Could a quick CPAP boost help preterm babies breathe better?

NCT ID NCT07522346

Recruiting now Knowledge-focused Sponsor: Murdoch Childrens Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This study tests whether briefly increasing the air pressure from a CPAP machine before giving surfactant therapy helps preterm babies' lungs work better. Surfactant is a natural substance that helps immature lungs stay open, and it's often given through a thin tube. The trial will compare this 'lung recruitment' approach to standard care in 36 infants born between 24 and 32 weeks. The goal is to see if the simple pressure change improves how evenly air spreads in the lungs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lung recruitment manoeuvre (increased CPAP pressure) before minimally invasive surfactant therapy
What this could lead to: If it works, this could point toward a simple way to make surfactant therapy more effective for preterm babies, potentially reducing the need for more breathing support.
What could go wrong: This is a very small, early study (36 infants) looking at lung patterns, not long-term outcomes. The intervention is brief and may not show clear benefits or could cause temporary discomfort.

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Conditions

The condition(s) this trial relates to.

newborn respiratory distress syndrome Pulmonary Atelectasis respiratory distress syndrome in premature infants

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SURFACTANT DEFICIENCY SYNDROME NEONATAL

Contacts and locations

Locations

Joan Kirner Women's and Children's Hospital
RECRUITING

Saint Albans, Victoria, 3021, Australia

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