Murdoch Childrens Research Institute

This study is testing a personalized approach to dosing a critical anti-rejection drug (tacrolimus) for children who have received a solid organ transplant. Researchers will use a child's genetic information to predict the best starting dose and then use computer modeling to fine…

This trial is testing whether treating children's bone and joint infections with oral antibiotics alone works as well as the standard treatment that starts with intravenous (IV) antibiotics. It involves 285 children aged 1-18 in Australia and New Zealand. The goal is to see if ki…

This study aims to help babies with serious infections like sepsis get the right dose of a key antibiotic (vancomycin) faster. Currently, doctors must wait 1-2 days to check if the dose is correct, delaying optimal treatment. Researchers are testing if checking drug levels after …

This trial is testing two different oral medications for people with abnormal, non-cancerous growths of blood or lymph vessels (vascular malformations). The goal is to see if a year of treatment can reduce patients' most bothersome symptoms and shrink the growths. The specific dr…

This study is testing if using a web app to calculate a custom dose of the antiviral drug ganciclovir works better than the standard fixed dose for children with weakened immune systems who have a CMV virus infection. Researchers will compare how many children in each group clear…

This study is comparing two antibiotic treatments for children with complicated urinary tract infections (UTIs). It will test if a single dose of IV antibiotics followed by pills is as effective as three days of IV antibiotics. The goal is to see if kids can get better just as qu…

This study is checking how well a venom allergy treatment works years after people finish it. Researchers are recruiting 100 Australian adults who completed a 3-6 year treatment program for Jack Jumper ant allergy. Participants will have a supervised ant sting in a hospital to te…

This study is testing whether a new, portable ultrasound device that uses artificial intelligence (AI) can accurately screen infants for developmental dysplasia of the hip (DDH). Researchers will compare the AI scan results to the current standard ultrasound in 240 infants alread…

This study is testing whether a speech-generating app on an iPad can help children with dementia communicate. It involves 38 children, ages 3 to 12, who have very limited speech. Each child will try using the device for 6 weeks and also have a 6-week period without it, so researc…

This is a small, early-stage study to see if a special exercise program can help children with acute lymphoblastic leukemia (ALL) who are showing early signs of muscle weakness and frailty from their treatment. Researchers will enroll 60 children aged 5-17 and randomly assign tho…

This small pilot study is testing whether medicinal cannabis is a practical and acceptable option to help ease symptoms like pain in children receiving palliative care for serious, non-cancer illnesses. It will enroll 10 children and young adults to see if families can follow the…

This study aims to see if data from wearable devices, like smartwatches, can help detect infections earlier in children receiving cancer treatment. Researchers will collect heart rate, activity, and other health data from 150 children over four weeks to train a computer model. Th…

This study is testing a special information tool designed to help young cancer survivors and their parents make informed decisions about preserving fertility after cancer treatment. Researchers want to see if this tool, when added to standard information, helps people feel more k…

This study is testing whether a research method is practical and acceptable for young patients (ages 6-25) newly diagnosed with Hodgkin or Non-Hodgkin lymphoma. It involves giving small 'probe' medications at scheduled hospital visits and taking blood samples to see how the body …

This study aims to understand why national plans to provide medical oxygen often don't work as intended in practice. Researchers will interview government officials, healthcare workers, and other stakeholders in six African and Asian countries over four years. The goal is to iden…

This study is checking in on children and young adults who received a special food allergy treatment 5 to 15 years ago. Researchers want to see if those who achieved remission from their peanut, egg, or milk allergy have better long-term quality of life and fewer reactions than t…

This study is preparing for a future clinical trial about antibiotic use in children. Researchers want to see if it's practical to use Garmin smartwatches to track symptoms like heart rate and sleep in kids (ages 4-17) being treated for common infections. They will also ask famil…

This study is testing whether a simple mental health screening and support program can work for parents and caregivers of children with chronic illnesses. One hundred caregivers will complete a mental health questionnaire during their child's hospital appointment and receive info…