks at the financial and social challenges faced by informal caregivers of people with cirrhosis. Researchers will measure out-of-pocket costs, lost work time, and financial distress using surveys. The goal is to understand how these burdens affect care…

This study looks at how children's eating behaviors in infancy relate to their diet, growth, and behavior when they reach school age. About 400 children and parents will take part in food-related activities and questionnaires. The goal is to understand early influences on eating …

This study follows 550 children who need ECMO (a machine that does the work of the lungs) after sudden, severe breathing failure. Researchers will track their abilities and quality of life for a year after leaving the ICU. They will also compare two groups: one that received ECMO…

This study will test different levels of support—from virtual training to in-person coaching—to help hospitals use proven methods for inducing labor. Researchers will work with 64 maternity clinicians to see which approach works best. The goal is to improve care for mothers and b…

This study looks at how straining affects people with bleeding hemorrhoids. Researchers will use surveys and a standard test called anorectal manometry to understand the link between pelvic floor problems and hemorrhoid symptoms. The goal is to help doctors give better treatment …

This study looks at whether a new care plan can help more people with pulmonary embolism (a blood clot in the lungs) go home from the emergency room instead of being admitted to the hospital. Researchers are working with 14 hospital ERs in Michigan to track changes in how often l…

This study is exploring what happens when women have better financial access to birth control. Researchers are tracking about 5,000 women in Michigan to see how it affects their use of contraception, pregnancy rates, education, jobs, finances, and overall well-being. The goal is …

This study tests whether sending personalized text messages at the right time can help young adults who are not very active to move more and gain less weight. About 360 participants will wear an activity tracker for 12 months and receive either personalized messages, random messa…

This study looks at how a baby's emotions, attachment to mom, and feeding habits work together to affect weight gain in the first year of life. Researchers will follow 250 mother-infant pairs to understand what leads to healthy growth or future obesity. The goal is to find ways t…

This study tests whether telehealth programs can help people manage their alcohol use and improve well-being. About 300 adults with alcohol use disorder will join remotely via video or phone. They will be split into two groups: one gets a telehealth program, the other gets usual …

This study looks at whether counseling sessions done over video call (telehealth) are practical and well-liked by people with substance use disorder who are not currently getting treatment. About 50 participants will try the program and share their feedback through surveys. The g…

This study looks at whether a simple bedside device called the Rectal Expulsion Device (RED) can help doctors evaluate chronic constipation during a regular office visit. About 109 adults with chronic constipation will use the device and answer a survey. The goal is to see if thi…

This study was designed to see if a tracking system called Care Companion could help family caregivers of people with dementia who are at risk of wandering. The study was withdrawn before any participants were enrolled, so no results are available. It would have asked caregivers …

This study looks at whether a 15-minute meeting between ICU nurses and patients they once cared for can boost the nurses' sense of fulfillment and reduce burnout. Twenty nurses and ten former ICU patients are taking part. Nurses are randomly assigned to either meet with a patient…

This study tests four different methods for removing the surface layer of gum tissue during dental grafting surgery. The methods include a surgical blade, a special drill (mucotome), a diamond bur, and a laser. Researchers will measure how much tissue remains, how long the proced…

This study uses MRI scans to understand how different neck positions affect the flow of cerebrospinal fluid (the fluid around the brain and spine) in people with Chiari malformations and similar neck abnormalities. Researchers will compare fluid flow in healthy volunteers and pat…

This study looks at a Michigan school program called Pathways to Potential (P2P). In this program, social workers called success coaches help students and families find community resources for needs like transportation or jobs. The goal is to see if this program lowers youth viol…

This pilot study tests a new educational tool to help people with chronic kidney disease (CKD) make informed decisions about pregnancy and contraception. About 70 participants will receive a decision aid before a routine nephrology appointment and then complete a survey to measur…

This study tests a wearable device that delivers mild electrical stimulation to the wrist (called transcutaneous electrical acustimulation, or TEA) in healthy adults. Participants wear the device for three days and use it for 60 minutes daily. The goal is to see if the device is …