New study tracks kids on life support to see how timing affects their brains

NCT ID NCT05388708

Ongoing Knowledge-focused Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 15, 2026 · Updated 2 times

Summary

This study follows 550 children who need ECMO (a machine that does the work of the lungs) after sudden, severe breathing failure. Researchers will track their abilities and quality of life for a year after leaving the ICU. They will also compare two groups: one that received ECMO only after other treatments failed, and another that got ECMO as part of usual care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors choose the best timing for ECMO to improve children's long-term brain development and quality of life.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may take years and might not apply to all children.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome adult acute respiratory distress syndrome pediatric acute respiratory distress syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE RESPIRATORY DISTRESS SYNDROME EXTRACORPOREAL MEMBRANE OXYGENATION

Contacts and locations

Locations

Akron Children's Hospital

Akron, Ohio, 44308, United States
Alder Hey Children's Hospital

Liverpool, L12 2AP, United Kingdom
Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Atrium Health Wake Forest Baptist | Brenner Children's Hospital

Winston-Salem, North Carolina, 27157, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Cardinal Glennon Children's Hospital

St Louis, Missouri, 63104, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30342, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital and Vall d' Hebron Women's Hospital

Barcelona, 08035, Spain
Children's Hospital of Michigan

Detroit, Michigan, 48201, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Medical Center Dallas

Dallas, Texas, 75235, United States
Children's Memorial Hermann Hospital

Houston, Texas, 77030, United States
Children's Mercy

Kansas City, Missouri, 64108, United States
Children's Minnesota Hospital

Minneapolis, Minnesota, 55404, United States
Children's Nebraska

Omaha, Nebraska, 68114, United States
Children's Wisconsin

Milwaukee, Wisconsin, 53226, United States
Children's of Alabama

Birmingham, Alabama, 35233, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cleveland Clinic Children's Hospital

Cleveland, Ohio, 44106, United States
Cohen Children's Medical Center

Queens, New York, 11040, United States
Comer Children's Hospital

Chicago, Illinois, 60637, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
Dell Children's Medical Center

Austin, Texas, 78723, United States
Duke Children's Hospital & Health Center

Durham, North Carolina, 27705, United States
ECMO Centrum Karolinska

Stockholm, 17176, Sweden
Evelina London Children's Hospital

London, SE1 7EH, United Kingdom
Freeman Hospital

Newcastle upon Tyne, NE77DN, United Kingdom
Fundacion Cardiovascular De Colombia

Floridablanca, 681004, Colombia
Great Ormond Street Hospital for Children

London, WC1N 3JH, United Kingdom
Hasbro Children's

Providence, Rhode Island, 02903, United States
Hassenfeld Children's Hospital at NYU Langone

New York, New York, 10016, United States
Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States
Hospital Gregorio Maranon

Madrid, 28007, Spain
Hospital de Santa Maria

Lisbon, 1649-028, Portugal
Inova L.J. Murphy Children's Hospital

Falls Church, Virginia, 22042, United States
Istituto Giannina Gaslini

Genoa, 16147, Italy
John R. Oishei Children's Hospital

Buffalo, New York, 14203, United States
Johns Hopkins Children's Center

Baltimore, Maryland, 21287, United States
Kapi'olani Medical Center for Women & Children

Honolulu, Hawaii, 96826, United States
Le Bonheur Children's Hospital

Memphis, Tennessee, 38103, United States
Leicester Children's Hospital

Leicester, LE3 9QP, United Kingdom
Loma Linda University Children's Hospital

Loma Linda, California, 92354, United States
Lucile Packard Children's Hospital Stanford

Palo Alto, California, 94304, United States
MUSC Shawn Jenkins Children's Hospital

Charleston, South Carolina, 29425, United States
Mayo Eugenio Litta Children's Hospital

Rochester, Minnesota, 55902, United States
Medical City Children's Hospital

Dallas, Texas, 75230, United States
Monroe Carell Jr. Children's Hospital at Vanderbilt

Nashville, Tennessee, 37232, United States
N.C. Children's Hospital

Chapel Hill, North Carolina, 27514, United States
Nationwide Children's Hospital

Columbus, Ohio, 43215, United States
Nemours Children's Hospital, Delaware

Wilmington, Delaware, 19803, United States
Nemours Children's Hospital, Florida

Orlando, Florida, 32827, United States
NewYork-Presbyterian Komansky Children's Hospital

New York, New York, 10065, United States
NewYork-Presbyterian Morgan Stanley Children's Hospital

New York, New York, 10032, United States
Norton Children's Hospital

Louisville, Kentucky, 40202, United States
OHSU Doernbecher Children's Hospital

Portland, Oregon, 97239, United States
OSF Healthcare Children's Hospital of Illinois

Peoria, Illinois, 61637, United States
Ochsner LSU Health Shreveport

Shreveport, Louisiana, 71103, United States
Oklahoma Children's Hospital OU Health

Oklahoma City, Oklahoma, 73104, United States
Orlando Health Arnold Palmer Hospital for Children

Orlando, Florida, 32806, United States
Penn State Health Children's Hospital

Hershey, Pennsylvania, 17033, United States
Perth Children's Hospital

Perth, WA 6009, Australia
Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States
Pontificia Universidad

Santiago, 8331150, Chile
Primary Children's Hospital

Salt Lake City, Utah, 84113, United States
Queensland Children's Hospital

South Brisbane, QLD 4101, Australia
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Royal Brompton Hospital

London, SW3 6NP, United Kingdom
Royal Hospital for Children

Glasgow, G51 4FT, United Kingdom
Sanford Children's Hospital

Sious Falls, South Dakota, 57105, United States
Sant Joan de Deu Barcelona Hospital

Barcelona, 08950, Spain
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Southampton Children's Hospital

Southampton, SO16 6YD, United Kingdom
St. Louis Children's Hospital

St Louis, Missouri, 63110, United States
Starship Children's Hospital

Grafton, Aukland, 1023, New Zealand
Stollery Children's Hospital

Edmonton, Alberta, T6G 2B7, Canada
Texas Children's Hospital

Houston, Texas, 77030, United States
The Children's Hospital at Westmead

Westmead, NSW 2145,, Australia
The Hospital for Sick Children

Toronto, Ontario, M5G 1E8, Canada
The Royal Children's Hospital Melbourne

Melbourne, VIC 3052, Australia
UCLA Mattel Children's Hospital

Los Angeles, California, 90095, United States
UCSF Benioff Children's Hospital - San Francisco

San Francisco, California, 94158, United States
UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609, United States
UF Health Shands Children's Hospital

Gainesville, Florida, 32608, United States
UNM Children's Hospital

Albuquerque, New Mexico, 87106, United States
UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
UVA Children's Hospital

Charlottesville, Virginia, 22903, United States
UW Health American Family Children's Hospital

Madison, Wisconsin, 53792, United States
University Health Women's & Children's Hospital

San Antonio, Texas, 78229, United States
University of Iowa Health Care Stead Family Children's Hospital

Iowa City, Iowa, 52242, United States
University of Michigan - Mott Children's Hospital

Ann Arbor, Michigan, 48109, United States
Valley Children's Hospital

Madera, California, 93636, United States
Yale New Haven Children's Hospital

New Haven, Connecticut, 06511, United States

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