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Could your age determine how well a blood clot heals your tooth socket?

NCT ID NCT07023757

Disease control Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time

Summary

This study looks at whether a person's age influences the quality of platelet-rich fibrin (PRF) — a natural healing material made from their own blood — and how well it helps the jawbone heal after a molar is pulled. Researchers will compare healing in adults aged 20 to 80 who receive either a PRF plug or a standard collagen plug in the empty socket. The goal is to see if PRF works differently depending on age, which could guide more personalized dental care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich fibrin (PRF) plug or collagen plug placed in the extraction socket
What this could lead to
If age-related differences in PRF quality are found, it could help personalize socket preservation techniques for better healing and implant success.
What could go wrong
This is a small, early-stage study with only 44 participants, so results may not apply to everyone. The healing benefits of PRF may not differ significantly by age.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age range: 20 to 80 years. 2. Patients must require tooth extraction (molars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable. 3. Non-infected sockets with intact buccal bone (≥1.5 mm in thickness measured through calipers) 4. Patients interested in implant placement following tooth extraction. Exclusion Criteria: 1. Allergies or hypersensitivities to study related medications. 2. Hematologic disorders/blood dyscrasias. 3. Active infectious diseases of any kind. 4. Liver or kidney dysfunction/failure. 5. Uncontrolled diabetes (HbA1c \> 8). 6. Active cancer treatment - such as active chemotherapy or radiation therapy. 7. Taking medications that will affect their bone healing (for example, bisphosphonates, Long-term NSAIDs use, Steroid). 8. Metabolic bone diseases that affect bone healing such as osteoporosis. 9. Pregnant or lactating women (self-reported). 10. Smoke 10 or more cigarettes per day (self-reported). 11. Poor oral hygiene. 12. Systemic diseases that compromise the immune system 13. Anti-coagulant therapy

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healing wound

How to take part

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  1. The places running it

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  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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Contacts and locations

Locations

  • University of Michigan School of Dentistry

    Ann Arbor, Michigan, 48109, United States

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