Gentler breathing support may help preterm babies avoid breathing tubes

NCT ID NCT07693530

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial compares two noninvasive breathing support methods—heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP)—in premature infants (born at 28-34 weeks) with moderate respiratory distress syndrome. The goal is to see which method better prevents the need for a breathing tube and mechanical ventilation in the first week of life. The study also tracks side effects like nasal injury and infections.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP)
What this could lead to
If one method works better, it could reduce the need for invasive breathing tubes in premature babies, lowering risks of injury and infection.
What could go wrong
This is a small, single-center trial, so results may not apply to all hospitals. Both methods are already used, so the difference may be small.

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Conditions

The condition(s) this trial relates to.

newborn respiratory distress syndrome Premature Birth Respiratory Distress Syndrome, Newborn

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Kayseri City Hospital

    Kayseri, Kayseri, 38090, Turkey (Türkiye)

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