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Slower lung inflation may protect preterm Babies' lungs

NCT ID NCT07101419

Not yet recruiting Symptom relief Sponsor: Murdoch Childrens Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial studies whether a slower inflation setting (long pressure rise time) on mechanical ventilators can improve oxygen levels in extremely preterm infants compared to the standard faster setting. About 68 babies born before 28 weeks will be randomly assigned to both settings in a crossover design. The goal is to find a gentler way to support breathing and reduce lung damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
mechanical ventilator setting (pressure rise time)
What this could lead to
If it works, this could lead to a gentler ventilator setting that reduces lung damage in extremely preterm babies.
What could go wrong
This is a small, early-stage crossover trial with only 68 infants, so results may not apply broadly. The intervention is a temporary setting change, not a cure or long-term treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

newborn respiratory distress syndrome respiratory distress syndrome in premature infants Respiratory Distress Syndrome, Newborn

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESPIRATORY DISTRESS SYNDROME IN PREMATURE INFANT RESPIRATORY DISTRESS SYNDROME, NEWBORN

Contacts and locations

Locations

  • Joan Kirner Women's and Children's Hospital

    Saint Albans, Victoria, 3021, Australia

  • Mercy Hospital for Women

    Heidelberg, Victoria, Australia

  • The Royal Women's Hospital

    Parkville, Victoria, 3051, Australia

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