Murdoch Childrens Research Institute

This study looks at a new method for removing breathing tubes from very premature babies (born before 32 weeks). Normally, doctors remove the tube first and then put on a gentle breathing mask. The new method puts the mask on first, before removing the tube. Researchers want to s…

This phase 2 trial is testing two targeted drugs—alpelisib and mirdametinib—in 50 people with slow-flow or fast-flow vascular malformations that haven't responded to standard treatments. The goal is to see if these drugs can improve each person's most bothersome symptom over 48 w…

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This study tests whether a web app that customizes the dose of the antiviral drug ganciclovir can clear cytomegalovirus (CMV) faster in 232 children with weakened immune systems. Participants are recruited from seven hospitals in Australia and New Zealand. The goal is to see if p…

This study tests whether using a child's genetic information to guide the dose of the anti-rejection drug tacrolimus can help achieve safer and more effective drug levels after a solid organ transplant. About 45 children aged 1-18 who receive a kidney, liver, or heart transplant …

This study compares a single dose of IV antibiotics followed by two days of oral antibiotics against the standard three days of IV antibiotics for children with complicated urinary tract infections (UTIs). The goal is to see if the shorter IV course is just as effective at resolv…

This study looks at whether giving children with bone and joint infections antibiotics only by mouth works just as well as starting with IV antibiotics for a few days and then switching to pills. About 285 children aged 1 to 18 from hospitals in Australia and New Zealand will tak…

This study tests whether an artificial intelligence (AI) system can help doctors accurately screen babies for developmental dysplasia of the hip (DDH) using a small, handheld ultrasound device. About 240 babies already scheduled for a standard hip ultrasound will also receive an …

This study tests a group therapy program called TAG TEAM for trans and gender diverse teens aged 12-17. The program helps them understand and cope with stress from discrimination and rejection. Researchers will compare the program to a waitlist to see if it reduces anxiety, depre…

This trial tests whether an iPad loaded with a speech-generating app can help children aged 3-12 with rare genetic conditions who have very limited speech. Each of the 38 participants will use the device during therapy sessions and also receive usual care, in a crossover design. …

This study looks at whether giving parents of children with chronic conditions a mental health questionnaire during clinic visits is practical and helpful. About 100 parents will fill out the survey and receive a list of support services. Researchers will follow up at 3 and 6 mon…

This pilot study tests whether a physical activity program can help children aged 5–17 with acute lymphoblastic leukemia maintain muscle strength and avoid frailty during early treatment. Kids who show signs of weakness after five weeks of chemotherapy are randomly assigned to ei…

This pilot study will test whether medicinal cannabis can help ease symptoms like pain, muscle spasms, and gut problems in 10 children (ages 6 months to 21 years) who are receiving palliative care for non-cancer conditions. The study focuses on whether the approach is practical a…

This study looks at how well venom immunotherapy protects people with Jack Jumper ant allergy years after treatment stops. About 100 adults who completed 3-6 years of therapy and have been off treatment for at least 18 months will have a supervised sting challenge and blood test.…

This study looks at how medical oxygen programs work in six countries across Africa and Asia. Researchers will interview policymakers, health workers, and others to find out what helps or hinders oxygen access. The goal is to improve national and global policies, not to test a ne…

This study looks at children and young people who completed an 18-month oral immunotherapy (OIT) treatment for peanut, egg, or milk allergy 5 to 15 years ago. Researchers want to compare quality of life between those whose allergies went into remission and those whose did not. Pa…

This study tests a fertility preservation decision aid for young cancer survivors and their parents. The goal is to see if the tool helps them better understand fertility status and future parenthood options. About 358 participants will be randomly assigned to receive either the …

This study is testing whether wearable devices (like smartwatches) can help catch infections early in children receiving cancer treatment. About 150 kids aged 5-18 will wear a device for 4 weeks to track heart rate, activity, and other health signs. The goal is to build a compute…

This study looks at how families feel about antibiotic use and whether a Garmin smartwatch can track symptoms in children aged 4-17 with common infections like UTIs, tonsillitis, or skin infections. About 300 children from the Royal Children's Hospital Emergency Department will w…

This study looks at how young people (ages 6-25) with Hodgkin or non-Hodgkin lymphoma process certain medications. Researchers will give tiny, non-therapeutic doses of two common drugs (omeprazole and dextromethorphan) and measure how they are broken down in the body. The goal is…