Murdoch Childrens Research Institute

This study tested whether a smaller dose of the Pfizer COVID-19 booster vaccine works as well as the full dose. It involved 601 healthy adults in Mongolia who had previously received two doses of either Sinopharm, AstraZeneca, or Sputnik V vaccines. Researchers compared the immun…

This study tested whether a steroid nasal spray could help children with snoring and sleep-disordered breathing. It involved 130 children aged 3-12 who did not improve after first trying a simple saltwater spray. The main goal was to see if the medicated spray could reduce sympto…

This study aimed to find out if it's as safe to stop antibiotics early for children with cancer who develop a serious fever complication called febrile neutropenia. Researchers compared stopping antibiotics before blood counts fully recovered (early stopping) to the standard prac…

This study tested if a treatment called oral immunotherapy could help toddlers with nut allergies. Children aged 18-36 months who were allergic to two types of nuts were either given tiny, controlled daily doses of nut flour or told to strictly avoid nuts for 18 months. The goal …

This large study tested whether giving a single dose of the antibiotic azithromycin to mothers during labor could prevent skin and other infections in their babies during the first year of life. Over 2,100 mother-baby pairs in Fiji participated, with half receiving the antibiotic…

This study tested if introducing tree nuts early to infants who are already allergic to peanuts can prevent them from developing additional nut allergies. It compared a supervised hospital introduction of four nuts followed by home introduction of others against the standard care…

This small, completed study tested whether methylphenidate, a medication often used for ADHD, could improve speech clarity in children aged 6-12 with childhood apraxia of speech. Eighteen children participated in an 8-week trial where they took either the medication or a placebo …

This study tested whether a purified form of CBD (cannabidiol) oil could help reduce severe behavioral problems like aggression and irritability in children and teenagers with intellectual disability. Over 130 participants aged 6 to 18 were randomly given either CBD or a placebo …

This study aimed to safely learn more about how a common strain of strep throat bacteria causes infection. Researchers carefully exposed 40 healthy adult volunteers to the bacteria in a controlled setting to see how much is needed to cause illness and how the body responds. The i…