University Hospital, Grenoble

This study looks at the best way to give anesthesia to brain-dead organ donors during surgery to remove organs. The goal is to keep their blood pressure steady, which helps protect the organs for transplant. About 270 donors will be randomly assigned to receive one of three optio…

This study tests whether a small, single-use home monitor called Sunrise can help doctors decide how to adjust CPAP therapy for people with obstructive sleep apnea who are not getting enough benefit. About 105 adults will use the Sunrise device at home and also undergo a standard…

This study explores whether a simple test of naming and identifying famous landmarks can tell apart healthy older adults from those with Alzheimer's disease. Researchers will compare the performance of 220 participants (half with Alzheimer's, half without) on this monument-based …

This study is testing a new, non-invasive way to detect Alzheimer's disease by looking for specific proteins (amyloid and tau) in stool samples. The goal is to see if these proteins can serve as early warning signs, potentially allowing for earlier diagnosis and treatment. Resear…

This pilot study is testing whether specially trained nurses can safely diagnose non-traumatic chest pain in the emergency department using a step-by-step guide based on medical recommendations. About 182 adults with chest pain will be split into two groups: one managed by nurses…

This study tests if a procedure called arterial embolization using Lipiodol is safe for people with painful hand osteoarthritis that hasn't improved with standard treatments. Fifteen participants will receive the procedure and be followed for 6 months to track side effects, pain …

This study looks at two different exercise programs on a stationary bike for frail adults aged 70 and older. One program uses short bursts of hard pedaling (HIIT), while the other uses steady, moderate pedaling (MICT). The goal is to see which type of exercise better improves hea…

This early-phase trial tests whether a single low dose of morphine can reduce the chance that COPD patients in respiratory distress will fail non-invasive ventilation (a breathing mask). The study will enroll 24 adults with a COPD flare-up who need a breathing mask. Researchers w…

This study tests if a liquid medicine called midazolam can help elderly patients with moderate to severe memory problems who refuse care. About 30 hospitalized patients will receive the medicine before care to see if it reduces their resistance. The goal is to make necessary care…

This study tests whether giving a specific nerve block (ESP block) within 6 hours of a severe chest injury can reduce the number of days patients need a ventilator. The block numbs the chest wall to ease pain and improve breathing. 400 adults with at least 3 rib fractures will be…

This study looks at how certain changes in the ACTG2 gene affect the development and function of intestinal muscle in children with a rare condition called pediatric intestinal pseudo-obstruction (PIPO). Researchers will take cells from 4 patients with PIPO and grow them into min…

This study looks at 100 kidney transplant patients to understand where the BK virus comes from and why some people get sicker than others. Researchers will compare the virus in patients and their donors, and check how the immune system responds. The goal is to find better ways to…

This study is testing a two-step screening method to find advanced liver fibrosis in people who don't yet have symptoms. First, a routine blood test calculates a score called FIB-4. If that score is high, patients get a more specialized non-invasive test. The goal is to see how w…

This study collects tumor samples from 60 patients with colorectal cancer before they receive any chemotherapy. Researchers will grow mini-tumors (organoids) in the lab to study how the immune system and tumor cells interact. The goal is to understand why 30-50% of patients do no…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel function in the brains of inactive adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers in 64 participants. Th…

This study looks at how serious respiratory infections (like flu, COVID-19, and RSV) affect the ability of adults aged 60 and older to live independently. Researchers will follow 1,600 hospitalized seniors across multiple countries to track changes in daily activities such as bat…

This study surveys up to 900 adults with type 1 diabetes who use a closed-loop insulin system for at least 4 months. The goal is to understand how satisfied they are with the special 'physical activity mode' designed to prevent low blood sugar during exercise. Participants fill o…

This study looks at whether a non-invasive breath measurement (EtCO2) can help doctors quickly tell how serious a COPD attack is. Researchers will monitor 240 adults in the emergency room to see if EtCO2 levels can predict the need for breathing support. If successful, this could…

This study looks at a program where family doctors work with a hospital to find liver scarring (fibrosis) early in people at risk. About 150 adults with a high FIB-4 score will get a special liver scan (Fibroscan). The goal is to see if those with scarring get the right follow-up…

This study looks at whether a special type of scan (LuPSMA-SPECT/CT) can tell doctors early if a targeted radiation therapy is working in men with advanced prostate cancer that no longer responds to hormone therapy. About 130 participants will be followed to see if changes on the…

This study aims to develop new antibody treatments for Pseudomonas aeruginosa, a bacteria that can be resistant to many antibiotics. Researchers will collect blood from 30 patients who have had this infection to isolate and produce antibodies that can fight the bacteria. The goal…

This registry will follow 100 adults in France who undergo renal denervation (RDN) for high blood pressure. The procedure uses radiofrequency or ultrasound to calm overactive kidney nerves. Researchers will measure blood pressure changes at home and in the clinic over one year to…

This study is a practice run to see how well different brain and heart scans (MEG, MRI, EEG, ECG) work in healthy volunteers, people with Parkinson's disease, and those with paralysis. Researchers want to make sure the equipment and procedures are ready for larger future studies.…

This study tests a new device that uses light to measure pulse waves, which might help estimate blood pressure. Researchers will compare it to a standard device in 27 healthy adults. The goal is to see if this simpler method is reliable.