Murdoch Childrens Research Institute

This trial tests multiple new treatments to improve outcomes for children receiving a stem cell transplant. It includes children from 1 week to 18 years old who are getting a transplant. The goal is to reduce serious complications like organ failure and infections, and make trans…

This phase III trial tests whether giving tranexamic acid continuously for 24 hours after hip surgery can reduce blood loss in non-ambulatory children with cerebral palsy. About 52 children aged 4 to 16 will be randomly assigned to receive either the drug or a placebo. The goal i…

This study tests whether children with bacterial infections like urinary tract infections, cellulitis, or pneumonia can safely stop oral antibiotics once their symptoms go away, instead of finishing the entire course. About 200 children aged 1 to 17 who have already received IV a…

This trial studies whether a slower inflation setting (long pressure rise time) on mechanical ventilators can improve oxygen levels in extremely preterm infants compared to the standard faster setting. About 68 babies born before 28 weeks will be randomly assigned to both setting…

This study will compare live music therapy to recorded music in 10 children aged 1-18 with disorders of consciousness after severe brain injury. Over 10 days, researchers will measure changes in consciousness using a simple checklist and video recordings. Parents will also share …

This study tests whether briefly increasing the air pressure from a CPAP machine before giving surfactant therapy helps preterm babies' lungs work better. Surfactant is a natural substance that helps immature lungs stay open, and it's often given through a thin tube. The trial wi…