Pediatric acute respiratory distress syndrome

This study tests whether giving caffeine citrate to moderately preterm infants for 28 days after hospital discharge can prevent apnea (breathing pauses) that lead to sick visits. About 340 babies in Zambia will receive either caffeine or a placebo daily. Researchers will also che…

This early-stage trial tests a new drug called PRS CK STORM, made from a mix of immune and fat cells, to see if it can safely calm the 'cytokine storm'—a dangerous overreaction of the immune system—in people with severe lung infections from COVID-19, flu, or RSV. The study will e…

This study compares using 30% versus 60% oxygen when resuscitating extremely preterm babies (born before 29 weeks). The goal is to see which oxygen level leads to better survival and fewer long-term developmental problems like cerebral palsy or vision/hearing loss. About 1,200 ba…

This study looks at a new method for removing breathing tubes from very premature babies (born before 32 weeks). Normally, doctors remove the tube first and then put on a gentle breathing mask. The new method puts the mask on first, before removing the tube. Researchers want to s…

This study tests whether using a real-time lung imaging tool (EIT) to guide breathing therapy helps people who have been on a breathing machine for a long time. The goal is to see if this personalized approach helps them breathe on their own sooner compared to standard therapy. T…

This study compares two medications (calfactant and poractant alfa) given through a thin tube to help premature babies breathe. The babies are born before 30 weeks and have respiratory distress syndrome. The goal is to see which drug works better at reducing the need for a breath…

This Phase 3 trial tests a new inhaled medication called APC-0101 in 520 premature babies born between 26 and 33 weeks who have respiratory distress syndrome. The drug is a surfactant that helps keep tiny air sacs in the lungs open. Some babies receive the active drug through a s…

This study tests if giving surfactant (a natural substance that helps lungs stay open) through a less invasive method helps premature babies with breathing problems survive. About 1,500 babies weighing 1.5 to 4.4 pounds will receive this treatment in African hospitals that lack b…

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This study looks at two different ways to use ventilators for children with acute respiratory distress syndrome (ARDS), a serious lung condition. The goal is to see which method helps children recover faster and breathe better. About 160 children will take part, and the results w…

This study tests whether giving L-carnitine, a natural substance, to premature babies with respiratory distress syndrome (RDS) can help them survive and gain weight better. Researchers will compare babies who get L-carnitine plus standard care to those who get standard care alone…

This study tests whether giving pregnant people at risk of preterm birth half the usual dose of a steroid (Celestone) works as well as the full dose to prevent serious health problems in their babies. About 3,250 participants will receive either one or two doses after an initial …

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study compares two ways of using a heart-lung support machine (ECMO) during lung transplants: using it routinely for all patients versus using it only when problems arise. About 218 adults with end-stage lung disease will take part. The goal is to see which approach leads to…

This study tests whether a special breathing machine called high-frequency oscillation ventilation (HFOV) works better than standard mechanical ventilation for very premature babies (born at 24 to 31 weeks) who have acute respiratory distress syndrome (ARDS). The goal is to see i…

This study looks at 110 preterm babies (born at 34 weeks or earlier) with breathing problems who need a special ventilator. Doctors want to find out which of two weaning methods helps them come off the machine safely with the fewest complications. The main goal is to see which me…

This study tests whether early physiotherapy, taught to parents, can improve movement and development in babies at risk for problems like cerebral palsy. Fifty infants from the NICU will be randomly assigned to get either the special program or standard care. Researchers will mea…

This study tests whether using a lung ultrasound score can help doctors decide when to give surfactant therapy to premature infants with respiratory distress syndrome. Surfactant is a substance that helps babies' lungs stay open, but giving it too late can reduce its benefit. The…

This study is testing a special MRI scan that uses xenon gas to take detailed pictures of lung function. It includes 260 healthy volunteers and people with lung diseases like asthma, COPD, and cystic fibrosis. The goal is to see if this method can better detect and measure lung p…

This study looks at whether using lung and heart ultrasound can help emergency doctors give the right treatment faster to older adults (over 65) who come to the ER with sudden breathing trouble. About 504 participants will be enrolled. The goal is to see if ultrasound reduces the…

This study looks at two substances in the blood—endocan and copeptin—in 40 premature babies born between 28 and 36 weeks who have breathing trouble (respiratory distress syndrome). Researchers will measure these markers on the first day of life to see if they can predict how seve…

This study tests whether a computer alert can help doctors remember to prescribe blood-thinning medicine for high-risk patients after they leave the hospital. Blood clots are a serious risk for some hospitalized patients, even after discharge. The trial will include 400 adults ag…

This study tests whether using a video camera (video laryngoscopy) helps doctors give surfactant—a medicine that helps lungs work—to very premature babies more successfully on the first try compared to the standard direct-look method. About 100 babies born at 28 weeks or earlier …

This study compares two ways of giving a lung-opening medicine (surfactant) to premature babies with breathing problems. The newer method uses a soft mask placed in the throat instead of a breathing tube down the windpipe. Researchers want to see if the gentler method works just …

This study looks at whether giving surfactant (a lung treatment) over 1 minute or 5 minutes helps very premature babies (under 28 weeks) stay more stable. The goal is to see which speed leads to better oxygen levels in the blood and brain. 76 babies will take part, and the result…

This study looks at whether adding a gentle chest-squeezing technique to standard postural drainage can immediately improve oxygen levels and reduce breathing difficulty in preterm infants with respiratory distress syndrome. Fourteen babies born by C-section will be randomly assi…

This study looks at 50 children (over 1 year old) in intensive care who are on breathing machines due to acute respiratory distress syndrome (ARDS). Researchers want to see if two methods can reliably measure airway opening pressure, which could help doctors personalize ventilati…

This study looks at preterm infants who need breathing support from a machine called nasal CPAP. Researchers want to find out how much oxygen actually reaches the baby's lungs by placing a small tube in the back of the mouth and using soft bands around the chest to measure lung e…

This study compares two types of CPAP machines that help premature babies breathe. One delivers a constant flow of air, the other a variable flow. Researchers will measure the babies' diaphragm activity to see if constant flow works just as well. The study involves 20 infants bor…

This study looks at how a pregnant woman's body handles caffeine and how much of it reaches her unborn baby. Researchers will give a small dose of caffeine to 30 women at risk of preterm delivery before a planned C-section. Blood samples from the mother, placenta, and newborn wil…

This study looks at whether being treated at a high-altitude hospital affects survival for children with acute respiratory distress syndrome (severe lung failure). Researchers will collect data from 1,600 children in intensive care units around the world. The goal is to understan…

This study is analyzing the exhaled breath of 5,000 people with lung or airway diseases to find unique molecular patterns. The goal is to better identify and distinguish different respiratory conditions and improve disease management. Participants simply provide breath samples, a…

This study is testing whether two non-invasive tools—ultrasound and electrical impedance tomography (EIT)—can help doctors monitor breathing muscles in patients with acute respiratory failure who are using non-invasive breathing support. Up to 100 adults will be enrolled, with me…

This study looks at whether a lung ultrasound done shortly after birth can predict which late preterm babies (born 34–36 weeks) will have breathing problems in the first two days of life. Researchers will compare three different ultrasound scoring methods. The goal is to help doc…

This observational study looks at 30 adults with acute respiratory failure on mechanical ventilation. Researchers want to see if a bedside device called electrical impedance tomography (EIT) can reliably guide ventilator pressure settings, compared to the current gold standard (C…

This study looks at how changing the pressure on a ventilator affects the lungs and heart of very premature babies (born before 34 weeks). Researchers will try different pressure levels and use ultrasound and imaging to see which setting works best for breathing and blood flow. T…

This study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…

This study looks at how painkillers and sedatives are given to patients on ECMO, a life-support machine for severe heart or lung failure. Researchers will first review current sedation practices in UK hospitals, then work with patients, families, and staff to design a safer sedat…

This study tests whether a new device called Electrical Impedance Tomography (EIT) can help doctors find the best pressure settings for breathing support in preterm babies born before 32 weeks. The goal is to prevent lung collapse and reduce lung injury. Thirty babies will be mon…

This study creates a registry and biorepository of lung images and biological samples from 100 people with pulmonary disease. Researchers will use this information to better understand imaging biomarkers and develop new analysis methods for CT and MRI scans. Participants must alr…

This study looks at whether using a video laryngoscope (a tool with a camera) helps doctors place a breathing tube in newborns more safely than the standard direct laryngoscope. About 840 babies across multiple hospitals will be included. The goal is to see if video laryngoscopy …

This study observes breathing patterns in 30 premature infants (born at 32 weeks or earlier) before and after removing their breathing tubes. Soft elastic bands placed on the chest and abdomen measure how well the chest and belly work together. The goal is to see if these measure…

This study tests a computer program that gives doctors step-by-step advice on how to set breathing machines for children with acute respiratory distress syndrome (ARDS). The goal is to see if the tool can be used in multiple hospitals and if doctors follow its recommendations. Up…

This study compares lung ultrasound to standard chest X-rays in very preterm infants (born before 32 weeks) who need breathing support. The goal is to see if ultrasound can safely reduce the number of X-rays, lowering radiation exposure. About 180 babies will be randomly assigned…

This study will follow 1000 adults for up to 10 years, using a special type of CT scan (photon-counting) to look for lung nodules, tumors, and other lung conditions. Researchers will also use artificial intelligence to create a virtual copy of each person's lungs, called a 'digit…

This study looks at two methods of giving surfactant (a medicine that helps lungs work) to premature babies with breathing problems. One method uses a thin tube without a breathing tube, and the other uses a standard breathing tube. Researchers will use lung ultrasound to see whi…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This study tracks lung ultrasound images over time in preterm babies born before 32 weeks who need surfactant for breathing problems. Researchers want to see if the way surfactant is given changes how the lungs look on ultrasound. About 68 babies will take part to help doctors le…

This study is collecting data from 2,200 children aged 0 to 12 who come to emergency rooms with breathing problems. Researchers will use videos and clinical information to train an artificial intelligence system to automatically recognize different breathing patterns. The goal is…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study looks at whether analyzing stomach fluid from newborns can predict if they will need breathing support for more than 6 hours after birth. Researchers will enroll 500 babies born at 32 weeks or later in a lower-level NICU. The goal is to see if a new algorithm can accur…

This study looks at how to adjust breathing machine settings for people with moderate-to-severe ARDS, a serious lung condition. Researchers will use a special imaging technique to see how air and blood flow match up in the lungs. The goal is to find the best settings for each pat…

This study is building a bio-bank of blood samples from people who have had a lung transplant. Researchers will use these samples to study advanced lung diseases and improve transplant care. The goal is to better understand how infections and other factors affect patient outcomes…

This study aims to measure lung function in premature infants with bronchopulmonary dysplasia (BPD) using a technique called forced oscillometry. Researchers will compare these measurements with those from healthy full-term infants. The goal is to better understand lung mechanics…

This study observes 325 adults with acute breathing failure who are using non-invasive breathing support like high-flow oxygen or a mask ventilator. Researchers want to find out which patients end up needing a breathing tube. The goal is to better predict and prevent treatment fa…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This study follows 550 children who need ECMO (a machine that does the work of the lungs) after sudden, severe breathing failure. Researchers will track their abilities and quality of life for a year after leaving the ICU. They will also compare two groups: one that received ECMO…

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study will use a special imaging technique called electrical impedance tomography (EIT) to see how lung volume changes in premature babies who are on a type of breathing support called synchronized noninvasive positive pressure ventilation (sNIPPV). Researchers want to under…

This study looks at whether special imaging tests can help predict a serious lung condition called bronchopulmonary dysplasia (BPD) in premature babies. Researchers will use electrical impedance tomography (EIT) and lung ultrasound to check how air moves in the lungs of 104 prete…

This study is for preterm infants who need breathing help. It tests whether a low or high air flow rate changes carbon dioxide levels in their blood. 45 babies will be monitored for three hours at each flow setting. The goal is to find the safest and most effective flow rate for …

This study is looking for better ways to predict if a lung transplant will be rejected. Researchers will collect blood samples from 244 lung transplant recipients over time and analyze them using advanced techniques. The goal is to create a model that can identify early signs of …

This study tracks complications from a lung-opening procedure used in children under 14 with acute respiratory distress syndrome (ARDS) who are on a breathing machine. The procedure, called alveolar opening maneuver with PEEP titration, aims to improve oxygen levels but can cause…

This study involves 60 critically ill patients in the ICU who are on breathing machines (ventilators). Researchers want to see if a new scoring system can automatically detect when a patient is struggling to breathe. The goal is to improve how doctors monitor and care for these p…

This pilot study is testing a new ultrasound tool that measures how much the lungs stretch (strain) in patients on breathing machines in the ICU. The goal is to collect initial data from 10 adults with lung disease to see if this technique can help doctors better monitor and prev…