Murdoch Childrens Research Institute

This study tests a new approach for removing breathing tubes in very premature babies (born before 32 weeks). Instead of taking the tube out first and then starting gentle breathing support, doctors will start the support before removing the tube. The goal is to see if this keeps…

This study compares two antibiotic treatments for children with bone and joint infections. One group gets antibiotics only by mouth, while the other starts with IV antibiotics for a few days then switches to oral. The goal is to see if the all-oral approach works just as well for…

This study tests whether using a child's genetic information can help doctors find the best dose of tacrolimus, a drug that prevents organ rejection, more quickly and safely. About 45 children aged 1-18 who receive a kidney, liver, or heart transplant will take part. The goal is …

This study tests whether checking vancomycin levels after the very first dose and adjusting quickly can help infants with sepsis reach the right drug levels faster. About 40 infants under 90 days old will take part. The goal is to avoid dangerous delays in treating serious infect…

This study tests two targeted drugs for people with abnormal blood vessels (vascular malformations). One drug, alpelisib, is for slow-flow types; the other, mirdametinib, is for fast-flow types. About 50 participants aged 2 and older will take the drug for 48 weeks to see if thei…

This study tests whether a web app that customizes the dose of the antiviral drug ganciclovir can clear cytomegalovirus (CMV) better than standard dosing in 232 children with weakened immune systems. Participants are recruited from seven children's hospitals in Australia and New …

This study checks if an artificial intelligence (AI) system can make ultrasound scans more accurate for finding hip dysplasia in babies. About 240 infants will get an extra AI-powered ultrasound during their regular checkup. Researchers will compare the AI results to standard ult…

This study tests whether a special iPad app that generates speech can help children with childhood dementia communicate better. The trial will include 38 children aged 3 to 12. Each child will use the app for a period and also have a period without it, so the team can compare how…

This study compares two treatment plans for children with complicated urinary tract infections (UTIs). One group gets a single IV antibiotic dose followed by two days of oral antibiotics, while the other gets three daily IV doses. The goal is to see if the shorter IV course works…

This small study tests whether a physical activity program can help children (ages 5-17) with acute lymphoblastic leukemia maintain or regain muscle strength during early treatment. Kids who show signs of weakness after 5 weeks of treatment are randomly assigned to either the exe…

This small pilot study will test whether medicinal cannabis can help ease symptoms like pain, muscle spasms, and gut problems in children receiving palliative care for non-cancer conditions. Ten children aged 6 months to 21 years will be randomly given one of two cannabis product…

This study looks at people who finished venom immunotherapy for Jack Jumper ant allergy 1.5 to 5 years ago. Participants will get a supervised sting and blood test to see if they are still protected. The goal is to learn how long the treatment works and how it affects quality of …

This study looks at how families feel about the length of antibiotic treatment for common childhood infections like urinary tract infections, strep throat, and ear infections. It also tests whether children aged 4-17 can comfortably wear a Garmin smartwatch to track symptoms like…

This study tests a fertility preservation decision aid for young cancer survivors (ages 16+) and their parents. The goal is to see if the aid reduces unmet information needs about fertility status, parenthood goals, and storage fees. About 358 participants will be randomly assign…

This study looks at how medical oxygen is provided in six countries in Africa and Asia. Researchers will interview policymakers, healthcare workers, and others to understand challenges and find solutions. The goal is to improve oxygen access for patients with conditions like pneu…

This study looks at children and young people who completed an 18-month oral immunotherapy (OIT) treatment for peanut, egg, or milk allergy 5 to 15 years ago. Researchers want to see if those who achieved remission have a better quality of life compared to those who did not. Part…

This study is testing whether wearable devices like smartwatches can help detect infections early in children receiving cancer treatment. About 150 kids aged 5-18 will wear a device that tracks heart rate, activity, and other health signs for 4 weeks. Researchers will use this da…

This study looks at how the bodies of children and young adults (ages 6-25) with Hodgkin or non-Hodgkin lymphoma process certain drugs. Researchers will give small doses of probe medications during regular hospital visits and take blood samples to measure how the drugs are broken…

This study looks at whether giving parents of children with chronic conditions a mental health questionnaire during clinic visits can help identify stress, anxiety, or depression. About 100 parents will fill out the survey, get their results, and receive a list of support service…