New pain block could help chest trauma patients breathe on their own sooner

NCT ID NCT05920109

Recruiting now Symptom relief Sponsor: University Hospital, Grenoble Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving a specific nerve block (ESP block) within 6 hours of a severe chest injury can reduce the number of days patients need a ventilator. The block numbs the chest wall to ease pain and improve breathing. 400 adults with at least 3 rib fractures will be randomly assigned to get the block plus standard care, or standard care alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ropivacaine
What this could lead to: If it works, this could reduce the number of days patients with severe chest injuries need a breathing machine, potentially speeding recovery.
What could go wrong: This is an early-stage trial with no prior large-scale evidence. The nerve block may not work as expected, and there are risks like catheter failure or rare complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

agnosia Thoracic Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEVERE CHEST TRAUMA

Contacts and locations

Locations

CH Annecy Genevois
RECRUITING

Épagny, 74370, France
CHRU Hôpitaux De Tours
RECRUITING

Tours, 37000, France
CHU Bordeaux - Pellegrin
RECRUITING

Bordeaux, 33000, France
CHU Clermont-Ferrand
RECRUITING

Clermont-Ferrand, 63000, France
CHU Grenoble Alpes
RECRUITING

Grenoble, 38049, France
CHU de Lille
RECRUITING

Lille, 59000, France
Chu Toulouse - Hopital Purpan
RECRUITING

Toulouse, 69003, France
Chu Toulouse - Hopital Rangueil
RECRUITING

Toulouse, 31059, France
Hopital Beaujon - AP-HP
RECRUITING

Clichy, 92118, France
Hôpital Européen Georges Pompidou - AH-HP
RECRUITING

Paris, 75015, France
Hôpital Lyon Sud
RECRUITING

Pierre-Bénite, 69310, France
Hôpital Pitie Salpetriere - AP-HP
RECRUITING

Paris, 75013, France
Hôpital d'Instruction des Armées Sainte Anne
RECRUITING

Toulon, 83000, France
Hôpital d'instruction des armées Percy
RECRUITING

Clamart, 92140, France