New calculator could help sick newborns get the right antibiotic dose faster

NCT ID NCT05770622

Recruiting now Disease control Sponsor: Murdoch Childrens Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. The study will enroll 40 infants and use a web-based calculator to adjust doses after the first dose if needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: vancomycin
What this could lead to: If successful, this approach could help doctors get the right dose of vancomycin to sick infants faster, potentially improving infection treatment.
What could go wrong: This is a small, early-phase study (40 infants) focused on dosing accuracy, not on curing sepsis. It may not lead to better health outcomes or apply to all infants.

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Conditions

The condition(s) this trial relates to.

bacterial infectious disease with sepsis Infections infectious disease infectious disease with sepsis Sepsis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACTEREMIA INFECTIONS SEPSIS

Contacts and locations

Locations

Monash Newborn
NOT_YET_RECRUITING

Melbourne, Australia
Royal Children's Hospital Melbourne
RECRUITING

Melbourne, Victoria, 3052, Australia
Royal Hospital for Women
NOT_YET_RECRUITING

Sydney, Australia
The Children's Hospital at Westmead
RECRUITING

Sydney, Australia

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