University Hospital, Grenoble

This study tested whether adding an experimental drug called NP137 to standard chemotherapy (mFOLFIRINOX) is safe and might work better for people with advanced pancreatic cancer that cannot be removed by surgery. The main goal was to check for side effects in about 43 patients. …

This study tested if a pill called bosentan could lower blood pressure as well as the standard CPAP breathing machine in people with sleep apnea and mild high blood pressure. It involved 19 participants who were not taking blood pressure medication. The goal was to see if blockin…

This study looked at whether a supervised weight loss program focusing on nutrition and behavior changes could help people with obesity and sleep apnea. Researchers followed 396 overweight or obese participants, some with sleep apnea and some without, to see if the program helped…

This study tested a new, non-invasive imaging scan to measure blood flow to the heart muscle. Researchers compared this new scan to a standard, but invasive, procedure in 36 patients with coronary artery disease. The goal was to see if the new scan could accurately measure heart …

This study tested three different non-invasive stimulation techniques to see which works best for reducing long-term pain in people with algoneurodystrophy (also called Complex Regional Pain Syndrome). Thirty-six patients who hadn't gotten relief from standard pain medications tr…

This study tested whether using virtual reality (VR) headsets could help reduce anxiety in patients waiting for a heart catheterization procedure. Researchers enrolled 156 patients and randomly assigned some to use VR while waiting, comparing their anxiety levels to patients rece…

This study tested whether a non-invasive brain stimulation technique, called repetitive transcranial magnetic stimulation (rTMS), could improve pain relief when added to standard rehabilitation exercises for people with fibromyalgia. Forty-two patients were randomly assigned to r…

This study aimed to understand the long-term health of people with sleep apnea. Researchers followed over 30,000 patients from a European database to track serious health events like heart problems, diabetes, and cancer. They also looked at whether using the standard CPAP breathi…

This study aimed to find signs that could help doctors predict and diagnose sleep apnea earlier in people with Down syndrome. Researchers studied 40 adults with Down syndrome, looking at factors like facial structure, physical activity levels, and heart function during sleep. The…

This study tested a new questionnaire designed to measure the mental and mood changes that happen in people with Parkinson's disease as their medication levels change. Researchers enrolled 130 French-speaking Parkinson's patients to see if the questionnaire is reliable and useful…

This study aimed to understand how two specific muscle movement disorders—cervical dystonia (involuntary neck twisting) and blepharospasm (uncontrolled eyelid closure)—affect a person's walking. Researchers measured the walking patterns of 40 people with these conditions, both be…

This study tested new sticker-like sensors that measure carbon dioxide and oxygen levels through the skin without needles. Researchers compared these new optical sensors to standard hospital equipment to see if they work accurately. The study involved 20 healthy adults to validat…

This study aimed to understand how the brain responds to exercise when oxygen levels are low, like at high altitudes. Researchers tested 30 healthy men using brain scans and other tools while they exercised in normal and low-oxygen air. The goal was to learn if the brain itself c…

This study aimed to find out how common obstructive sleep apnea is in adults with type 1 diabetes who use insulin pumps. Researchers enrolled 825 participants to measure sleep apnea and see if it is connected to diabetes-related health problems like heart, kidney, or nerve issues…

This study aimed to understand how ultra-distance mountain running affects the body. Researchers measured muscle fatigue, recovery, and other physical changes in experienced trail runners before and after races ranging from 40 to 160 kilometers. The goal was to gather detailed in…

This study aimed to understand why patients with chronic inflammatory arthritis often don't follow through with recommended care for their other health conditions. Researchers surveyed 229 patients and their doctors to identify what gets in the way of following treatment advice. …

This study tested a new decision-making guide (a 'decision tree') to help surgeons choose the best treatment for complex fractures of the hip socket (acetabulum). Researchers followed 250 adult patients at a major French trauma center to see if using this guide led to better pati…

This study used brain scans (fMRI) to understand how normal aging changes the way people process emotional images. Researchers compared two groups—younger adults (20-35) and older adults (60-85)—while they viewed emotional scenes and made judgments about their feelings or potenti…

This study aimed to understand how the COVID-19 lockdowns affected people's health behaviors. Researchers tracked nearly 5,000 adults in France who were already part of a weight-loss program. They measured changes in weight, sleep, stress, and activity levels before, during, and …

This study aimed to understand if taking certain dietary supplements (like L-arginine or nitrate) before exercise could improve performance or how the body responds to physical activity. Researchers tested healthy but sedentary young and older adults. They measured things like mu…

This study explored how people's internal thoughts and self-talk affect how difficult trail running feels. Researchers worked with 76 trail runners to see if training their mental approach could change their perception of effort during exercise. The goal was to understand the con…

This study used brain scans (fMRI) to better understand how a key memory area of the brain, the hippocampus, works. Researchers tested 60 healthy young adults while they performed memory and visual tasks in a scanner. The goal was to learn if this brain region is specialized for …