New study tests safer sedation for tiny lungs
NCT ID NCT04016246
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether giving a sedative called propofol to very premature babies (under 32 weeks) before a less invasive breathing treatment (LISA) is safe and reduces the need for a breathing machine. The trial involved 233 infants with breathing problems. Researchers compared propofol to a placebo, with rescue pain medicine available if needed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
propofol
What this could lead to
If it works, this could provide a safer way to give sedation to premature babies during a breathing treatment, potentially reducing the need for a breathing tube.
What could go wrong
This is a completed Phase 3 trial, but results may not apply to all premature infants. Propofol can cause side effects like low blood pressure or breathing problems in newborns.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ap-H Marseille
Marseille, 13000, France
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CHU Grenoble Alpes
Grenoble, Isère, 38043, France
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Ch Rennes
Rennes, 35000, France
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Chi Creteil
Créteil, 94000, France
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Chi Poissy St Germain
Poissy, 78300, France
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Chu Amiens
Amiens, 80000, France
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Chu Angers
Angers, 49000, France
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Chu Brest
Brest, 29200, France
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Chu Chambery
Chambéry, 73000, France
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Chu Limoges
Limoges, 87000, France
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Chu Nantes
Nantes, 44000, France
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Chu Nimes
Nîmes, 30000, France
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centre hospitalier deTroyes
Troyes, Aube, 10000, France