INFECTIONS

This study tests a new vaccine called GNG-DE to see how well it protects against meningococcal disease, a serious infection that can cause meningitis and sepsis. About 240 healthy people aged 3 to 55 will receive either the new vaccine or a reference vaccine. Researchers will mea…

This study tests a special bandage that uses a tiny electric current to fight infection and help wounds heal. About 150 adults in Ukraine with infected traumatic wounds will either get standard care or standard care plus the PowerHeal bandage. Researchers will measure how much th…

This study tests whether taking antibiotic pills for 6 weeks works as well as getting IV antibiotics for infected bone fractures that didn't heal properly. About 250 adults with this condition will be randomly assigned to either oral or IV antibiotics, along with surgery. The goa…

This study tests whether giving L-Citrulline syrup for 28 days can reduce serious complications (like death, organ failure, or readmission) in children aged 1 month to 5 years who are hospitalized with fever and identified as high-risk by a rapid blood test. About 888 children in…

This study tests whether checking vancomycin levels after the very first dose and adjusting quickly can help infants with sepsis reach the right drug levels faster. About 40 infants under 90 days old will take part. The goal is to avoid dangerous delays in treating serious infect…

This study tests an experimental drug called rhu-pGSN added to standard care for people with moderate-to-severe acute respiratory distress syndrome (ARDS) caused by pneumonia or other infections. ARDS is a life-threatening lung condition where fluid builds up in the air sacs, mak…

This study is testing whether Mozobil, a drug already used for bone marrow transplants, can safely improve white blood cell counts in adults with WHIMS syndrome. WHIMS is a rare genetic disorder that causes severe infections, warts, and low white blood cells. Researchers will giv…

This study tests whether giving a single 2-gram dose of azithromycin to pregnant women before starting labor induction can lower the chance of infection for both mother and baby. Researchers will enroll 400 women in their third trimester who are having labor induced for medical o…

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review records of 350 adults who had this surgery in France between 2017 and 2024. The goal is to find out what causes these infections and how they affect recovery, so doctors …

This study involves 200 adults with heart devices who have a suspected infection. The goal is to see if using a team of specialists can help doctors follow best practices, leading to faster diagnosis and removal of infected devices. The study does not test a new treatment but foc…

This study aims to collect information on how well shoulder replacements work over the long term, following up to 20,000 people for at least 10 years. Participants have various shoulder problems like arthritis, rotator cuff tears, or fractures. The goal is to better understand th…

This study tests whether an augmented reality (AR) system can help doctors guide needles during MRI scans. About 25 people aged 3 to 21 who need a needle procedure will try the AR system. The goal is to see if it is safe and works well, not to treat a disease.

This study collects blood samples from 20,000 adults with infections, heart disease, blood clots, or kidney disease. Researchers use the samples to develop and fine-tune new diagnostic tests that can give results quickly at the point of care. No treatment or experimental therapy …

This study aims to find out how common certain infections are among asylum seekers living in reception centers in Italy. Researchers will test 250 adults who have been in Italy for 2 to 36 months for diseases like tuberculosis, HIV, hepatitis, and parasitic infections. The goal i…

This study looks at a rare but dangerous infection caused by Bacillus cereus bacteria in premature newborns. Researchers will analyze the bacteria's genes and patient records from 40 babies to identify which strains are most deadly and what factors increase the risk of death. The…

This study aims to reduce maternal sepsis, a leading cause of death in new mothers, by creating and testing a safety checklist for hospitals. Researchers will track infection rates in over 33,000 birthing people before and after the checklist is put in place. The goal is to see i…

This study is creating a personalized immune score to predict severe infections in 150 transplant patients. By measuring immune cells and virus-specific responses before or one month after transplant, researchers aim to identify those at highest risk. The goal is to tailor monito…

This study will collect information from HeartMate 3 heart pumps in 150 adults to see if pump data can predict problems like bleeding, infection, or frailty. Researchers want to understand how pump readings relate to patients' quality of life and health outcomes. The goal is to h…

This study looks at whether people with cystic fibrosis can collect sputum (mucus) samples at home and mail them in to check for lung infections, instead of coming to the clinic. About 150 adults will provide both home and clinic samples so researchers can compare how well each m…

This early-stage study is testing how much of the antibiotic combination meropenem-pralubactam gets into the lungs of 16 healthy adults in China. Participants will receive four doses of the drug, and researchers will measure its levels in blood and lung fluids. The goal is to und…

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes severe skin and lung infections. Researchers will follow up to 600 patients and their relatives over time, using exams and genetic tests to understand the disease better. No new treatments …

This study compares a new infection management approach to usual care in nursing homes for people with dementia. The goal is to see if the new method reduces antibiotic use and unnecessary hospital visits. About 750 residents aged 60 and older with dementia will take part.

This study tests whether an attachment-based parenting program (ABC) can improve health outcomes like common illnesses, sleep, and weight in low-income Latino children. 260 mothers and their 9-month-old babies will be randomly assigned to either the ABC program or a home reading …

This study is looking for new ways to quickly diagnose sepsis, a life-threatening reaction to infection, in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve early …