Murdoch Childrens Research Institute

This trial tests multiple new treatments to improve outcomes for children receiving a stem cell transplant. It includes children from 1 week to 18 years old who are getting a transplant. The goal is to reduce serious complications like organ failure and infections, and make trans…

This phase III trial tests whether giving tranexamic acid continuously for 24 hours after hip surgery can reduce blood loss in non-ambulatory children with cerebral palsy. About 52 children aged 4 to 16 will be randomly assigned to receive either the drug or a placebo. The goal i…

This trial tests whether a telehealth program called Babble Boot Camp can improve early communication in babies born very preterm (before 32 weeks). Parents in the treatment group join weekly 15-minute coaching sessions with a speech pathologist for six months, learning activitie…

This trial studies whether a slower inflation setting (long pressure rise time) on mechanical ventilators can improve oxygen levels in extremely preterm infants compared to the standard faster setting. About 68 babies born before 28 weeks will be randomly assigned to both setting…

This study will compare live music therapy to recorded music in 10 children aged 1-18 with disorders of consciousness after severe brain injury. Over 10 days, researchers will measure changes in consciousness using a simple checklist and video recordings. Parents will also share …