Murdoch Childrens Research Institute

This study looked at whether a smaller (fractional) dose of the Pfizer COVID-19 booster works as well as the full dose. It involved 601 healthy adults in Mongolia who had already received two doses of Sinopharm, AstraZeneca, or Sputnik vaccines 6 to 9 months earlier. The goal was…

This study looked at whether a home-based, dietitian-guided egg ladder is safe and practical for infants newly diagnosed with egg allergy. Over 100 babies followed a step-by-step plan to eat egg in increasing amounts, from baked to raw, over 12 months. The goal was to help them t…

This study looked at whether stopping antibiotics early is as safe as waiting for the child's white blood cell count to recover in children with cancer who have a fever and low white blood cells. 55 children took part. The goal was to see if early stopping leads to more problems …

This study tested a low-dose oral immunotherapy (OIT) treatment for young children aged 18-36 months with allergies to two nuts. Over 18 months, one group received daily tiny doses of the nuts they were allergic to, while the other group avoided them completely. The goal was to s…

This study tested whether giving mothers a single 2-gram dose of azithromycin during labour (or just before a C-section) could prevent skin and soft tissue infections in their babies by 3 months of age. Over 2,100 pregnant women participated. The goal was to see if this simple, o…

This study tested whether giving tree nuts (like almonds and cashews) early to babies with peanut allergy could prevent them from developing tree nut allergies. About 212 infants aged 4-11 months with peanut allergy were randomly assigned to either a supervised hospital feeding o…

This study tested whether a purified form of cannabidiol (CBD) can reduce severe behavioral problems in children aged 6 to 18 with intellectual disability. Over 8 weeks, 132 participants received either CBD or a placebo. The goal was to see if CBD could ease symptoms like irritab…

This study tested a nasal steroid spray in 130 children aged 3-12 who snore and have sleep-disordered breathing. The goal was to see if the spray could ease symptoms enough to avoid the need for tonsil or adenoid surgery. Results were measured using a parent questionnaire at 6 an…

This study tested whether methylphenidate, a medication often used for ADHD, could improve speech clarity in children aged 6 to 12 with childhood apraxia of speech. In a double-blind, placebo-controlled crossover design, 18 children took the drug or a placebo for 4 weeks each. Th…

This study tested a new way to safely give healthy volunteers a specific type of Strep A bacteria (called M1) to cause a sore throat. The goal was to see if the procedure is safe and to learn how the body reacts to the infection. Forty healthy adults aged 18 to 40 took part. The …